Checkpoint inhibition and beyond: Precision immune engineering for the immune-privileged landscape of ocular malignancies [0.03%]
免疫检查点抑制剂之外：眼科恶性肿瘤免疫特许区的精准免疫工程学
Qamar Abuhassan,Kamel Saleh,S Renuka Jyothi et al.
Qamar Abuhassan et al.
Ocular malignancies, particularly uveal and conjunctival melanoma, exemplify tumors that evolve within one of the body's most immunologically constrained ecosystems, the eye's immune-privileged microenvironment. The limited success of PD-1/...
Enhanced anticancer efficacy of α-lipoic acid-loaded TPGS micelles: Synthesis, characterization, and evaluation in a 4T1 breast cancer model [0.03%]
α-硫辛酸负载TPGS微球的制备、表征及其在4T1乳腺癌模型中的抗肿瘤作用研究
Aqeel Akab Sarhan,Ismaeil Haririan,Mohammad Akrami et al.
Aqeel Akab Sarhan et al.
Introduction: α-Lipoic acid (ALA) is a potent antioxidant with anticancer properties, but its clinical application is limited by poor water solubility and low bioavailability. Current nanocarrier systems for ALA delivery...
Enhancing cisplatin chemosensitivity in gastric cancer through LINC00162 silencing: Modulation of the PI3K/AKT pathway and NANOG downregulation [0.03%]
胃癌化疗增敏的LINC00162沉默：PI3K / AKT通路及NANOG下调调节作用
Seyed Ali Hosseini,Amir Ali Mokhtarzadeh,Saeid Ghorbian et al.
Seyed Ali Hosseini et al.
Introduction: Chemotherapy drugs serve as one of the primary treatments for gastric cancer. However, challenges, including drug resistance and adverse side effects of the chemotherapy drugs like cisplatin, limit their eff...
Emerging advancements and expanding technological scope of education and practices in pharmacy and pharmaceutical sciences [0.03%]
药学与药物科学教育及实践的新进展和日益扩大的技术范畴
Jaleh Barar,Karen Fiano,Matthew Seamon et al.
Jaleh Barar et al.
Introduction: The pharmacy profession stands at a pivotal moment, as emerging scientific advancements and evolving healthcare demands require adept pharmacy practitioners and scientists. The integration of precision medic...
Long non-coding RNA PURPL in cancer and cellular regulation: Mechanistic insights and therapeutic potential [0.03%]
长非编码RNA PURPL在癌症和细胞调控中的作用机制及治疗潜力
Nazila Valatabar,Reza Safaralizadeh,Amir Ali Mokhtarzadeh et al.
Nazila Valatabar et al.
Long non-coding RNAs (lncRNAs) constitute a large fraction of the mammalian transcriptome and are increasingly recognized as critical regulators of gene expression and cellular homeostasis. Dysregulation of lncRNAs has been strongly implica...
Integrin-linked kinase (ILK) in hematologic malignancies: Bridging molecular mechanisms to therapeutic innovation [0.03%]
整合素连接激酶(ILK)在血液系统恶性肿瘤中的作用：从分子机制到治疗创新
Omer Qutaiba B Allela,Abdulkareem Shareef,Ashishkumar Kyada et al.
Omer Qutaiba B Allela et al.
Therapy resistance remains a formidable challenge in hematologic malignancies despite significant advances in targeted therapies. This comprehensive review examines integrin-linked kinase (ILK) as a critical molecular hub at the nexus of ce...
Current advancements and future prospects in the biorefinery and hyper-production of astaxanthin from Haematococcus pluvialis [0.03%]
雨生红球藻类胡萝卜素生物炼制及高密度培养的最新研究进展与展望
Jafar Aghajani,Morteza Mirzaei,Ali Choopani et al.
Jafar Aghajani et al.
Astaxanthin (AXT) is a valuable xanthophyll carotenoid extensively utilized across the nutraceutical, pharmaceutical, cosmetic, and aquaculture industries. While this high-demand compound is produced both synthetically and biologically, nat...
Pharmacists in modern primary care and management of diseases: an evidence-based perspective on emerging technologies [0.03%]
基于证据的新兴技术在现代基层医疗和疾病管理中的药剂师作用视角
Jaleh Barar,Yadollah Omidi
Jaleh Barar
Modern healthcare demands warrant the reconceptualization of pharmaceutical practitioners as primary caregivers capable of addressing contemporary medical challenges. Their specialized knowledge in molecular therapeutics, computational medi...
Editorial
BioImpacts : BI. 2026 Apr 22:16:33050. DOI:10.34172/bi.33050 2026
Exosomes: Redefining intercellular communication and the future of translational medicine [0.03%]
外泌体：重新定义细胞间通讯和转化医学的未来方向
Khosro Adibkia,Adel Mahmoudi Gharehbaba
Khosro Adibkia
Exosomes are promising extracellular vesicles for diagnostics, drug delivery, and regenerative medicine. While we have made significant strides in understanding exosomes biogenesis and cargo variability, the translation of exosome-based met...
Editorial
BioImpacts : BI. 2026 Jan 5:16:33099. DOI:10.34172/bi.33099 2026
Synergistic effects of phytochemical cocktail and aerobic exercise on mRNA and lncRNA networks modulating bone turnover in hypothyroid mice [0.03%]
植物化学鸡尾酒和有氧运动对甲状腺功能减退小鼠骨代谢的mRNA和lncRNA网络的协同作用
Malihe Bakhti,Farzaneh Taghian,Khosro Jalali Dehkordi et al.
Malihe Bakhti et al.
Introduction: Metabolic bone disease (MBD) is a multifactorial condition that leads to microarchitectural and bone mass disturbance. The association and mechanisms between MBD and hypothyroidism are not comprehensively el...