Provoking myofibroblast death: Strategies to resolve fibrosis and remodel tumor microenvironment [0.03%]
诱发肌纤维母细胞死亡：解决纤维化和重塑肿瘤微环境的策略
Thangavelu Shalini,Ganapasam Sudhandiran
Thangavelu Shalini
Fibrosis is marked by the excessive accumulation of extracellular matrix (ECM) components, leading to tissue scarring and progressive loss of organ function. Myofibroblasts, which emerge during tissue repair, are specialized contractile cel...
Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade [0.03%]
非小细胞肺癌中炎症细胞因子相关的顺铂耐药性及通过白介素-6受体阻断逆转耐药性
Gizem Calibasi-Kocal
Gizem Calibasi-Kocal
Chemoresistance remains a major challenge in non-small cell lung cancer, especially for cisplatin (DDP)-based therapies, which are a mainstay of treatment. In their study, Dai et al investigate how inflammatory cytokines within the tumor mi...
Expression patterns and clinical implications of chaperonin subunit 3 mRNA and protein in laryngeal squamous cell carcinoma [0.03%]
喉部鳞状细胞癌中伴侣蛋白3mRNA及蛋白表达模式及其临床意义
Bin-Yu Mo,Jia-Ying Wen,Guo-Qiang Chen et al.
Bin-Yu Mo et al.
Background: Laryngeal squamous cell carcinoma (LSCC) is a prevalent head and neck malignancy with suboptimal survival rates due to late detection and therapeutic resistance. ...
Shamshul Ansari,Nada Ahmed
Shamshul Ansari
Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide and ranks among the top five most common malignancies. Helicobacter pylori (H. pylori) infection is recognized as the primary risk factor, although gastric ...
Perioperative immunotherapy combined with standard therapy for human epidermal growth factor receptor 2-positive locally advanced gastric cancer: A case report [0.03%]
HER2阳性局部晚期胃癌围手术期免疫治疗联合标准治疗的病例报告
Xiao-Ting Ma,Guang-Yu Yao,Jian-Li Li et al.
Xiao-Ting Ma et al.
Background: Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) represents a distinct molecular cancer subtype that is often associated with a poor prognosis. While perioperative chemotherapy regi...
Omics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing [0.03%]
整合肿瘤图谱和人工智能利用COSMIC特征和泛癌精确诊断病例以分类白血病细胞恶化期慢性髓系白血病的研究
Abdulkareem AlGarni,Nawaf Alanazi,Sarah AlMukhaylid et al.
Abdulkareem AlGarni et al.
Background: Although chronic-phase chronic myeloid leukemia (CP-CML) is treatable and nearly curable in about 50% of patients, accelerated-phase chronic myeloid leukemia (AP-CML) shows concerning drug resistance, while bl...
ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role [0.03%]
ADAMTS-8和相关激肽释放酶10和5的蛋白酶也具有抑癌作用
Eva G Palacios Serrato,Karen H Medina-Abreu,Enrique Oropeza-Martínez et al.
Eva G Palacios Serrato et al.
Proteases are essential for homeostasis, and their primary function is proteolytic in extracellular and intracellular compartments. The deregulation of expression, abundance, and activity of proteases has been related to several pathologies...
Long-term outcomes of thermal ablation vs surgical resection for single small hepatocellular carcinoma [0.03%]
热消融与手术切除治疗单个早期肝癌的长期疗效分析：倾向评分匹配的生存分析
Ying-Ming Gao,Sai-Kang Tang,Zhi-Wen Luo et al.
Ying-Ming Gao et al.
Background: Thermal ablation (TA), including radiofrequency ablation and microwave ablation, is a commonly used curative treatment for single small hepatocellular carcinoma (sHCC). The relative advantages of TA and surgic...
Ferroptosis, autophagy, and mitochondrial dynamics: Front burners in cancer therapeutics [0.03%]
铁死亡、自噬和线粒体动力学：癌症治疗的热点问题
Minal Garg,Niharika
Minal Garg
This article comments on the article by Rana and Prajapati published in the recent issue. Cancer remains the most formidable public health problem and contributes to significant mortality worldwide. Tumor heterogeneity, toxicity and acquire...
Endoscopic assessment of rectal cancer response after neoadjuvant chemoradiotherapy: A narrative literature review [0.03%]
新辅助放化疗后局部复发直肠癌的内镜评估：叙事性文献回顾
Fotios Seretis,Antonia Panagaki,Paraskevas Gkolfakis et al.
Fotios Seretis et al.
Background: Rectal cancer management is currently evolving with the advent of different neoadjuvant treatment strategies and organ preservation strategies. A significant proportion of patients could achieve complete clini...