ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role [0.03%]
ADAMTS-8和相关激肽释放酶10和5的蛋白酶也具有抑癌作用
Eva G Palacios Serrato,Karen H Medina-Abreu,Enrique Oropeza-Martínez et al.
Eva G Palacios Serrato et al.
Proteases are essential for homeostasis, and their primary function is proteolytic in extracellular and intracellular compartments. The deregulation of expression, abundance, and activity of proteases has been related to several pathologies...
Long-term outcomes of thermal ablation vs surgical resection for single small hepatocellular carcinoma [0.03%]
热消融与手术切除治疗单个早期肝癌的长期疗效分析：倾向评分匹配的生存分析
Ying-Ming Gao,Sai-Kang Tang,Zhi-Wen Luo et al.
Ying-Ming Gao et al.
Background: Thermal ablation (TA), including radiofrequency ablation and microwave ablation, is a commonly used curative treatment for single small hepatocellular carcinoma (sHCC). The relative advantages of TA and surgic...
Ferroptosis, autophagy, and mitochondrial dynamics: Front burners in cancer therapeutics [0.03%]
铁死亡、自噬和线粒体动力学：癌症治疗的热点问题
Minal Garg,Niharika
Minal Garg
This article comments on the article by Rana and Prajapati published in the recent issue. Cancer remains the most formidable public health problem and contributes to significant mortality worldwide. Tumor heterogeneity, toxicity and acquire...
Endoscopic assessment of rectal cancer response after neoadjuvant chemoradiotherapy: A narrative literature review [0.03%]
新辅助放化疗后局部复发直肠癌的内镜评估：叙事性文献回顾
Fotios Seretis,Antonia Panagaki,Paraskevas Gkolfakis et al.
Fotios Seretis et al.
Background: Rectal cancer management is currently evolving with the advent of different neoadjuvant treatment strategies and organ preservation strategies. A significant proportion of patients could achieve complete clini...
Clinicopathological predictors of right para esophageal lymph node metastasis in papillary thyroid carcinoma: A systematic review and meta-analysis [0.03%]
分化型甲状腺癌右侧食管旁淋巴结转移的临床病理预测因子：系统评价和meta分析
Mirza Muhammad Hadeed Khawar,Muhammad Hanan Abid,Muhammad Bilal A Cheema et al.
Mirza Muhammad Hadeed Khawar et al.
Background: Dissection of the right paraesophageal lymph node (RPELN) in managing papillary thyroid carcinoma remains a contentious issue. This meta-analysis assesses previously established and novel risk factors associat...
Tight junction disruption via claudin-6 overexpression promotes invasion and recurrence in high-grade endometrial tumors [0.03%]
Claudin-6过表达介导的紧密连接破坏促进高级别子宫内膜肿瘤侵袭和复发
Noura A A Ebrahim,Tamer S Eissa,Mustafa A Hussein et al.
Noura A A Ebrahim et al.
Background: Claudin-6 (CLDN6), a tight junction protein typically restricted to embryonic tissues, is re-expressed in various cancers. However, its prognostic significance in high-grade endometrial carcinoma (HGEC) remain...
GPR81 nuclear transportation is critical for cancer growth: Interaction of lactate receptor signaling and cell-extracellular matrix mechanotransduction [0.03%]
乳酸受体信号和细胞-胞外基质力学信号转导的相互作用对癌生长至关重要：GPR81核运输是关键因素
Ilya D Klabukov,Elizabeth S Skornyakova,Denis S Baranovskii
Ilya D Klabukov
The interaction between the lactate receptor GPR81 (also known as hydroxycarboxylic acid receptor 1, or HCAR1) and Splicing Factor Proline- and Glutamine-Rich protein promotes the tumor cell malignancy. GPR81 nuclear translocation plays an ...
Single-nucleotide variants in microRNAs associated with breast cancer in women from western Mexico [0.03%]
墨西哥西部妇女乳腺癌相关microRNA单核苷酸变异分析
Marcelo Victorio-De Los Santos,Andrés A Rodríguez-López,Jorge Gutiérrez-Franco et al.
Marcelo Victorio-De Los Santos et al.
Background: MicroRNAs play a key role in regulating gene expression in human cells. Single-nucleotide variants in these molecules have been linked to cancer development, particularly breast cancer (BrC). ...
Role of endoscopic ultrasonography or magnetic resonance imaging for screening of pancreatic cancer in low-risk individuals [0.03%]
内镜超声或磁共振对低风险胰腺癌筛查的作用
Wei-Chen Lin,Lo-Yip Yu,Yang-Che Kuo et al.
Wei-Chen Lin et al.
Background: Magnetic resonance imaging (MRI) and endoscopic ultrasonography (EUS) are recommended in combination for screening pancreatic cancer in high-risk individuals. However, in clinical practice, MRI and EUS are inc...
Gastric organoids: A promising model for studying "inflammation-cancer" transition in atrophic gastritis [0.03%]
胃类器官：研究萎缩性胃炎“炎-癌”转化的前景模型
Chang Liu,Chen-Heng Wu,Yue-Bo Jia et al.
Chang Liu et al.
Current experimental models struggle to simulate the complex process of the transformation from atrophic gastritis to gastric cancer, while gastric organoid technology, especially region-specific modeling, provides a more precise in vitro p...