Development and internal validation of an immune-based prognostic modeling of early-onset colorectal cancer via machine learning [0.03%]
基于免疫的早期结直肠癌预后机器学习模型的开发和内部验证
Xiu Chen,Yong Wang,Heng-Yang Shen et al.
Xiu Chen et al.
Background: Early-onset colorectal cancer (EOCRC) is an aggressive malignancy with rising incidence and poor prognosis in young adults. Circulating immune cells may hold prognostic value, yet their role in EOCRC outcomes ...
Acute exercise-induced catecholaminergic responses after 16 weeks of community-based exercise training in early-stage breast cancer survivors [0.03%]
社区活动训练方案对乳腺癌患者交感神经活性的影响研究
Jeb F Struder,Aiden J Chauntry,Lauren C Bates-Fraser et al.
Jeb F Struder et al.
Background: Breast cancer survivors (BCS) demonstrate attenuated immune cell mobilization following acute exercise, with partial restoration following exercise training. Epinephrine (EPI) and norepinephrine (NE) are respo...
Evaluating murine double minute 2 status as a stratification tool for risk-adapted management in plasma cell neoplasms [0.03%]
评估组蛋白变体H3.3K27M状态作为分层工具以指导对多发性髓系肿瘤的风险适应性管理
Noura A A Ebrahim,Habiba Elfandy,Aya Mohamed Adel Arafat et al.
Noura A A Ebrahim et al.
Background: The E3 ubiquitin ligase murine double minute 2 (MDM2) is a key negative regulator of the tumor suppressor protein p53 and has been implicated in the development of various cancers, including hematologic malign...
Endoscopic submucosal dissection in early esophageal neoplasia: Celebrating efficacy, confronting heterogeneity, and refining surveillance for high-risk patients [0.03%]
内镜下粘膜下剥离术治疗早期食管肿瘤：庆祝其疗效，面对异质性，并为高危患者完善随访监测策略
Shi-Qiong Zhou,Qing-Hua Ke
Shi-Qiong Zhou
Esophageal cancer poses a severe global healthcare burden, with a dismal prognosis primarily due to late-stage diagnosis - only 10%-30% of patients survive 5 years when symptoms trigger medical attention. Endoscopic submucosal dissection (E...
Liquid biopsy in genitourinary cancers: Diagnostic and prognostic implications [0.03%]
液态活检在泌尿生殖系统肿瘤中的诊断及预后价值
Joe Youssef,Amani Yehya,Zahraa Salhab et al.
Joe Youssef et al.
Genitourinary neoplasms, including bladder, prostate, renal, and testicular cancers, represent 25% of all solid tumors worldwide. Great advances have been achieved in the last few decades in diagnostic and therapeutic modalities. Among thes...
Endoscopic submucosal dissection and hybrid endoscopic submucosal dissection for stage 1 rectal neuroendocrine tumors [0.03%]
内镜下粘膜下挖除术与杂交内镜粘膜下挖除术治疗I期直肠神经内分泌肿瘤
Xue-Yan Qiao,Xiu-Jiao Shen,Yan-Hua Lv et al.
Xue-Yan Qiao et al.
Background: The technical complexity and potential for complications associated with endoscopic submucosal dissection (ESD) pose limitations on the widespread use of this procedure for stage 1 rectal neuroendocrine tumors...
Laura S Pernomian,Maria Fernanda Teixeira,Raphael Lc Araujo et al.
Laura S Pernomian et al.
Perioperative fluorouracil, leucovorin, oxaliplatin and docetaxel is currently the standard chemotherapy for resectable gastric and gastroesophageal junction adenocarcinomas, based on the results of FLOT4 and ESOPEC trials. This regimen has...
Radiotherapy for large ruptured hemorrhagic axillary lymph node metastasis from anaplastic lymphoma kinase-positive lung adenocarcinoma: A case report and review of literature [0.03%]
间变性淋巴瘤激酶阳性肺腺癌伴发的大范围破裂出血性腋窝淋巴结转移的放射治疗：1例报告及文献复习
Zhi-Min Li,Yang-Chenxi Wang,Kai-Yue Wang et al.
Zhi-Min Li et al.
Background: Anaplastic lymphoma kinase (ALK) gene fusion is a molecular subtype of non-small cell lung cancer, representing 4%-6% of lung adenocarcinomas. Axillary lymph node (ALN) metastasis from lung cancer is rare, and...
Immune therapy-related hyperprogressive disease: Molecular mechanisms, biomarkers, and clinical strategies [0.03%]
免疫治疗相关性进展加剧疾病：分子机制、生物标志物和临床策略
Xiao-Ming Zhang,Fei-Yu Zhao,Lin-Feng Gao et al.
Xiao-Ming Zhang et al.
Programmed death receptor-1 inhibitors have significantly improved the prognosis of various malignancies. Nevertheless, hyperprogressive disease (HPD), recognized as a severe adverse reaction to immunotherapy, causes a substantial surge in ...
Expanding the role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A multicenter study on uncommon peritoneal malignancies [0.03%]
腹腔不常见恶性肿瘤的细胞减灭术及术后腹腔内化疗多中心研究
Massimo Framarini,Fabrizio D&#x;Acapito,Piero Vincenzo Lippolis et al.
Massimo Framarini et al.
Background: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has become an established treatment for selected patients with peritoneal metastases (PM) from colorectal, ovarian, a...