Relevance and application of sirtuin 3-activated mitophagy in gastric cancer treatment [0.03%]
胃癌治疗中sirtuin 3激活的线粒体自噬的相关性和应用性研究
Hao-Yu Zhao,Chu-Ying Yu,Xin-Tong Ye et al.
Hao-Yu Zhao et al.
Sirtuin 3 (SIRT3) is a primary mitochondrial deacetylase. Studies have confirmed that it directly activates mitophagy by modulating mitochondrial protein acetylation. As a key homeostatic mechanism, mitophagy activation alleviates oxidative...
Impact evaluation of intra-fractional variation on online adaptive radiotherapy for postoperative cervical and endometrial cancer [0.03%]
术中摆位误差对术后宫颈癌和子宫内膜癌在线自适应调强放疗的影响研究
Guang-Yu Wang,Yi-Ning Chen,Yu-Liang Sun et al.
Guang-Yu Wang et al.
Background: Online adaptive radiotherapy (oART) has demonstrated improved target volume coverage and enhanced sparing of surrounding pelvic organs through daily re-optimization based on pretreatment imaging. Recently, ite...
Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in Helicobacter pylori-induced gastric cancer progression [0.03%]
幽门螺旋杆菌诱导的胃癌进展中 Yin Yang 1 基因激活上皮间质转化中的 JAK-STAT3 介导信号通路
Jing-Wan Chen,Jie-Ji Ouyang,Zhen-Hui Wang et al.
Jing-Wan Chen et al.
Background: Helicobacter pylori (H. pylori) infection is widely considered to be a major risk factor for gastric cancer, contributing to its development through the Correa cascade. Yin Yang 1 (YY1) is a transcription fact...
Ultra-processed foods and dietary habits of oncology patients: Risk factor or survival strategy [0.03%]
肿瘤患者的超加工食品及饮食习惯：危险因素还是生存策略？
Balint Madarasz,Mate Adam Balazs,Erzsebet Palfi et al.
Balint Madarasz et al.
The consumption of ultra-processed foods (UPFs) is continuously increasing, and there is growing evidence that these foods contribute to the development and progression of cancer. For oncology patients alone, maintaining nutritional status ...
Provoking myofibroblast death: Strategies to resolve fibrosis and remodel tumor microenvironment [0.03%]
诱发肌纤维母细胞死亡：解决纤维化和重塑肿瘤微环境的策略
Thangavelu Shalini,Ganapasam Sudhandiran
Thangavelu Shalini
Fibrosis is marked by the excessive accumulation of extracellular matrix (ECM) components, leading to tissue scarring and progressive loss of organ function. Myofibroblasts, which emerge during tissue repair, are specialized contractile cel...
Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade [0.03%]
非小细胞肺癌中炎症细胞因子相关的顺铂耐药性及通过白介素-6受体阻断逆转耐药性
Gizem Calibasi-Kocal
Gizem Calibasi-Kocal
Chemoresistance remains a major challenge in non-small cell lung cancer, especially for cisplatin (DDP)-based therapies, which are a mainstay of treatment. In their study, Dai et al investigate how inflammatory cytokines within the tumor mi...
Expression patterns and clinical implications of chaperonin subunit 3 mRNA and protein in laryngeal squamous cell carcinoma [0.03%]
喉部鳞状细胞癌中伴侣蛋白3mRNA及蛋白表达模式及其临床意义
Bin-Yu Mo,Jia-Ying Wen,Guo-Qiang Chen et al.
Bin-Yu Mo et al.
Background: Laryngeal squamous cell carcinoma (LSCC) is a prevalent head and neck malignancy with suboptimal survival rates due to late detection and therapeutic resistance. ...
Shamshul Ansari,Nada Ahmed
Shamshul Ansari
Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide and ranks among the top five most common malignancies. Helicobacter pylori (H. pylori) infection is recognized as the primary risk factor, although gastric ...
Perioperative immunotherapy combined with standard therapy for human epidermal growth factor receptor 2-positive locally advanced gastric cancer: A case report [0.03%]
HER2阳性局部晚期胃癌围手术期免疫治疗联合标准治疗的病例报告
Xiao-Ting Ma,Guang-Yu Yao,Jian-Li Li et al.
Xiao-Ting Ma et al.
Background: Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) represents a distinct molecular cancer subtype that is often associated with a poor prognosis. While perioperative chemotherapy regi...
Omics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing [0.03%]
整合肿瘤图谱和人工智能利用COSMIC特征和泛癌精确诊断病例以分类白血病细胞恶化期慢性髓系白血病的研究
Abdulkareem AlGarni,Nawaf Alanazi,Sarah AlMukhaylid et al.
Abdulkareem AlGarni et al.
Background: Although chronic-phase chronic myeloid leukemia (CP-CML) is treatable and nearly curable in about 50% of patients, accelerated-phase chronic myeloid leukemia (AP-CML) shows concerning drug resistance, while bl...