Single-cell differential abundance detection: A new angle on dissecting tumor heterogeneity [0.03%]
单细胞差异丰度检测：解析肿瘤异质性的新视角
Ying-Xue Xiao,Jing Sun,Ling-Ling Xie et al.
Ying-Xue Xiao et al.
Tumor heterogeneity is one of the central challenges in oncology, contributing to treatment resistance and disease recurrence. Bulk RNA sequencing has advanced understanding of tumor biology, yet its averaging effect conceals cell type-spec...
Pleiotropic regulation of mitochondrial translational factors in governing proliferation, apoptosis and metastasis during cancer progression [0.03%]
癌细胞增殖、凋亡和转移过程中线粒体蛋白合成调控因素的多效性作用机制研究
Nikita Agarwal,Uttam Sharma,Akshi Shree et al.
Nikita Agarwal et al.
Mitochondrial translation relies on the coordinated activity of mitoribosomes, mitochondrial ribosome proteins, mitochondria-specific transfer RNAs, and dedicated translation factors, including mitochondrial initiation factor 2/3, mitochond...
Post-treatment triglyceride-glucose index as survival protective factors in patients with esophageal squamous cell carcinoma [0.03%]
术后甘油三酯-葡萄糖指数作为食管鳞癌患者的生存保护因素
Ling Xiao,Yu-Di Liu,Xue Zhang et al.
Ling Xiao et al.
Background: Patients with esophageal cancer exhibit marked variability in prognosis, highlighting the need for metabolism-related biomarkers. Although metabolic reprogramming is considered to be correlated with the progno...
Yu Wang,Zhe Wang,Yue-Cui Tang et al.
Yu Wang et al.
Background: Adult sacrococcygeal teratoma (SCT) is extremely rare in clinical practice, with most cases manifesting as mature cystic types. Given the scarcity of clinical studies and literature on this topic, standardized...
Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms [0.03%]
PD-L1/PD-1共表达和CXCR3驱动的炎性特征在埃及淋巴增生性疾病患者中的预后意义
Dalia E Sherief,Nahla Nosair,Aya Mohammed Abdelhameed et al.
Dalia E Sherief et al.
Background: Lymphoproliferative neoplasms (LPNs) such as chronic lymphocytic leukemia and non-Hodgkin lymphomas are clinically heterogeneous and frequently associated with recurrence and poor outcomes. Immune checkpoint m...
Myeloid sarcoma transformed from myeloproliferative neoplasm: A case report and review of literature [0.03%]
由骨髓增殖性肿瘤转化而来的粒细胞肉瘤一例报道及文献复习
Shu-Han Zhong,Jie Lou,Ai-Qi Zhao et al.
Shu-Han Zhong et al.
Background: Myeloid sarcoma (MS) is a rare hematological malignancy that may be associated with myelodysplastic or myeloproliferative neoplasms. Herein, we report a case of transformation from myelofibrosis to MS. ...
Immune landscape of melanoma: Tumor microenvironment, resistance mechanisms, and predictive biomarkers [0.03%]
黑色素瘤的免疫图谱：肿瘤微环境、抗性机制和预测生物标志物
Marina M G L Oliveira,Carol S Lemos,Mariangela L S Brazão et al.
Marina M G L Oliveira et al.
Melanoma, a highly immunogenic malignancy, has become a paradigm for immune-based therapies. Despite remarkable responses to immune checkpoint inhibitors, many patients exhibit primary or acquired resistance. These outcomes are largely driv...
Obesity and colorectal cancer risk: A systematic review and meta-analysis [0.03%]
肥胖与结直肠癌风险的相关性：系统评价和Meta分析
Lachlan James Chun-Lok Leung,Rohan Sharad Sharma,Brandon Cheng et al.
Lachlan James Chun-Lok Leung et al.
Background: An observed correlation between increased colorectal cancer (CRC) incidence in patients with obesity [body mass index (BMI) ≥ 30 kg/m2] has been identified in past literature. However, there has been limited ...
Arterial and biliary complications after transarterial chemoembolization for hepatocellular carcinoma [0.03%]
经导管动脉化疗栓塞治疗肝细胞癌后的动脉和胆道并发症
Yan-Xin Wan,Zhen-Yi Lin,Lin-Tao Chen et al.
Yan-Xin Wan et al.
Transarterial chemoembolization is a common treatment modality that significantly improves prognosis in patients with intermediate-advanced hepatocellular carcinoma. However, this procedure is associated with a spectrum of potential arteria...
Role of nanotechnology in modulating the tumor microenvironment to enhance immunotherapy efficacy [0.03%]
纳米技术在重塑肿瘤微环境和增强免疫治疗效果方面的应用
Ayushi Jain,Saloni Verma,Alisha Jadhav et al.
Ayushi Jain et al.
The immunosuppressive tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC) is marked by hypoxia, acidity, and abundant stromal cells, such as cancer-associated fibroblasts, tumor-associated macrophages, and myeloid-derived su...