Immune landscape of melanoma: Tumor microenvironment, resistance mechanisms, and predictive biomarkers [0.03%]
黑色素瘤的免疫图谱：肿瘤微环境、抗性机制和预测生物标志物
Marina M G L Oliveira,Carol S Lemos,Mariangela L S Brazão et al.
Marina M G L Oliveira et al.
Melanoma, a highly immunogenic malignancy, has become a paradigm for immune-based therapies. Despite remarkable responses to immune checkpoint inhibitors, many patients exhibit primary or acquired resistance. These outcomes are largely driv...
Obesity and colorectal cancer risk: A systematic review and meta-analysis [0.03%]
肥胖与结直肠癌风险的相关性：系统评价和Meta分析
Lachlan James Chun-Lok Leung,Rohan Sharad Sharma,Brandon Cheng et al.
Lachlan James Chun-Lok Leung et al.
Background: An observed correlation between increased colorectal cancer (CRC) incidence in patients with obesity [body mass index (BMI) ≥ 30 kg/m2] has been identified in past literature. However, there has been limited ...
Arterial and biliary complications after transarterial chemoembolization for hepatocellular carcinoma [0.03%]
经导管动脉化疗栓塞治疗肝细胞癌后的动脉和胆道并发症
Yan-Xin Wan,Zhen-Yi Lin,Lin-Tao Chen et al.
Yan-Xin Wan et al.
Transarterial chemoembolization is a common treatment modality that significantly improves prognosis in patients with intermediate-advanced hepatocellular carcinoma. However, this procedure is associated with a spectrum of potential arteria...
Role of nanotechnology in modulating the tumor microenvironment to enhance immunotherapy efficacy [0.03%]
纳米技术在重塑肿瘤微环境和增强免疫治疗效果方面的应用
Ayushi Jain,Saloni Verma,Alisha Jadhav et al.
Ayushi Jain et al.
The immunosuppressive tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC) is marked by hypoxia, acidity, and abundant stromal cells, such as cancer-associated fibroblasts, tumor-associated macrophages, and myeloid-derived su...
Development and internal validation of an immune-based prognostic modeling of early-onset colorectal cancer via machine learning [0.03%]
基于免疫的早期结直肠癌预后机器学习模型的开发和内部验证
Xiu Chen,Yong Wang,Heng-Yang Shen et al.
Xiu Chen et al.
Background: Early-onset colorectal cancer (EOCRC) is an aggressive malignancy with rising incidence and poor prognosis in young adults. Circulating immune cells may hold prognostic value, yet their role in EOCRC outcomes ...
Acute exercise-induced catecholaminergic responses after 16 weeks of community-based exercise training in early-stage breast cancer survivors [0.03%]
社区活动训练方案对乳腺癌患者交感神经活性的影响研究
Jeb F Struder,Aiden J Chauntry,Lauren C Bates-Fraser et al.
Jeb F Struder et al.
Background: Breast cancer survivors (BCS) demonstrate attenuated immune cell mobilization following acute exercise, with partial restoration following exercise training. Epinephrine (EPI) and norepinephrine (NE) are respo...
Evaluating murine double minute 2 status as a stratification tool for risk-adapted management in plasma cell neoplasms [0.03%]
评估组蛋白变体H3.3K27M状态作为分层工具以指导对多发性髓系肿瘤的风险适应性管理
Noura A A Ebrahim,Habiba Elfandy,Aya Mohamed Adel Arafat et al.
Noura A A Ebrahim et al.
Background: The E3 ubiquitin ligase murine double minute 2 (MDM2) is a key negative regulator of the tumor suppressor protein p53 and has been implicated in the development of various cancers, including hematologic malign...
Endoscopic submucosal dissection in early esophageal neoplasia: Celebrating efficacy, confronting heterogeneity, and refining surveillance for high-risk patients [0.03%]
内镜下粘膜下剥离术治疗早期食管肿瘤：庆祝其疗效，面对异质性，并为高危患者完善随访监测策略
Shi-Qiong Zhou,Qing-Hua Ke
Shi-Qiong Zhou
Esophageal cancer poses a severe global healthcare burden, with a dismal prognosis primarily due to late-stage diagnosis - only 10%-30% of patients survive 5 years when symptoms trigger medical attention. Endoscopic submucosal dissection (E...
Liquid biopsy in genitourinary cancers: Diagnostic and prognostic implications [0.03%]
液态活检在泌尿生殖系统肿瘤中的诊断及预后价值
Joe Youssef,Amani Yehya,Zahraa Salhab et al.
Joe Youssef et al.
Genitourinary neoplasms, including bladder, prostate, renal, and testicular cancers, represent 25% of all solid tumors worldwide. Great advances have been achieved in the last few decades in diagnostic and therapeutic modalities. Among thes...
Endoscopic submucosal dissection and hybrid endoscopic submucosal dissection for stage 1 rectal neuroendocrine tumors [0.03%]
内镜下粘膜下挖除术与杂交内镜粘膜下挖除术治疗I期直肠神经内分泌肿瘤
Xue-Yan Qiao,Xiu-Jiao Shen,Yan-Hua Lv et al.
Xue-Yan Qiao et al.
Background: The technical complexity and potential for complications associated with endoscopic submucosal dissection (ESD) pose limitations on the widespread use of this procedure for stage 1 rectal neuroendocrine tumors...