Cancer stem cell markers, chemotherapy response, and survival in triple-negative breast cancer [0.03%]
三阴性乳腺癌中的癌症干细胞标志物、化疗反应及生存率关系研究
Faisal Nabi Depar,Ahmed Jamal Chaudhary,Jawad Hameed et al.
Faisal Nabi Depar et al.
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options, primarily relying on chemotherapy, yet often leading to recurrence due to chemoresistance. Cancer stem cells (CSC...
Small bowel lymphatic malformation: Clinical presentation and a comprehensive literature review [0.03%]
小肠淋巴管畸形的临床表现及文献综述
Harbi Khalayleh,Raneem Bader,Muhannad Abu Arafeh et al.
Harbi Khalayleh et al.
Small bowel lymphatic malformations are rare benign tumors of the lymphatic system, accounting for < 1% of intra-abdominal lymphatic malformations. They pose diagnostic challenges due to nonspecific presentations and are often misdiagnosed....
Palpable vs non-palpable breast cancers in screened populations: Clinicopathological features and prognostic implications [0.03%]
乳腺癌筛查人群中可触及与不可触及乳腺癌的临床病理特征及预后意义分析
Luca Improta,Gianluca Stanzani,Valeria Vitale et al.
Luca Improta et al.
Background: Despite widespread mammographic screening, a substantial proportion of breast cancers are still diagnosed as palpable lesions, frequently self-detected by the patient. Prior studies have investigated palpabili...
Intermittent fasting enhances cancer therapy via autophagy-dependent and independent mechanisms: Evidence and implications [0.03%]
间歇性断食通过自噬依赖性和非依赖性机制增强癌症治疗：证据及意义
Mona Mohamed Ibrahim Abdalla,Payal Bhatnagar,Mohd Hazim Bin Zulkaflee et al.
Mona Mohamed Ibrahim Abdalla et al.
Macroautophagy (hereafter referred to as autophagy) is a lysosomal degradation pathway that clears and recycles cytosolic oncogenic factors, excess lipids, and damaged mitochondria, thereby potentially preventing cancer initiation. Recent s...
Role of claudin-6 in high-grade endometrial carcinoma: Implications for risk stratification and personalized treatment strategies [0.03%]
Claudin-6在高级别子宫内膜癌中的作用：风险分层和个性化治疗策略的启示
Chuang Cai,Jin-Man Chen,Zu-Xun Qiu et al.
Chuang Cai et al.
This commentary discusses the groundbreaking study by Ebrahim et al on the role of claudin-6 (CLDN6) in high-grade endometrial carcinoma, addressing a significant gap in current knowledge. Their research reveals that overexpression of CLDN6...
Advances and challenges of chimeric antigen receptor T cell therapy in digestive system malignancies [0.03%]
嵌合抗原受体T细胞治疗消化系统肿瘤的进展与挑战
Chen Wang,Jin Zhang,Zi-Ke Chen et al.
Chen Wang et al.
Chimeric antigen receptor T cell therapy (CAR-T) has revolutionized the treatment of hematologic malignancies, but its success in solid tumors, particularly those of the digestive system, remains limited. Tumors of the gastrointestinal syst...
Ibrahim O Sawaied,Abraham O Samson,Efrat Golan
Ibrahim O Sawaied
Background: Long-term proton pump inhibitor (PPI) therapy is widely prescribed for acid-related disorders. Emerging evidence associates prolonged use with potential adverse outcomes, including gastric cancer. Despite incr...
Ferritin as a novel predictive index for nasopharyngeal carcinoma survival and therapeutic efficacy of different chemotherapy regimens [0.03%]
铁蛋白可作为鼻咽癌生存预测及不同化疗方案疗效评估的新指标
Qi Tang,Yao Wu,Lin Chen et al.
Qi Tang et al.
Background: In the treatment of nasopharyngeal carcinoma (NPC), there is a lack of effective assessment of the long-term effects on patients. Searching for an effective evaluation scheme and screening a reliable index for...
Beyond sensitivity and specificity: Redefining the era connotation of "low-risk" in pancreatic cancer screening [0.03%]
超越灵敏度和特异度：重新定义胰腺癌筛查中“低风险”的时代内涵
Rui-Gang Wang
Rui-Gang Wang
Pancreatic cancer remains a highly lethal malignancy, primarily due to late-stage diagnosis. Current screening paradigms, which focus exclusively on high-risk individuals, leave the vast "low-risk" population unscreened. This conventional b...
Kita-Kyushu lung cancer antigen-1 expression in initial gastric tumors predicts multiple cancer development: A pilot study [0.03%]
基塔九州肺癌抗原1在初始胃肿瘤中的表达预测多发癌的发生：一项初步研究
Nobue Futawatari,Takashi Fukuyama,Yusuke Akimoto et al.
Nobue Futawatari et al.
Background: We have previously reported that the cancer/testis antigen Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is frequently expressed in gastric cancer (GC), with a particularly high positivity rate observed in patie...