Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity [0.03%]
碱基切除修复基因多态性与乳腺癌风险及个体放射敏感性的关系研究
Clarice Patrono,Silvia Sterpone,Antonella Testa et al.
Clarice Patrono et al.
Breast cancer (BC) is the most common cancer among women worldwide. The aetiology and carcinogenesis of BC are not clearly defined, although genetic, hormonal, lifestyle and environmental risk factors have been established. The most common ...
Tumour suppressor HLJ1: A potential diagnostic, preventive and therapeutic target in non-small cell lung cancer [0.03%]
肿瘤抑制因子HLJ1：非小细胞肺癌的潜在诊断、预防和治疗靶点
Meng-Feng Tsai,Chi-Chung Wang,Jeremy Jw Chen
Meng-Feng Tsai
Lung cancer is the leading cause of cancer-related mortality throughout the world. Non-small cell lung cancer (NSCLC) accounts for 85% of all diagnosed lung cancers. Despite considerable progress in the diagnosis and treatment of the diseas...
Erlotinib usage after prior treatment with gefitinib in advanced non-small cell lung cancer: A clinical perspective and review of published literature [0.03%]
吉非替尼治疗失败的晚期非小细胞肺癌患者再次使用厄洛替尼临床疗效分析及文献回顾
Navneet Singh,Aditya Jindal,Digambar Behera
Navneet Singh
Erlotinib and gefitinib are among the most widely researched, used and available molecularly targeted therapies for treatment of advanced non-small cell lung cancer (NSCLC). They are both tyrosine kinase inhibitors (TKIs) of the epidermal g...
Palliative radiotherapy for bone metastases from lung cancer: Evidence-based medicine? [0.03%]
基于证据的医学在晚期肺癌骨转移中的姑息性放疗作用的评价
Alysa Fairchild
Alysa Fairchild
To review current recommendations for palliative radiotherapy for bone metastases secondary to lung cancer, and to analyze surveys to examine whether global practice is evidence-based, English language publications related to best practice ...
Positron emission tomography to assess hypoxia and perfusion in lung cancer [0.03%]
正电子发射体层摄影在肺癌肿瘤低氧状况和灌注评估中的应用
Eline E Verwer,Ronald Boellaard,Astrid Am van der Veldt
Eline E Verwer
In lung cancer, tumor hypoxia is a characteristic feature, which is associated with a poor prognosis and resistance to both radiation therapy and chemotherapy. As the development of tumor hypoxia is associated with decreased perfusion, perf...
Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants [0.03%]
由非小细胞肺癌表皮生长因子受体突变引起的肿瘤发生信号转导和内吞作用的关系
Byung Min Chung,Eric Tom,Neha Zutshi et al.
Byung Min Chung et al.
Epidermal growth factor receptor (EGFR) controls a wide range of cellular processes, and aberrant EGFR signaling as a result of receptor overexpression and/or mutation occurs in many types of cancer. Tumor cells in non-small cell lung cance...
Milena Králíčková,Vaclav Vetvicka
Milena Králíčková
Endometriosis is the leading cause of morbidity among premenopausal women and the complex pathogenesis of this disease remains controversial despite extensive research. This disease represents one of the most common gynecological problems. ...
Emerging gene-based prognostic tools in early breast cancer: First steps to personalised medicine [0.03%]
基于基因的早期乳腺癌预后工具的发展：迈向个性化医疗的第一步
Umar Wazir,Kefah Mokbel
Umar Wazir
Breast cancer remains a major cause of neoplastic disease in much of the developed world. The majority of cases are diagnosed with oestrogen receptor (ER)-positive and human epidermal growth factor receptor-2 negative invasive ductal carcin...
Towards optimal management of the axilla in the context of a positive sentinel node biopsy in early breast cancer [0.03%]
前哨淋巴结活检阳性的早期乳腺癌患者的腋窝治疗展望
Umar Wazir,Aisling Manson,Kefah Mokbel
Umar Wazir
The sentinel lymph node biopsy (SLNB) was initially pioneered for staging melanoma in 1994 and it has been subsequently validated by several trials, and has become the new standard of care for patients with clinically node negative invasive...
Clinical and scientific impact of human papillomavirus on head and neck cancer [0.03%]
人乳头瘤病毒对头颈部癌症的临床和科学影响
Jeffrey M Friedman,Mark J Stavas,Anthony J Cmelak
Jeffrey M Friedman
Head and neck cancer (HNC) arises from the skull base to the clavicles and is the fifth most common cancer in the world by incidence. Historically, in the developed world HNC was associated with tobacco use and alcohol consumption, and the ...