From mutational signatures to practice: Artificial intelligence-guided repurposing for blast crisis chronic myeloid leukemia [0.03%]
从突变特征到实践：人工智能引导的药物再利用在急变期慢性髓性白血病中的应用
Riya Karmakar,Aditya Kandalkar,Hsiang-Chen Wang et al.
Riya Karmakar et al.
This article of discusses blast crisis chronic myeloid leukemia (CML), which is the most aggressive CML phase marked by rapid progression, substantial mutational complexity, and resistance to standard tyrosine kinase therapies. The methodol...
Immunosuppressive tumor microenvironment shape pancreatic cancer unresponsive to current immunotherapies [0.03%]
免疫抑制性肿瘤微环境导致胰腺癌无法对现有免疫疗法产生反应
Zong-Yang Li,Si-Yu Peng,Fei-Long Li et al.
Zong-Yang Li et al.
Pancreatic ductal adenocarcinoma remains largely refractory to current immunotherapies due to a profoundly immunosuppressive tumor microenvironment dominated by regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and tumor...
Chi Zhang,Hao Wang,Yan-Hui Yang
Chi Zhang
Pancreatic cancer (PC) represents one of the most formidable challenges in oncology, necessitating continuous innovation in therapeutic strategies. Owing to its pivotal role in PC progression, lipid metabolism, which is characterized by dys...
Microenvironment plays a critical role in modulating tumor cell dormancy: Current perspectives and potential treatment options [0.03%]
微环境在调节肿瘤细胞休眠中起关键作用：当前观点及潜在治疗选择展望
Ye-Rong Qian,Peng Liu,Hui Xu et al.
Ye-Rong Qian et al.
Tumor dormancy is a fundamental phenomenon in cancer biology, characterized by malignant cells that remain viable but non-proliferative, thereby frequently evading detection and treatment. This review examines the intricate role of the tumo...
T cell exhaustion markers in hepatitis C virus-related hepatocellular carcinoma: Expression patterns and prognostic significance in an Egyptian cohort [0.03%]
埃及肝细胞癌患者队列中与丙型肝炎病毒感染相关的T细胞耗竭标志物：表达模式和预后价值
Asmaa M Hasan,Sara M F I Ghanem,Amira A A Othman et al.
Asmaa M Hasan et al.
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, particularly in Egypt, where hepatitis C virus (HCV) prevalence is high. T cell exhaustion markers such as programmed death 1 (PD-...
Gene and cytokine expression profiles of metastatic colorectal cancer patients post reovirus administration [0.03%]
雷托病毒治疗后转移性结直肠癌患者的基因和细胞因子表达谱分析
Vivian Zweig,Sanjay Goel,Radhashree Maitra
Vivian Zweig
Background: Colorectal cancer (CRC), encompassing both colon and rectal carcinogenesis, is a major health concern. Metastatic CRC (mCRC) is the third most common cancer and the second leading cause of cancer-related death...
Effects of electroacupuncture combined with flurbiprofen axetil on postoperative pain and early functional recovery after breast cancer surgery [0.03%]
电针联合氟比洛芬酯对乳腺癌术后镇痛及早期功能康复的影响
Bi-Mei He,Xiao-Lin Sun,Xiao-Yu Huang et al.
Bi-Mei He et al.
Background: Breast cancer surgery often leads to acute postoperative pain that affects early recovery. Electroacupuncture (EA) is a potential adjunct to analgesics such as flurbiprofen axetil (FA), but evidence on its per...
Thyroid cancer in Chinese military flight personnel: Characteristics and management advances [0.03%]
中国军人飞行员甲状腺癌的特征和诊治进展
Yan Wang,Jing Liu,Chun-Xia Zhang et al.
Yan Wang et al.
Military flight personnel face a higher risk of developing thyroid cancer than the general population due to prolonged exposure to unique occupational hazards, including high-altitude hypoxia, ionizing radiation, extreme physiological and p...
Common gamma chain cytokines-driven optimization of chimeric antigen receptor T cells: Mechanistic insights and future directions [0.03%]
共通γ链细胞因子驱动的嵌合抗原受体T细胞优化：机制见解和未来方向
Dian-Bao Zuo,Zi-Hao Chen,Yu-Meng Jin et al.
Dian-Bao Zuo et al.
Malignant tumors represent a major threat to human life and health, posing persistent challenges in medical research. While chimeric antigen receptor T (CAR-T) cell therapy has demonstrated breakthrough efficacy in hematological malignancie...
Perineural invasion in digestive tract tumors: Immune system interactions and therapeutic strategies [0.03%]
消化道肿瘤的癌周神经侵犯：免疫系统相互作用及治疗策略
Jia-Yu Pang,Rong-Yao Jin,Han-Xiao Zhang et al.
Jia-Yu Pang et al.
Digestive tract tumors represent a substantial global public health challenge, accounting for elevated morbidity and mortality rates. Perineural invasion (PNI), the spread of tumor cells along nerve fibers, has emerged as a key driver of ag...