Differential regulation of mitochondrial quality control in skeletal muscle by HZE radiation exposure and partial weightbearing in mice [0.03%]
重离子辐射暴露和部分负重对小鼠骨骼肌线粒体质量控制的差异化调节作用
Carla Mc Nascimento,James D Fluckey,Florence Lima et al.
Carla Mc Nascimento et al.
Spaceflight places astronauts under both reduced mechanical loading and ionizing radiation, each of which can compromise skeletal muscle health. We investigated whether 21 days of simulated lunar gravity (one sixth G) with or without a sing...
Simulated Microgravity affects immune reaction to infection through altering lymphocyte differentiation, cytokine secretion, and macrophage polarization [0.03%]
模拟微重力通过改变淋巴细胞分化、细胞因子分泌和巨噬细胞极化来影响对感染的免疫反应
Hongyan Cai,Rui Jia,Huimin Chen et al.
Hongyan Cai et al.
Microgravity is one of the most significant hazards during spaceflight, as prolonged exposure to the microgravity environment impairs the immune system and increases the risk of infection. Extensive research on the effects of microgravity o...
Effects of social isolation alone and combined with15cGy GCRsim Space radiation on fear conditioned behavioral, stress and sleep responses [0.03%]
社会隔离和15cGy空间辐射联合刺激对恐惧条件化行为、压力及睡眠反应的影响
Larry D Sanford,Austin M Adkins,Alea F Boden et al.
Larry D Sanford et al.
Astronauts on deep space missions will be exposed to physical and psychological stressors, including space radiation (SR) and periods of social isolation (SI). The effects of these inflight stressors can be complex because they have differe...
Dose-specific lncRNA-mRNA networks modulate DNA damage and immune responses in CD4⁺ T cells under simulated space UVC irradiation [0.03%]
剂量依赖的长链非编码RNAs及其靶mRNAs调控CD4⁺T细胞DNA损伤及免疫反应
Xiaolin Ding,Yue Pang,Boxiang Zhang et al.
Xiaolin Ding et al.
Ultraviolet-C (UVC) irradiation is a prevalent component of the extraterrestrial radiation spectrum. To explore how long non-coding RNAs (lncRNAs) orchestrate cellular responses under simulated space UVC radiation, we exposed human CD4⁺ T ...
From Antarctic regolith to lunar greenhouses: Mechanistic insights into Brassica rapa photosystem II dynamics for sustainable space agriculture [0.03%]
从南极风化层到月球温室：拟南芥光系统II动态的机制见解，用于可持续的空间农业
Syed Inzimam Ul Haq,Josef Hájek,Miloš Barták
Syed Inzimam Ul Haq
Sustainable agriculture systems utilizing in-situ resources are crucial for future human missions to the Moon and Mars. Antarctic regolith, a terrestrial analog of lunar soil, offers an opportunity to understand how plants respond physiolog...
Approaching ocular risks during spaceflight with 3D printing: Technical strategies to protect astronaut vision [0.03%]
太空飞行期间利用3D打印技术保护宇航员视力的措施及策略来应对眼部风险
Saif Pasha,Joshua Ong,Yannie Guo et al.
Saif Pasha et al.
Long-duration spaceflight poses significant risks to ocular health due to prolonged microgravity exposure and space environmental stressors, contributing to conditions such as Spaceflight-Associated Neuro-ocular Syndrome (SANS) and Spacefli...
Plasma exchange as a neuroprotective strategy for post-spaceflight neuroinflammation in astronauts [0.03%]
航天员飞行后神经炎症的神经保护策略——血浆交换疗法
Yamac Akgun
Yamac Akgun
Extended space missions, such as upcoming crewed explorations to Mars, pose significant physiological challenges, including neuroinflammation due to microgravity, cosmic radiation, and prolonged confinement. This article explores therapeuti...
An emerging paradigm for scientific decision: the AI evaluation of space science projects [0.03%]
空间科学项目的人工智能评估——科学决策中的新兴范式
Qiwen Deng,Yanzhong Wen,Chaosen Liu et al.
Qiwen Deng et al.
In the past six decades, the progress of spaceflight projects has won the admiration of the whole world. However, how to evaluate the values of research projects remains an esoteric and cost effective question. To improve the selections in ...
Directional astronaut radiation dose for hemispherical galactic cosmic ray irradiation [0.03%]
半球形银河宇宙射线辐射下的定向宇航员辐射剂量
Ran Huo,Songying Xu,Xuemei Chen
Ran Huo
While galactic cosmic rays (GCRs) are inherently isotropic, in several important cases they are constrained to certain solid angle region. This directional irradiation leads to non-trivial deviations in radiation exposure from simple solid ...