Pomegranate extract inhibits EMT in clear cell renal cell carcinoma in a NF-κB and JNK dependent manner [0.03%]
石榴提取物通过依赖NF-κB和JNK的方式抑制透明细胞肾细胞癌的上皮间质转化
Jiabin An,Yanchuan Guo,Ting Wang et al.
Jiabin An et al.
Objective: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC) and is characterized by biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. One effect o...
Bilal Chughtai,Aizaz Ali,Claire Dunphy et al.
Bilal Chughtai et al.
Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including c...
Christopher Hartman,Nikhil Gupta,David Leavitt et al.
Christopher Hartman et al.
Treatment of large renal stones has changed considerably in recent years. The increasing prevalence of nephrolithiasis has mandated that urologists perform more surgeries for large renal calculi than before, and this has been met with impro...
Sumanta K Pal,Paulo Bergerot,Robert A Figlin
Sumanta K Pal
Systemic therapy for metastatic renal cell carcinoma (mRCC) has evolved drastically, with agents targeting vascular endothelial growth factor (VEGF) and the mammalian target of rapamycin (mTOR) now representing a standard of care. The prese...
The growth of computer-assisted (robotic) surgery in urology 2000-2014: The role of Asian surgeons [0.03%]
泌尿外科的计算机辅助（机器人）手术的发展（2000年-2014年）：亚洲医生的角色
Deepansh Dalela,Rajesh Ahlawat,Akshay Sood et al.
Deepansh Dalela et al.
Objective: A major role in the establishment of computer-assisted robotic surgery (CARS) can be traced to the work of Mani Menon at Vattikuti Urology Institute (VUI), and of many surgeons of Asian origin. The success of r...
Zheng Cao,Natasha Kyprianou
Zheng Cao
Few pharmacotherapies are currently available to treat castration resistant prostate cancer (CRPC), with low impact on patient survival. Transforming growth factor-β (TGF-β) is a multi-functional peptide with opposite roles in prostate tu...
Adaptive pathways and emerging strategies overcoming treatment resistance in castration resistant prostate cancer [0.03%]
适应性途径及克服去势抵抗性前列腺癌治疗耐药性的新策略
Cameron M Armstrong,Allen C Gao
Cameron M Armstrong
The therapies available for prostate cancer patients whom progress from hormone-sensitive to castration resistant prostate cancer include both systemic drugs, including docetaxel and cabazitaxel, and drugs that inhibit androgen signaling su...
Jin Xu,Yun Qiu
Jin Xu
Prostate cancer (PCa) is one of the most lethal cancers in western countries. Androgen receptor (AR) signaling pathway plays a key role in PCa progression. Despite the initial effectiveness of androgen deprivation therapy (ADT) for treatmen...