Louis R Kavoussi
Louis R Kavoussi
Metastasis in renal cell carcinoma: Biology and implications for therapy [0.03%]
肾细胞癌转移的生物学特性及其对治疗的影响
Jun Gong,Manuel Caitano Maia,Nazli Dizman et al.
Jun Gong et al.
Although multiple advances have been made in systemic therapy for renal cell carcinoma (RCC), metastatic RCC remains incurable. In the current review, we focus on the underlying biology of RCC and plausible mechanisms of metastasis. We furt...
James L Gulley,Ravi A Madan
James L Gulley
The clinical development of immunotherapy has gained significant impetus in recent years across the field of medical oncology. Mounting preclinical and clinical data have demonstrated the potential of immune-based treatments to augment anti...
Novel immunotherapy approaches for metastatic urothelial and renal cell carcinoma [0.03%]
新型免疫疗法在转移性尿路上皮癌和肾细胞癌中的应用
Zhiying Shao,Andrew Z Wang,Daniel J George et al.
Zhiying Shao et al.
The treatment of metastatic renal cell carcinoma (RCC) and urothelial carcinoma (UC) remains a major challenge. Past research has implicated the immune system in tumor surveillance of both malignancies, leading to the application of immunot...
David J McConkey,Woonyoung Choi,Andrea Ochoa et al.
David J McConkey et al.
Recent studies demonstrated that bladder cancers can be grouped into basal and luminal molecular subtypes that possess distinct biological and clinical characteristics. Basal bladder cancers express biomarkers characteristic of cancer stem ...
Shirley Cheng,Jie-Fu Chen,Yi-Tsung Lu et al.
Shirley Cheng et al.
One of the major challenges that clinicians face is in the difficulties of accurately monitoring disease progression. Prostate cancer is among these diseases and greatly affects the health of men globally. Circulating tumor cells (CTCs) are...
Cultured circulating tumor cells and their derived xenografts for personalized oncology [0.03%]
循环肿瘤细胞培养及其异种移植体在个体化医学中的应用
Ruoxiang Wang,Gina C Y Chu,Stefan Mrdenovic et al.
Ruoxiang Wang et al.
Recent cancer research has demonstrated the existence of circulating tumor cells (CTCs) in cancer patient's blood. Once identified, CTC biomarkers will be invaluable tools for clinical diagnosis, prognosis and treatment. In this review, we ...
Specific bone region localization of osteolytic versus osteoblastic lesions in a patient-derived xenograft model of bone metastatic prostate cancer [0.03%]
骨转移性前列腺癌患者来源异种移植模型中破骨性和成骨性病变的特定骨区定位
Takeshi Hirata,Seung Chol Park,Michelle T Muldong et al.
Takeshi Hirata et al.
Objective: Bone metastasis occurs in up to 90% of men with advanced prostate cancer and leads to fractures, severe pain and therapy-resistance. Bone metastases induce a spectrum of types of bone lesions which can respond ...
Mismatch repair enzyme expression in primary and castrate resistant prostate cancer [0.03%]
原发和雄激素抵抗前列腺癌中的错配修复酶表达
Belinda Nghiem,Xiaotun Zhang,Hung-Ming Lam et al.
Belinda Nghiem et al.
Objective: Although the utility of immunohistochemistry (IHC) for assessing mismatch repair (MMR) protein expression has been demonstrated in solid tumors including primary prostate cancer (PCa), its utility has not been ...
Takashi Kobayashi
Takashi Kobayashi
Management of unresectable urothelial cancer (UC) has been a clinical challenge for decades. While drug resistance is a key issue, precise understanding of biology of UC metastasis is another challenge for the improvement of treatment outco...