Enhanced production of camptothecin by immobilized callus of Ophiorrhiza mungos and a bioinformatic insight into its potential antiviral effect against SARS-CoV-2 [0.03%]
一种防己属植物愈伤组织的固定化培养及其产物 Camptothecin 的增强生产及生物信息学视角下其对 SARS-CoV-2 潜在抗病毒活性研究
Rajesh Mamkulathil Devasia,Mohammad Altaf,Abdulwahed Fahad Alrefaei et al.
Rajesh Mamkulathil Devasia et al.
Camptothetin (CPT) is a quinoline alkaloid originally isolated from the Chinese tree, Camptotheca acuminata Decne. CPT was found to have anticancerous and antiviral properties. Derivatives of natural CPT, including topothecan and irinotecan...
Evaluating the potency of Sulawesi propolis compounds as ACE-2 inhibitors through molecular docking for COVID-19 drug discovery preliminary study [0.03%]
通过分子对接评估苏拉威西蜂胶化合物作为ACE-2抑制剂的潜力以用于COVID-19药物发现初步研究
Apriliana Cahya Khayrani,Rafidha Irdiani,Reza Aditama et al.
Apriliana Cahya Khayrani et al.
Coronavirus disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Up to date, there has been no specific cure to treat the disease. Indonesia is one of the countries that is still fi...
Probiotic lactobacilli: Can be a remediating supplement for pandemic COVID-19. A review [0.03%]
益生乳酸菌可作为大流行性COVID-19的补救补充剂。综述一篇
Mysoon M Al-Ansari,Samer A Sahlah,Lateefah AlHumaid et al.
Mysoon M Al-Ansari et al.
In recent years increased attention is focussed on microorganisms inhabiting the digestive system that provides prophylactic and therapeutic benefits to the host. After Metchnikoff exposed the secret behind Bulgarian peasants' extended long...
Comparison of the SARS-CoV-2 (2019-nCoV) M protein with its counterparts of SARS-CoV and MERS-CoV species [0.03%]
SARS-CoV-2(2019-nCoV)的M蛋白与其他冠状病毒物种的比较分析
Sultan Nafea Alharbi,Abdulwahed Fahad Alrefaei
Sultan Nafea Alharbi
Coronaviruses M proteins are well-represented in the major protein component of the viral envelope. During the viral assembly, they play an important role by association with all other viral structural proteins. Despite their crucial functi...
Quantum chemical studies on molecular structure, AIM, ELF, RDG and antiviral activities of hybrid hydroxychloroquine in the treatment of COVID-19: Molecular docking and DFT calculations [0.03%]
量子化学研究羟氯喹杂合物的分子结构、AIM、ELF、RDG及抗病毒活性在治疗COVID-19中的作用：分子对接和DFT计算
Olfa Noureddine,Noureddine Issaoui,Mouna Medimagh et al.
Olfa Noureddine et al.
Structure-activity relationships for hydroxychloroquine compound and its derivatives resulted in a potent antiviral activity. Where hydroxychloroquine derivatives showed an apparent efficacy against coronavirus related pneumonia. For this r...
Computational investigations of three main drugs and their comparison with synthesized compounds as potent inhibitors of SARS-CoV-2 main protease (Mpro): DFT, QSAR, molecular docking, and in silico toxicity analysis [0.03%]
三种主要药物的计算研究及其与合成化合物作为SARS-CoV-2主要蛋白酶(Mpro)有效抑制剂的比较：DFT、QSAR、分子对接和计算机毒性分析
Ranjan K Mohapatra,Lina Perekhoda,Mohammad Azam et al.
Ranjan K Mohapatra et al.
In this study, we examined five previously synthesized compounds and checked their binding affinity towards the SARS-CoV-2 main protease (Mpro) by molecular docking study, and compared the data with three FDA approved drugs, i.e., Remdesivi...
Psychological well-being during COVID-19 lockdown: Insights from a Saudi State University's Academic Community [0.03%]
沙特州立大学学术社区COVID-19封锁期间的心理健康状况研究报告
Hanan A Alfawaz,Kaiser Wani,Abdulaziz A Aljumah et al.
Hanan A Alfawaz et al.
Objectives: Measures to control the on-going COVID-19 pandemic such as quarantine and social distancing, together with information overload about the sporadic spread of the disease have negatively impacted many individual...
Evaluating antibody response pattern in asymptomatic virus infected pregnant females: Human well-being study [0.03%]
评估无症状病毒感染的孕妇的抗体反应模式：人类福祉研究
Ashaq Ali,Zubia Rashid,Jieqiong Zhou et al.
Ashaq Ali et al.
The ongoing SARS-CoV-2 pandemic infecting millions of people globally has given rise to serious public health threats. The need for early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic pregnant wom...
DFT and molecular docking study of chloroquine derivatives as antiviral to coronavirus COVID-19 [0.03%]
氯喹衍生物作为抗冠状病毒COVID-19的药物的密度泛函理论和分子对接研究
Olfa Noureddine,Noureddine Issaoui,Omar Al-Dossary
Olfa Noureddine
The recently emerged COVID-19 virus caused hundreds of thousands of deaths and instigated a widespread fear, threatening the world's most advanced health security. In 2020, chloroquine derivatives are among the drugs tested against the coro...
Molecular interaction analysis of Sulawesi propolis compounds with SARS-CoV-2 main protease as preliminary study for COVID-19 drug discovery [0.03%]
苏拉维西蜂胶化合物与SARS-CoV-2主要蛋白酶分子互作分析作为COVID-19药物发现的初步研究
Muhamad Sahlan,Rafidha Irdiani,Darin Flamandita et al.
Muhamad Sahlan et al.
Coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health concern, as the World Health Organization declared this outbreak to be a global pandemic i...