A computational study of metal ions interaction with amyloid-β 1-42 peptide structure in hyperpyrexia: Implications for Alzheimer disease [0.03%]
高热条件下金属离子与淀粉样蛋白-β 1-42 肽结构相互作用的计算研究：阿尔茨海默病的含义
Cosmin Stefan Mocanu,Laura Darie-Ion,Brindusa Alina Petre et al.
Cosmin Stefan Mocanu et al.
Given the current context of the SARS-CoV-19 pandemic, among the interfering risky factors with the Aβ peptide aggregation in the brains of Alzheimer's disease (AD) patients can be hyperpyrexia and increased intracranial pressure (ICP). Ac...
Phytochemistry, biological activities and in silico molecular docking studies of Oxalis pes-caprae L. compounds against SARS-CoV-2 [0.03%]
Oxalis pes-caprae L.化合物对抗SARS-CoV-2的植物化学、生物活性及分子对接研究
Farhat Gul,Ilham Khan,Javed Iqbal et al.
Farhat Gul et al.
Phytochemicals are directly involved in therapeutic treatment or precursors to synthesize useful drugs. The current study was aimed to evaluate the phytocompounds and their biopotentials using methanolic and n-hexane extracts of various par...
The impact of physical activity on psychological well-being and perceived health status during coronavirus pandemic in university students [0.03%]
新冠肺炎疫情期间大学生身体活动对心理健康状况和自我健康感知的影响研究
Andrea Lukács
Andrea Lukács
Objectives: To investigate changes in moderate and vigorous physical activity (PA), and find correlation with psychological well-being and perceived health status in university students prior to versus 4-6 weeks following...
Molecular modelling and simulation techniques to investigate the effects of fungal metabolites on the SARS-CoV-2 RdRp protein inhibition [0.03%]
分子建模和模拟技术研究真菌代谢产物对SARS-CoV-2 RNA依赖性RNA聚合酶蛋白抑制作用的影响
Uday M Muddapur,Shrikanth Badiger,Ibrahim Ahmed Shaikh et al.
Uday M Muddapur et al.
Various protein/receptor targets have been discovered through in-silico research. They are expanding rapidly due to their extensive advantage of delivering new drug candidates more quickly, efficiently, and at a lower cost. The automation o...
Exploring the phytochemicals of Platycodon grandiflorus for TMPRSS2 inhibition in the search for SARS-CoV-2 entry inhibitors [0.03%]
基于TMPRSS2抑制的SARS-CoV-2入侵抑制剂筛选蔊菜植物化学成分研究
Arun Bahadur Gurung,Mohammad Ajmal Ali,Joongku Lee et al.
Arun Bahadur Gurung et al.
Platycodon grandiflorus (Jacq.) A. DC. (Campanulaceae) is commonly known as a balloon flower whose rhizomes have been widely utilized in traditional Chinese medicine (TCM) and in various Japanese prescriptions for the treatment of respirato...
Development of saline loaded mask materials, evaluation of the antimicrobial efficacy and survivability of selected bacteria on these mask materials [0.03%]
载盐口罩材料的开发及其抗菌功效和部分细菌在该口罩上存活情况的评价
Julnar Evangelista Pepito,Jayachandran Vavolil Prabhakaran,Dinesh Kada Peela Bheeman et al.
Julnar Evangelista Pepito et al.
Objective: Surgical face masks have been recommended by World Health Organization (WHO) during the COVID-19 pandemic. Nowadays wearing masks have become a norm and lifestyle around the globe. The present investigation was...
Encapsulation of MERS antigen into α-GalCer-bearing-liposomes elicits stronger effector and memory immune responses in immunocompetent and leukopenic mice [0.03%]
α-GalCer负载的脂质体包裹MERS抗原能够诱导免疫 competent和白细胞减少小鼠产生更强的效应和记忆性免疫应答
Masood Alam Khan,Arif Khan,Mohammad A Alzohairy et al.
Masood Alam Khan et al.
Objectives: Here, we prepared a liposome-based vaccine formulation containing Middle East Respiratory Syndrome Coronavirus papain-like protease (MERS-CoV-PLpro). ...
Computational studies on potential new anti-Covid-19 agents with a multi-target mode of action [0.03%]
具有多靶点作用机制的潜在新型抗新冠药物的计算研究
Ranjan K Mohapatra,Mohammad Azam,Pranab K Mohapatra et al.
Ranjan K Mohapatra et al.
A compound that could inhibit multiple targets associated with SARS-CoV-2 infection would prove to be a drug of choice against the virus. Human receptor-ACE2, receptor binding domain (RBD) of SARS-CoV-2 S-protein, Papain-like protein of SAR...
Scientific risk performance analysis and development of disaster management framework: A case study of developing Asian countries [0.03%]
科学的风险绩效分析及灾害管理体系框架的构建——以亚洲发展中国家为例
Chunhui Huo,Javaria Hameed,Ahsan Nawaz et al.
Chunhui Huo et al.
Disaster is a state of serious disruptions in the functionality of any society or county. Disasters pose serious economic or environmental impacts that surpass the capacity of the affected country or society to compete with the use of their...
In silico prediction and experimental evaluation of potential siRNAs against SARS-CoV-2 inhibition in Vero E6 cells [0.03%]
基于计算预测及实验验证的SARS-CoV-2感染细胞抑制型siRNA筛查分析
Sayed Sartaj Sohrab,Sherif Aly El-Kafrawy,Esam Ibraheem Azhar
Sayed Sartaj Sohrab
Objective: The acute cases of pneumonia (COVID-19) were first reported from China in December 2019, and the pathogen was identified as SARS-CoV-2. Currently, many vaccines have been developed against this virus by using m...