Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development [0.03%]
音速刺猬信号崭露头角：在新皮层发育中的新兴作用
Odessa R Yabut,Samuel J Pleasure
Odessa R Yabut
The mammalian neocortex is composed of a diverse population of neuronal and glial cells that are crucial for cognition and consciousness. Orchestration of molecular events that lead to the production of distinct cell lineages is now a major...
Non-canonical post-transcriptional RNA regulation of neural stem cell potential [0.03%]
神经干细胞潜能的非经典转录后RNA调控机制研究
Chiara Rolando,Verdon Taylor
Chiara Rolando
Adult brain structures and complexity emerge from a single layer of neuroepithelial cells that early during the development give rise to neural stem cells (NSCs). NSCs persist in restricted regions of the postnatal brain where they support ...
Autophagy and Adult Neurogenesis: Discoveries Made Half a Century Ago Yet in their Infancy of being Connected [0.03%]
自噬与成人神经发生：半个世纪前的发现，却才刚刚开始被联系在一起
Jagroop Dhaliwal,Laura Trinkle-Mulcahy,Diane C Lagace
Jagroop Dhaliwal
Within the brain, the physiological and pathological functions of autophagy in development and throughout the lifespan are being elucidated. This review summarizes recent in vitro and in vivo results that are defining the role of autophagy-...
Anna Lozano-Ureña,Raquel Montalbán-Loro,Anne C Ferguson-Smith et al.
Anna Lozano-Ureña et al.
Most genes required for mammalian development are expressed from both maternally and paternally inherited chromosomal homologues. However, there are a small number of genes known as "imprinted genes" that only express a single allele from o...
Ruth Beckervordersandforth
Ruth Beckervordersandforth
The life-long generation of new neurons from radial glia-like neural stem cells (NSCs) is achieved through a stereotypic developmental sequence that requires precise regulatory mechanisms to prevent exhaustion or uncontrolled growth of the ...
Marlen Knobloch
Marlen Knobloch
Neural stem/progenitor cells (NSPCs) give rise to billions of cells during development and are critical for proper brain formation. The finding that NSPCs persist throughout adulthood has challenged the view that the brain has poor regenera...
miRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Epilepsy [0.03%]
microRNA在成年海马神经发生中的介导调节作用；对癫痫的影响
Pascal Bielefeld,Catherine Mooney,David C Henshall et al.
Pascal Bielefeld et al.
Hippocampal neural stem/progenitor cells (NSPCs) proliferate and differentiate to generate new neurons across the life span of most mammals, including humans. This process takes place within a characteristic local microenvironment where NSP...
Avni Baser,Maxim Skabkin,Ana Martin-Villalba
Avni Baser
Adult neural stem cells are generated at embryonic stages by entering a quiescent state that allows their retention into adulthood and thereby maintenance of life-long brain homeostasis. Thus, a tight balance between the quiescence and acti...
Emily M Jobe,Xinyu Zhao
Emily M Jobe
The role of DNA methylation in brain development is an intense area of research because the brain has particularly high levels of CpG and mutations in many of the proteins involved in the establishment, maintenance, interpretation, and remo...
Regulation of Adult Neurogenesis 2.0 - Beyond Signaling Pathways and Transcriptional Regulators [0.03%]
成年人神经发生调节2.0-信号通路和转录调节因子之外
Helena Mira,D Chichung Lie
Helena Mira