The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging [0.03%]
运动的神经保护作用：保持大脑健康度老龄化
Laura M Vecchio,Ying Meng,Kristiana Xhima et al.
Laura M Vecchio et al.
Physical activity plays an essential role in maintaining a healthy body, yet it also provides unique benefits for the vascular and cellular systems that sustain a healthy brain. While the benefit of exercise has been observed in humans of a...
Insulin Peptides as Mediators of the Impact of Life Style in Alzheimer's disease [0.03%]
胰岛素肽在生活方式影响阿尔茨海默病中的介导作用
A M Fernandez,A Santi,I Torres Aleman
A M Fernandez
The search for the cause of Alzheimer's disease (AD), that affects millions of people worldwide, is currently one of the most important scientific endeavors from a clinical perspective. There are so many mechanisms proposed, and so disparat...
Henriette van Praag
Henriette van Praag
Regulation of Adult Neurogenesis by the Fragile X Family of RNA Binding Proteins [0.03%]
脆性X家族RNA结合蛋白对成人神经发生的作用机制研究
Natalie E Patzlaff,Minjie Shen,Xinyu Zhao
Natalie E Patzlaff
The fragile X mental retardation protein (FMRP) has an important role in neural development. Functional loss of FMRP in humans leads to fragile X syndrome, and it is the most common monogenetic contributor to intellectual disability and aut...
Crosstalk between MicroRNAs and Autophagy in Adult Neurogenesis: Implications for Neurodegenerative Disorders [0.03%]
microRNA与自噬在成人神经发生中的相互作用及其对神经退行性疾病的意义
Karolina Pircs,Rebecca Petri,Johan Jakobsson
Karolina Pircs
Adult neurogenesis in the mammalian brain, including in humans, occurs throughout life in distinct brain regions. Alterations in adult neurogenesis is a common phenomenon in several different neurodegenerative disorders, which is likely to ...
Hai T Vo,Ann M Laszczyk,Gwendalyn D King
Hai T Vo
Brain expression of klotho was first described with the initial discovery of the klotho gene. The prominent age-regulating effects of klotho are attributed to regulation of ion homeostasis through klotho function in the kidney. However, rec...
Contributions of Adult-Generated Granule Cells to Hippocampal Pathology in Temporal Lobe Epilepsy: A Neuronal Bestiary [0.03%]
成人生成的颗粒细胞在颞叶癫痫海马病变中的作用：神经元图鉴
Steve C Danzer
Steve C Danzer
Hippocampal neurogenesis continues throughout life in mammals - including humans. During the development of temporal lobe epilepsy, newly-generated hippocampal granule cells integrate abnormally into the brain. Abnormalities include ectopic...
Yoshio Takashima,Chitra D Mandyam
Yoshio Takashima
One of the consequences of chronic methamphetamine (Meth) abuse and Meth addiction is impaired hippocampal function which plays a critical role in enhanced propensity for relapse. This impairment is predicted by alterations in hippocampal n...
Patrik Hollos,Francesca Marchisella,Eleanor T Coffey
Patrik Hollos
Depression and anxiety are the most common mood disorders affecting 300 million sufferers worldwide. Maladaptive changes in the neuroendocrine stress response is cited as the most common underlying cause, though how the circuits underlying ...
The Hippocampal Neuro-Glio-Vascular Network: Metabolic Vulnerability and Potential Neurogenic Regeneration in Disease [0.03%]
海马神经-胶质-血管网络：代谢脆弱性和潜在的神经发生再生在疾病中的作用
Gregory W Kirschen,Rachel Kéry,Shaoyu Ge
Gregory W Kirschen
Brain metabolism is a fragile balance between nutrient/oxygen supply provided by the blood and neuronal/glial demand. Small perturbations in these parameters are necessary for proper homeostatic functioning and information processing, but c...