Mice Lacking Glypican 4 Display Juvenile Hyperactivity and Adult Social Interaction Deficits [0.03%]
缺少Glypican 4的小鼠表现出儿童期过度活跃和成人期社交障碍
Cari Dowling,Nicola J Allen
Cari Dowling
Glypican 4 (Gpc4) is a heparan sulfate proteoglycan that regulates glutamatergic synapse formation and function in the developing brain. Gpc4 KO mice have been shown to have decreased excitatory synapse number and less synaptic GluA1 AMPA r...
Effects of Voluntary Exercise on Cell Proliferation and Neurogenesis in the Dentate Gyrus of Adult FMR1 Knockout Mice [0.03%]
自愿运动对成年FMR1基因敲除小鼠齿状回神经增生的影响
Cristina Pinar,Suk-Yu Yau,Zoe Sharp et al.
Cristina Pinar et al.
Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability that can be traced to a single gene mutation. This disorder is caused by the hypermethylation of the Fmr1 gene, which impairs translation of Fragile X Me...
Youngshik Choe,Samuel J Pleasure
Youngshik Choe
Neuronal connectivity in the cortex is determined by the laminar positioning of neurons. An important determinant of laminar positioning is likely to be the control of leading process behavior during migration, maintaining their tips direct...
Pathogenic Feed-Forward Mechanisms in Alzheimer's and Parkinson's Disease Converge on GSK-3 [0.03%]
阿尔茨海默病和帕金森病的致病正反馈机制均作用于GSK-3
Abdalla M Albeely,Scott D Ryan,Melissa L Perreault
Abdalla M Albeely
Alzheimer's disease (AD) and Parkinson's disease (PD) share many commonalities ranging from signaling deficits such as altered cholinergic activity, neurotrophin and insulin signaling to cell stress cascades that result in proteinopathy, mi...
Transgenic Mouse Models as Tools for Understanding How Increased Cognitive and Physical Stimulation Can Improve Cognition in Alzheimer's Disease [0.03%]
转基因小鼠模型作为研究增加认知和身体刺激如何改善阿尔茨海默病认知的工具
Amy Shepherd,Tracy D Zhang,Ariel M Zeleznikow-Johnston et al.
Amy Shepherd et al.
Cognitive decline appears as a core feature of dementia, of which the most prevalent form, Alzheimer's disease (AD) affects more than 45 million people worldwide. There is no cure, and therapeutic options remain limited. A number of modifia...
María Llorens-Martín
María Llorens-Martín
Alzheimer disease (AD) is the most common type of dementia in individuals over 65 years of age. The neuropathological hallmarks of the condition are Tau neurofibrillary tangles and Amyloid-β senile plaques. Moreover, certain susceptible re...
Physical Exercise Enhances Neuroplasticity and Delays Alzheimer's Disease [0.03%]
运动增强神经可塑性并延缓阿尔茨海默病的发展
Tzu-Wei Lin,Sheng-Feng Tsai,Yu-Min Kuo
Tzu-Wei Lin
Accumulating evidence indicates that exercise can improve learning and memory as well as attenuate neurodegeneration, including Alzheimer's disease (AD). In addition to improving neuroplasticity by altering the synaptic structure and functi...
Exercise-Induced Modulation of Neuroinflammation in Models of Alzheimer's Disease [0.03%]
运动诱导的阿尔茨海默病模型中的神经炎症调节作用
Áine M Kelly
Áine M Kelly
Alzheimer's disease (AD), a progressive, neurodegenerative condition characterised by accumulation of toxic βeta-amyloid (Aβ) plaques, is one of the leading causes of dementia globally. The cognitive impairment that is a hallmark of AD ma...
Exercise Improves Vascular Function, but does this Translate to the Brain? [0.03%]
运动改善血管功能，但这种功能会转化为脑功能的提升吗？
Jill N Barnes,Adam T Corkery
Jill N Barnes
The number of adults with Alzheimer's disease (AD) or related dementia is expected to increase exponentially. Interventions aimed to reduce the risk and progression of AD and dementia are critical to the prevention and treatment of this dev...
Cindy K Barha,Teresa Liu-Ambrose
Cindy K Barha
Engaging in targeted exercise interventions is a promising, non-pharmacological strategy to mitigate the deleterious effects of aging and disease on brain health. However, despite its therapeutic potential, a large amount of variation exist...