Identification and Characterisation of cis-Regulatory Elements Upstream of the Human Receptor Tyrosine Kinase Gene MERTK [0.03%]
人类受体酪氨酸激酶基因MERTK上游顺式调控元件的鉴定和特征分析
Alexander D Walsh,Laura J Johnson,Alexandra J Harvey et al.
Alexander D Walsh et al.
Background: MERTK encodes a receptor tyrosine kinase that regulates immune homeostasis via phagocytosis of apoptotic cells and cytokine-mediated immunosuppression. MERTK is highly expressed in the central nervous system (...
Taming the storm [0.03%]
驾驭风暴
Tal Burstyn-Cohen,Ning Quan
Tal Burstyn-Cohen
Low Molecular Weight (poly)Phenol Metabolites Across the Blood-Brain Barrier: The Underexplored Journey [0.03%]
低分子量茋类茋酚代谢物穿越血脑屏障：被忽视的旅程
Rafael Carecho,Diogo Carregosa,Cláudia Nunes Dos Santos
Rafael Carecho
The world of (poly)phenols arising from dietary sources has been significantly amplified with the discovery of low molecular weight (LMW) (poly)phenol metabolites resulting from phase I and phase II metabolism and microbiota transformations...
Flavonoids as an Intervention for Alzheimer's Disease: Progress and Hurdles Towards Defining a Mechanism of Action [0.03%]
黄酮类化合物治疗阿尔茨海默病的研究进展与挑战——作用机制的探索道路上不容忽视的问题
Katriona L Hole,Robert J Williams
Katriona L Hole
Attempts to develop a disease modifying intervention for Alzheimer's disease (AD) through targeting amyloid β (Aβ) have so far been unsuccessful. There is, therefore, a need for novel therapeutics against alternative targets coupled with ...
Preventing and Treating Neurological Disorders with the Flavonol Fisetin [0.03%]
黄酮醇山奈酚防治神经性疾病的功能与机制研究进展
Pamela Maher
Pamela Maher
Neurological disorders, including neurodegenerative diseases, have a significant negative impact on both patients and society at large. Since the prevalence of most of these disorders increases with age, the consequences for our aging popul...
Polyphenols and Cognition In Humans: An Overview of Current Evidence from Recent Systematic Reviews and Meta-Analyses [0.03%]
人类认知与多酚：近期系统评价和荟萃分析提供的证据概览
Daniel Joseph Lamport,Claire Michelle Williams
Daniel Joseph Lamport
Background: There is increasing interest in the impact of dietary influences on the brain throughout the lifespan, ranging from improving cognitive development in children through to attenuating ageing related cognitive d...
Catarina Rendeiro
Catarina Rendeiro
Effects of Ethanol on Synaptic Plasticity and NMDA Currents in the Juvenile Rat Dentate Gyrus [0.03%]
乙醇对幼年大鼠海马齿状回突触可塑性及N-甲基-D天冬氨酸受体介导电流的影响
Scott D Sawchuk,Hannah M O Reid,Katie J Neale et al.
Scott D Sawchuk et al.
Background and objectives: We examined how acute ethanol (EtOH) exposure affects long term depression (LTD) in the dentate gyrus (DG) of the hippocampus in juvenile rats. EtOH is thought to directly modulate n-methyl-D-as...
Acute Ethanol Exposure Enhances Synaptic Plasticity in the Dorsal Striatum in Adult Male and Female Rats [0.03%]
急性酒精暴露增强成人雄性和雌性大鼠背侧纹状体的突触可塑性
Yosef Avchalumov,Juan C Piña-Crespo,John J Woodward et al.
Yosef Avchalumov et al.
Background: Acute (ex vivo) and chronic (in vivo) alcohol exposure induces neuroplastic changes in the dorsal striatum, a critical region implicated in instrumental learning. ...
Yosef Avchalumov,Chitra D Mandyam
Yosef Avchalumov
Alcohol is one of the oldest pharmacological agents used for its sedative/hypnotic effects, and alcohol abuse and alcohol use disorder (AUD) continues to be major public health issue. AUD is strongly indicated to be a brain disorder, and th...