Locus-specific DNA methylation analysis of retrotransposons in ES, somatic and cancer cells using High-Throughput Targeted Repeat Element Bisulfite Sequencing [0.03%]
利用高通量靶向重复元件重亚硫酸氢盐测序分析ES、体细胞和癌细胞中内源逆转录子的特异性DNA甲基化模式
Arundhati Bakshi,Muhammad B Ekram,Joomyeong Kim
Arundhati Bakshi
DNA methylation is a major epigenetic mark associated with multiple aspects of retrotransposons within the mammalian genome. In order to study DNA methylation of a large number of retrotransposons on an individual-locus basis, we have devel...
Cell-type specific transcriptomic profiling to dissect mechanisms of differential dendritogenesis [0.03%]
细胞类型特异性转录谱分析解剖不同树突发生的机制
Surajit Bhattacharya,Eswar Prasad R Iyer,Srividya Chandramouli Iyer et al.
Surajit Bhattacharya et al.
The establishment, maintenance and modulation of cell-type specific neural architectures is critically important to the formation of functional neural networks. At the neuroanatomical level, differential patterns of dendritic arborization d...
Prognostic gene signature profiles of hepatitis C-related early-stage liver cirrhosis [0.03%]
与乙型肝炎和丙型肝炎相关的代偿期肝硬化的预后基因签名 profiling HEV- and HCV-related compensated livercirrhosis for prognosis
Anu Venkatesh,Xiaochen Sun,Yujin Hoshida
Anu Venkatesh
The rate of hepatitis C virus (HCV) related liver cirrhosis and subsequent cancer development is increasing and raising the risk of related mortality and morbidity. To address this issue, we aimed to develop a prognostic index that can be u...
Transcriptional profiling of MEF2-regulated genes in human neural progenitor cells derived from embryonic stem cells [0.03%]
胚胎干细胞来源的人神经干细胞中MEF2调节基因的转录谱分析
Shing Fai Chan,Xiayu Huang,Scott R McKercher et al.
Shing Fai Chan et al.
[Briefly describe the contents of the Data in Brief article. Tell the reader the repository and reference number for the data in the abstract to.] The myocyte enhancer factor 2 (MEF2) family of transcription factors is highly expressed in t...
Genome-wide redistribution of BRD4 binding sites in transformation resistant cells [0.03%]
转化抵抗细胞中BRD4结合位点的全基因重分布
Han Si,Paola Scaffidi,Anand Merchant et al.
Han Si et al.
Hutchinson-Gilford progeria syndrome (HGPS) patients do not develop cancer despite a significant accumulation of DNA damage in their cells. We have recently reported that HGPS cells are refractory to experimental oncogenic transformation an...
Development of novel filtering criteria to analyze RNA-sequencing data obtained from the murine ocular lens during embryogenesis [0.03%]
小鼠胚胎晶状体发育过程中RNA测序数据的新型过滤标准的建立分析
Abby L Manthey,Anne M Terrell,Salil A Lachke et al.
Abby L Manthey et al.
Next-generation sequencing of the transcriptome (RNA-Seq) is a powerful method that allows for the quantitative determination of absolute gene expression, and can be used to investigate how these levels change in response to an experimental...
Transcriptomic profiling of splenic B lymphomas spontaneously developed in B cell-specific TRAF3-deficient mice [0.03%]
B细胞特异性TRAF3缺陷小鼠自发产生的脾B淋巴瘤的转录组谱分析
Ping Xie,Carissa R Moore,Mavis R Swerdel et al.
Ping Xie et al.
TRAF3, a critical regulator of B cell survival, was recently recognized as a tumor suppressor gene in B lymphocytes. Specific deletion of TRAF3 from B lymphocytes leads to spontaneous development of marginal zone lymphomas (MZL) or B1 lymph...
Identifying direct targets of transcription factor Rfx2 that coordinate ciliogenesis and cell movement [0.03%]
识别调节因子Rfx2的直接靶点以协调纤毛发生和细胞运动
Taejoon Kwon,Mei-I Chung,Rakhi Gupta et al.
Taejoon Kwon et al.
Recently, using the frog Xenopus laevis as a model system, we showed that transcription factor Rfx2 coordinates many genes involved in ciliogenesis and cell movement in multiciliated cells (Chung et al., 2014). To our knowledge, it was the ...
Identification of Biomarkers in Breast Cancer by Gene Expression Profiling Using Human Tissues [0.03%]
基于人体组织的基因表达谱鉴定乳腺癌生物标志物
Junjie Fu,William Allen,Amy Xia et al.
Junjie Fu et al.
Breast cancer is the second leading cause of death by cancer in women. To identify biomarkers with potential diagnostic and therapeutic utilities in breast cancer, gene expression profiling from real patient tissues were used to discover si...
Genome sequencing and annotation of Afipia septicemium strain OHSU_II [0.03%]
阿菲皮亚菌(OHSU-II株)基因组测序与注释
Philip Yang,Guo-Chiuan Hung,Haiyan Lei et al.
Philip Yang et al.
We report the 5.1 Mb noncontiguous draft genome of Afipia septicemium strain OHSU_II, isolated from blood of a female patient. The genome consists of 5,087,893 bp circular chromosome with no identifiable autonomous plasmid with a G + C cont...