RNA-Seq analysis and whole genome DNA-binding profile of the Vibrio cholerae histone-like nucleoid structuring protein (H-NS) [0.03%]
霍乱弧菌组蛋白样染色体结构蛋白(H-NS)的RNA测序分析及全基因组DNA结合谱系
Julio C Ayala,Hongxia Wang,Jorge A Benitez et al.
Julio C Ayala et al.
The data described in this article pertain to the genome-wide transcription profiling of a Vibrio cholerae mutant lacking the histone-like nucleoid structuring protein (H-NS) and the mapping of the H-NS chromosome binding sites [1, 2]. H-NS...
Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap [0.03%]
转录因子TCF21通过调节平滑肌前体细胞参与纤维帽的形成来影响冠状动脉疾病发病机制
S T Nurnberg,K Cheng,A Raiesdana et al.
S T Nurnberg et al.
TCF21 is a basic helix-loop-helix transcription factor that has recently been implicated as contributing to susceptibility to coronary heart disease based on genome wide association studies. In order to identify transcriptionally regulated ...
Gene expression profiling reveals a possible role for somatostatin in the innate immune response of the liver [0.03%]
基因表达谱分析揭示了生长抑素在肝脏固有免疫反应中可能的作用
Jessica M Adams,Malcolm J Low
Jessica M Adams
Somatostatin is a neuropeptide hormone that inhibits pituitary growth hormone (GH) release. Using microarray analysis of gene expression in the livers of wildtype control and somatostatin knockout mice, we have previously identified a panel...
Transcriptional profiling of Foxo3a and Fancd2 regulated genes in mouse hematopoietic stem cells [0.03%]
小鼠造血干细胞中Foxo3a和Fancd2调节基因的转录谱分析
Xiaoli Li,Tingting Zhang,Andrew Wilson et al.
Xiaoli Li et al.
Functional maintenance of hematopoietic stem cells (HSCs) is constantly challenged by stresses like DNA damage and oxidative stress. Foxo factors, particularly Foxo3a, function to regulate the self-renewal of HSCs and contribute to the main...
Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases [0.03%]
联合GWAS分析：通过比较不同基因组分辨率下的类似GWAS识别与六种复杂疾病相关的新型通路关联
Michael J McGeachie,George L Clemmer,Jessica Lasky-Su et al.
Michael J McGeachie et al.
We show here that combining two existing genome wide association studies (GWAS) yields additional biologically relevant information, beyond that obtained by either GWAS separately. We propose Joint GWAS Analysis, a method that compares a pa...
Transcriptional profiling of SNAI2 regulated genes in primary human keratinocytes [0.03%]
SNAI2调节的主要人角质形成细胞基因转录谱分析
Devendra S Mistry,Yifang Chen,Ying Wang et al.
Devendra S Mistry et al.
Epithelial to mesenchymal transition transcription factors (EMT-TFs) such as SNAI2 have been found to be expressed endogenously in epidermal stem and progenitor cells and downregulated upon differentiation. The presence of SNAI2 in progenit...
Dynamics of GATA1 binding and expression response in a GATA1-induced erythroid differentiation system [0.03%]
GATA1诱导的红系分化系统中GATA1结合及表达反应的动力学特征
Deepti Jain,Tejaswini Mishra,Belinda M Giardine et al.
Deepti Jain et al.
During the maturation phase of mammalian erythroid differentiation, highly proliferative cells committed to the erythroid lineage undergo dramatic changes in morphology and function to produce circulating, enucleated erythrocytes. These cha...
Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer [0.03%]
基因组分析定义了口腔癌小鼠模型中侵袭性的分子基础
Varun Chalivendra,Krishna Latha Kanchi,Michael D Onken et al.
Varun Chalivendra et al.
To investigate the molecular basis underlying aggressive behavior in oral squamous cell carcinoma (OSCC), our laboratory developed a carcinogen-induced mouse oral cancer (MOC) cell line model that encompasses the growth and metastasis spect...
Discovery of Gene Regulation Pattern in Lung Cancer by Gene Expression Profiling Using Human Tissues [0.03%]
利用人类组织的基因表达谱研究肺癌中的基因调控模式
Junjie Fu,Ravil Khaybullin,Xiao Liang et al.
Junjie Fu et al.
Lung cancer continues to be one the most prevalent and life threatening cancers worldwide. In order to study the gene regulation pattern in lung cancer for new therapeutics discovery, gene expression profiling using human lung cancer tissue...
Multi-platform Genome-wide Analysis of Melanoma Progression to Brain Metastasis [0.03%]
多平台分析黑色素瘤向脑转移演进的机制研究
Diego M Marzese,Jamie L Huynh,Neal P Kawas et al.
Diego M Marzese et al.
Melanoma has a high tendency to metastasize to brain tissue. The understanding about the molecular alterations of early-stage melanoma progression to brain metastasis (MBM) is very limited. Identifying MBM-specific genomic and epigenomic al...