Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells [0.03%]
基因表达谱分析鉴别出神经胶质瘤干细胞和间叶胶质瘤干细胞的区别
Uma R Chandran,Soumya Luthra,Lucas Santana-Santos et al.
Uma R Chandran et al.
Tumor heterogeneity of high-grade glioma (HGG) is recognized by four clinically relevant subtypes based on core gene signatures. However, molecular signaling in glioma stem cells (GSCs) in individual HGG subtypes is poorly characterized. Pr...
Microarray analysis of the in vivo response of microglia to Aβ peptides in mice with conditional deletion of the prostaglandin EP2 receptor [0.03%]
在EP2受体条件性敲除小鼠中对Aβ肽体内反应的微胶质细胞微阵列分析
Jenny U Johansson,Nathaniel S Woodling,Holden D Brown et al.
Jenny U Johansson et al.
Amyloid-β (Aβ) peptides accumulate in the brains of patients with Alzheimer's disease (AD), where they generate a persistent inflammatory response from microglia, the innate immune cells of the brain. The immune modulatory cyclooxygenase/...
Xiangqian Guo,Erna Forgó,Matt van de Rijn
Xiangqian Guo
Leiomyosarcoma (LMS) is a malignant neoplasm with smooth muscle differentiation. Little is known about its molecular heterogeneity and no targeted therapy currently exists for LMS. We performed expression profiling on 99 cases of LMS with 3...
Analysis of paired end Pol II ChIP-seq and short capped RNA-seq in MCF-7 cells [0.03%]
MCF-7细胞Pol II ChIP-seq和短 capped RNA-seq的分析研究
Adam Scheidegger,Adam Burkholder,Ata Abbas et al.
Adam Scheidegger et al.
While a role of promoter-proximal RNA Polymerase II (Pol II) pausing in regulation of eukaryotic gene expression is implied, the mechanisms and dynamics of this process are poorly understood. We performed genome-wide analysis of short cappe...
Microarray gene expression profiling reveals potential mechanisms of tumor suppression by the class I HDAC-selective benzoylhydrazide inhibitors [0.03%]
微阵列基因表达谱分析揭示了一类I型组蛋白去乙酰酶选择性苯甲酰基肼抑制剂的抑瘤机制
Iqbal Mahmud,Daiqing Liao
Iqbal Mahmud
Histone deacetylase (HDAC) inhibitors (HDIs) have therapeutic potentials for treating cancer and other diseases. Modulation of gene expression by HDIs is a major mechanism underlying their therapeutic effects. A novel class of HDIs with a p...
An integrative approach to analyze microarray datasets for prioritization of genes relevant to lens biology and disease [0.03%]
整合分析微阵列数据集以优先处理与晶状体生物学和疾病相关的基因
Deepti Anand,Smriti Agrawal,Archana Siddam et al.
Deepti Anand et al.
Microarray-based profiling represents an effective method to analyze cellular or tissue-specific gene expression on the genome-level. However, in comparative analyses between control and mutant samples, microarrays often identify a large nu...
Annotation of suprachromosomal families reveals uncommon types of alpha satellite organization in pericentromeric regions of hg38 human genome assembly [0.03%]
染色体家族的注释揭示了人类基因组HG38组装中靠近着丝粒区域α卫星DNA的非常见类型
V A Shepelev,L I Uralsky,A A Alexandrov et al.
V A Shepelev et al.
Centromeric alpha satellite (AS) is composed of highly identical higher-order DNA repetitive sequences, which make the standard assembly process impossible. Because of this the AS repeats were severely underrepresented in previous versions ...
Transcriptome analysis of basal and luminal tumor-initiating cells in ErbB2-driven breast cancer [0.03%]
erbB2驱动的乳腺癌基底和管腔肿瘤起始细胞转录组分析
Nicholas Borcherding,Nicholas Bormann,David Kusner et al.
Nicholas Borcherding et al.
Breast cancer is the leading cause of cancer-related mortality for females worldwide.1 Improving early screening strategies and understanding the events that lead to tumor initiation have led to demonstrable improvements in clinical outcome...
Global Gene Expression Changes in Liver Following Hepatocyte Nuclear Factor 4 alpha deletion in Adult Mice [0.03%]
肝细胞核因子4α基因缺失后小鼠肝脏中的全基因表达变化
Sumedha Gunewardena,Chad Walesky,Udayan Apte
Sumedha Gunewardena
Hepatocyte nuclear factor 4 alpha (HNF4α) is known as the master regulator of hepatic differentiation, which regulates over 60% of the hepatocyte specific genes. Recent studies including this (Walesky et al. Am J Physiol Gastrointest Liver...
Gene expression profiles of Bapx1 expressing FACS sorted cells from wildtype and Bapx1-EGFP null mouse embryos [0.03%]
Bapx1表达的野生型和Bapx1-Egfp敲除小鼠胚胎FACS分选细胞的基因表达谱分析
Sumantra Chatterjee,V Sivakamasundari,Petra Kraus et al.
Sumantra Chatterjee et al.
The data described in this article refers to Chatterjee et al. (2015) "In vivo genome-wide analysis of multiple tissues identifies gene regulatory networks, novel functions and downstream regulatory genes for Bapx1 and its co-regulation wit...