Transcriptome profiling of sleeping, waking, and sleep deprived adult heterozygous Aldh1L1 - eGFP-L10a mice [0.03%]
用于转录组分析的成年Aldh1L1单杂合小鼠品系Aldh1L1+/-;eGFP-L10a及其背景BALB/cAnNCrl的描述：睡眠，觉醒和睡眠剥夺状况下的基因表达谱分析
Michele Bellesi,Luisa de Vivo,Giulio Tononi et al.
Michele Bellesi et al.
Transcriptomic studies revealed that hundreds of mRNAs show differential expression in the brains of sleeping relative to awake rats, mice, flies, and sparrows. Although these results have offered clues regarding the molecular consequences ...
Molecular profiling of MPS1 gene silencing in U251 glioma cell line [0.03%]
U251胶质瘤细胞系中MPS1基因沉默的分子谱分析
Uma Shankavaram,Uday Bhanu Maachani,Shuping Zhao et al.
Uma Shankavaram et al.
Aneuploidy has been recognized as a common characteristic of cancers. Aneuploidy frequently results from errors of the mitotic checkpoint, the major cell cycle control mechanism that acts to prevent chromosome missegregation. Mutation of th...
Identification of transcripts regulated by CUG-BP, Elav-like family member 1 (CELF1) in primary embryonic cardiomyocytes by RNA-seq [0.03%]
RNA测序鉴定主要胚胎心肌细胞中由CUG-BP，Elavl家族成员1（CELF1）调节的转录本
Yotam Blech-Hermoni,Andrea N Ladd
Yotam Blech-Hermoni
CUG-BP, Elav-like family member 1 (CELF1) is a multi-functional RNA binding protein that regulates pre-mRNA alternative splicing in the nucleus, as well as polyadenylation status, mRNA stability, and translation in the cytoplasm [1]. Dysreg...
Analysis of transcript changes in a heme-deficient mutant of Escherichia coli in response to CORM-3 [Ru(CO)3Cl(glycinate)] [0.03%]
关于E.coli血红素缺乏突变体响应CORM-3[Ru(CO)3Cl(甘氨酸)]的转录变化分析
Jayne Louise Wilson,Samantha McLean,Ronald Begg et al.
Jayne Louise Wilson et al.
This article describes in extended detail the methodology applied for acquisition of transcriptomic data, and subsequent statistical data modelling, published by Wilson et al. (2015) in a study of the effects of carbon monoxide-releasing mo...
Ryan Y Wong,John Godwin
Ryan Y Wong
Behavioral displays or physiological responses are often influenced by intrinsic and extrinsic mechanisms in the context of the organism's evolutionary history. Understanding differences in transcriptome profiles can give insight into adapt...
Epigenetic Regulation of Apoptosis and Cell Cycle Regulatory Genes in Human Colon Carcinoma Cells [0.03%]
人类结肠癌细胞中调控凋亡及细胞周期基因的表观遗传机制研究
Amy V Paschall,Kebin Liu
Amy V Paschall
5-Fluorouracil (5-FU) is the standard chemotherapy for certain high risk stage 2 and all stages 3 and 4 human colorectal cancer patients. However, patients often develop chemoresistance to 5-FU. We have identified verticillin A from Vertici...
Prenatal Exposure to Cadmium and Cotinine and CpG island DNA methylation in Mother-Infant Pairs [0.03%]
孕期接触镉和可替宁与母胎DNA Cp岛甲基化的关系研究
Saideep Gona,Alison P Sanders,Marie Lynn Miranda et al.
Saideep Gona et al.
A precise biological mechanism by which cadmium acts as a developmental toxicant is unknown but is suggested to include an epigenetic basis. In prior work, we analyzed CpG island methylation levels within gene promoters (n=16,421) in leukoc...
Transcriptional Profiling of Mycobacterium tuberculosis Replicating in the Human Type II Alveolar Epithelial Cell Line, A549 [0.03%]
鸟型结核分枝杆菌在人II型肺泡上皮细胞系A549内复制的转录分析
Michelle B Ryndak,Krishna K Singh,Zhengyu Peng et al.
Michelle B Ryndak et al.
Alveolar epithelial cells outnumber alveolar macrophages by ~500 fold and increasing evidence suggests Mycobacterium tuberculosis may replicate dramatically in these cells during the initial weeks of infecting the lung [1,2]. Here, we repor...
Platform comparison of detecting copy number variants with microarrays and whole-exome sequencing [0.03%]
基于微阵列和外显子组测序检测拷贝数变异的平台比较分析
Joep de Ligt,Philip M Boone,Rolph Pfundt et al.
Joep de Ligt et al.
Copy number variation (CNV) is a common source of genetic variation that has been implicated in many genomic disorders, Mendelian diseases, and common/complex traits. Genomic microarrays are often employed for CNV detection. More recently, ...
Eric J Belfield,Carly Brown,Xiangchao Gan et al.
Eric J Belfield et al.
We performed array comparative genome hybridization (aCGH) analyses of five Arabidopsis thaliana mutants with genomic deletions ranging in size from 4 bp to > 5 kb. We used the Roche NimbleGen Arabidopsis CGH 3 × 720 K whole genome custom ...