Genome-wide binding of transcription factors in inv(16) acute myeloid leukemia [0.03%]
16号染色体臂间倒位的急性髓系白血病中转录因子结合基因组的研究
A Mandoli,K Prange,J H A Martens
A Mandoli
The inv(16) translocation is associated with 5% of AML cases and gives rise to expression of the oncofusion protein CBFβ-MYH11. Although different molecular mechanisms for the oncogenic activity of this fusion protein have been proposed th...
GeoChip profiling of microbial community in response to global changes simulated by soil transplant and cropping [0.03%]
土壤移植和轮作对全球变化下微生物功能的影响：基于GeoChip的分析
Mengxin Zhao,Feng Wang,Shanshan Liu et al.
Mengxin Zhao et al.
Microbe plays an important role in driving biogeochemical cycles, thus it is of great interest to understand microbial responses and feedbacks to global changes. We have recently analyzed functional potentials of soil microbial community vi...
Genome-wide copy number profiling to detect gene amplifications in neural progenitor cells [0.03%]
全基因组拷贝数谱分析鉴定神经前体细胞中的基因扩增现象
U Fischer,A Keller,C Backes et al.
U Fischer et al.
DNA sequence amplification occurs at defined stages during normal development in amphibians and flies and seems to be restricted in humans to drug-resistant and tumor cells only. We used array-CGH to discover copy number changes including g...
Genome-wide analysis of high risk human papillomavirus E2 proteins in human primary keratinocytes [0.03%]
人乳头瘤病毒E2蛋白在人体主要角质细胞的全基因组分析
Nuchsupha Sunthamala,Chai Ling Pang,Francoise Thierry et al.
Nuchsupha Sunthamala et al.
The E2 protein is expressed in the early stage of human papillomavirus (HPV) infection that is associated with cervical lesions. This protein plays important roles in regulation of viral replication and transcription. To characterize the ro...
Transcriptome profiling for discovery of genes involved in shoot apical meristem and flower development [0.03%]
与芽顶端分生组织和花发育有关的基因转录图谱分析研究
Vikash K Singh,Mukesh Jain
Vikash K Singh
Flower development is one of the major developmental processes that governs seed setting in angiosperms. However, little is known about the molecular mechanisms underlying flower development in legumes. Employing RNA-seq for various stages ...
GeoChip as a metagenomics tool to analyze the microbial gene diversity along an elevation gradient [0.03%]
基于GeoChip的宏基因组分析不同海拔土壤微生物功能基因多样性分布及其环境影响因素
Ying Gao,Shiping Wang,Depeng Xu et al.
Ying Gao et al.
To examine microbial responses to climate change, we used a microarray-based metagenomics tool named GeoChip 4.0 to profile soil microbial functional genes along four sites/elevations of a Tibetan mountainous grassland. We found that microb...
Gene expression analysis of livers from female B6C3F1 mice exposed to carcinogenic and non-carcinogenic doses of furan, with or without bromodeoxyuridine (BrdU) treatment [0.03%]
不同剂量富喃致B6C3F1雌性小鼠肝毒性和致癌性的基因表达分析及溴脱氧尿苷处理的影响
Anna Francina Webster,Andrew Williams,Leslie Recio et al.
Anna Francina Webster et al.
Standard methodology for identifying chemical carcinogens is both time-consuming and resource intensive. Researchers are actively investigating how new technologies can be used to identify chemical carcinogens in a more rapid and cost-effec...
cFLIP expression is altered in severe corticosteroid-resistant asthma [0.03%]
重度皮质类固醇抵抗型哮喘患者cFLIP表达异常
Dennis Lazarev,Rachel L Miller,Emily Dimango et al.
Dennis Lazarev et al.
Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human diseases. In this study we carried out the first systematic search for asthma-associated changes in alternative splicing events, using a model...
Transcriptional dysregulation of the multifunctional zinc finger factor 423 in acute lymphoblastic leukemia of childhood [0.03%]
儿童急性淋巴细胞白血病中多功能Cys2His2型锌指因子423的转录失调
Lena Harder,Benjamin Otto,Martin A Horstmann
Lena Harder
Differentiation arrest is a hallmark of acute lymphoblastic leukemia (ALL). Among a variety of structural and chromosomal alterations, especially mutations in genes encoding for regulators of B cell differentiation are common. The objective...
Using SNP array to identify aneuploidy and segmental imbalance in translocation carriers [0.03%]
应用SNP阵列检测易位携带者的非整倍体和片段不平衡
B Xiong,K Tan,Y Q Tan et al.
B Xiong et al.
Translocation is one of the more common structural rearrangements of chromosomes, with a prevalence of 0.2%. The two most common types of chromosomal translocations, Robertsonian and reciprocal, usually result in no obvious phenotypic abnor...