MEN1 and pituitary adenomas [0.03%]
MEN1与垂体腺瘤
Brigitte Delemer
Brigitte Delemer
MEN1 gene mutations predispose carriers to pituitary tumors. Molecular pathways involved in the development of these tumors seem different to what is known in sporadic tumors. Clinical studies showed that all types of adenomas can be found ...
Natalia S Pellegata
Natalia S Pellegata
Multiple endocrine neoplasias (MEN) are a group of hereditary disorders characterized by tumors arising in more than one neuroendocrine tissue. There are two major forms which can occur in humans, MEN type 1 (MEN1) and MEN type 2 (MEN2). Th...
Treatment of nonfunctioning pituitary adenomas: what were the contributions of the last 10 years? A critical view [0.03%]
垂体非功能性腺瘤的治疗：过去十年的贡献何在？批判性回顾
Alberto M Pereira,Nienke R Biermasz
Alberto M Pereira
Objectives: All evidence for treatment and follow-up for nonfunctioning pituitary adenomas (NFMA) is based on observational studies. The objective was to critically review the contributions of the last 10 years on treatme...
Male acquired hypogonadotropic hypogonadism: diagnosis and treatment [0.03%]
男性获得性低促性腺激素性腺功能减退症的诊断与治疗
Sylvie Salenave,Sévérine Trabado,Luigi Maione et al.
Sylvie Salenave et al.
Acquired hypogonadotropic hypogonadism (AHH), contrary to congenital hypogonadotropic hypogonadism (CHH) is characterized by postnatal onset of disorders that damage or alter the function of gonadotropin-releasing hormone (GnRH) neurons and...
Marily Theodoropoulou
Marily Theodoropoulou
Diagnostic and therapeutic challenges of acquired thyrotropic deficiency [0.03%]
获得性甲状腺刺激功能减退的诊断和治疗挑战
Luca Persani,Marco Bonomi,Raffaella Radin et al.
Luca Persani et al.
The acquired thyrotropic deficiency (TD) is a hypothyroid condition due to an insufficient stimulation by thyrotropin (TSH) of an otherwise normal thyroid gland. This disease can be the consequence of disorders affecting either the pituitar...
The value of a European registry for pituitary adenomas: the example of Cushing's syndrome registry [0.03%]
垂体腺瘤欧洲登记处的价值：库欣综合征登记处的案例展示
Susan M Webb,Alicia Santos,Elena Valassi
Susan M Webb
In the field of Rare Diseases, patient registries and databases are key instruments for the development of clinical research, improvement of patient care and healthcare planning. They can achieve a sufficient sample size for epidemiological...
Autoimmune hypophysitis: autoantigens and association with CTLA-4 blockade [0.03%]
自身免疫性垂体炎：自身抗原与CTLA-4阻断的关系
Patrizio Caturegli
Patrizio Caturegli
Xavier Bertagna,Laurence Guignat
Xavier Bertagna
Transsphenoidal surgery, possibly through the endoscopic approach, remains the first line treatment. Opposing cortisol action with mifepristone proved efficacious in some individual cases but but with major monitoring difficulties. Combined...
Guy Decaux
Guy Decaux
The vaptans are non-peptide arginine-vasopressin-receptor antagonists, that are orally and intravenously active. A few vaptans have undergone sufficient clinical development to be on the market. In the EU only tolvaptan is accepted to treat...