Sébastien Czernichow,Claire Carette
Sébastien Czernichow
Obesity affects about 15 % of the French population, and is associated with numerous morbidities, including some cancers. In this context the diagnosis of cancer is a frequently more delayed, and with higher mortality. Methods of restrictiv...
[Can xenobiotics accumulated in adipose tissue contribute to a carcinogenic risk?] [0.03%]
[外源性物质能在脂肪组织蓄积并增加致癌风险吗?]
Robert Barouki
Robert Barouki
Some contaminants and environmental pollutants influence the development of the adipose tissue as well as its inflammatory state. In addition, persistent organic pollutants, which can be carcinogenic, are stored in this tissue. This leads t...
Camille Loubière,Béatrice Dirat,Jean-François Tanti et al.
Camille Loubière et al.
Cancer and type II diabetes are two diseases that appear to be associated. In fact, diabetes increases the incidence of several cancers (colon, endometrium, rectum and breast). Retrospective epidemiological studies show that metformin, a dr...
Lluis Fajas
Lluis Fajas
An important hallmark of cancer cells is a profound change in metabolism. Indeed, most tumor cells are characterized by higher rates of glycolysis, lactate production, and biosynthesis of lipids and other macromolecules. Our group, among ot...
Anne-Françoise Burnol,Lucille Morzyglod,Lucie Popineau
Anne-Françoise Burnol
Epidemiological studies provide evidence for a close relationship between diabetes and cancer. Insulin is in fact a growth factor, and its binding to its membrane receptor activates intracellular signaling pathways involved in the regulatio...
Benoit Viollet,Marc Foretz
Benoit Viollet
Although considerable efforts have been made since the 1950s to better understand the action of metformin, the first line therapeutic for type 2 diabetes, its mechanisms of action has not been fully elucidated. The main antidiabetic effect ...
Contribution of endothelial precursors of adipose tissue to breast cancer: progression-link with fat graft for reconstructive surgery [0.03%]
脂肪组织内皮前体细胞对乳腺癌的贡献及其与重建手术用脂肪移植的进展联系研究
Francesco Bertolini
Francesco Bertolini
Obesity, an excess accumulation of adipose tissue occurring in mammalians when caloric intake exceeds energy expenditure, is associated with an increased frequency and progression of several types of neoplastic diseases including postmenopa...
GLP-1 receptor agonists or DPP-4 inhibitors: how to guide the clinician? [0.03%]
GLP-1受体激动剂或DPP-4抑制剂：如何指导临床用药？
André J Scheen
André J Scheen
Pharmacological treatment of type 2 diabetes has been enriched during recent years, with the launch of incretin therapies targeting glucagon-like peptide-1 (GLP-1). Such medications comprise either GLP-1 receptor agonists, with short (one o...
Bruno Fève
Bruno Fève
Adipose tissue has long been considered as an « organ » of energy storage. Although many works had previously identified the secretory nature of adipocyte, it was only in 1994, when the leptin gene was cloned, that adipose tissue earned t...
The role of the mTOR pathway during liver regeneration and tumorigenesis [0.03%]
mTOR信号通路在肝脏再生及致瘤过程中的作用研究进展
Ganna Panasyuk,Cecilia Patitucci,Catherine Espeillac et al.
Ganna Panasyuk et al.
It is established that overnutrition is a risk factor for hepatocellular carcinoma. Il has been proposed that hepatic steatosis leads to a subinflammatory response and to the production of mitogenic cytokines. Our team is focused on the rol...