Virginie Rouiller-Fabre,René Habert,Gabriel Livera
Virginie Rouiller-Fabre
The modern societies are exposing us to a huge variety of potentially harmful pollutants. Among these endocrine disruptors (EDs) have been especially scrutinized as several were proven to display reprotoxic effects in rodent models. In the ...
Ellen Goossens,Herman Tournaye
Ellen Goossens
Male fertility preservation receives growing attention in the field of reproductive medicine. The first clinical programs were established to preserve reproductive potential in men needing gonadotoxic treatment. Sperm cryopreservation is no...
Rodolfo A Rey
Rodolfo A Rey
The ontogeny of the hypothalamic-pituitary-gonadal axis is particularly characterised by incomplete functional maturation in utero and during early postnatal life, followed by functional regression and partial quiescence during childhood, a...
Eberhard Nieschlag,Steffi Werler,Joachim Wistuba et al.
Eberhard Nieschlag et al.
The Klinefelter syndrome (KS), with an incidence of 1 to 2 per 1000 male neonates, is one of the most frequent congenital chromosome disorders. The 47,XXY karyotype causes infertility, testosterone deficiency and a spectrum of further sympt...
Ilpo T Huhtaniemi
Ilpo T Huhtaniemi
Andropause or late-onset hypogondism (LOH) is a situation where a middle-aged or older man has low serum testosterone (T) in conjunction with diffuse symptoms reminiscent of those of genuine male hypogonadism (e.g. reduced sexual function, ...
Christa E Flück,Amit V Pandey
Christa E Flück
Defects of androgen biosynthesis cause 46,XY disorder of sexual development (DSD). All steroids are produced from cholesterol and the early steps of steroidogenesis are common to mineralocorticoid, glucocorticoid and sex steroid production....
Yves Morel,Florence Roucher,Delphine Mallet et al.
Yves Morel et al.
Fetal sexual differentiation results from complex subsequent intracellular signaling and hormonal events that interact together in a definite timing. This process contributes to the setting of gonad determination, internal and external geni...
Ingrid Plotton,Aurélie Brosse,Beatrice Cuzin et al.
Ingrid Plotton et al.
Until few years ago, Klinefelter syndrome with a homogenous 47,XXY karyotype was considered a model of absolute male sterility. We will discuss first the potential fertility following Testicular Sperm Injection, then the physiopathology of ...
Jorma Toppari,Wiwat Rodprasert,Helena E Virtanen
Jorma Toppari
Testes descend to the scrotum normally before birth. When they fail to do so, the boy is cryptorchid and has an increased risk for testicular germ cell cancer and subfertility later in life. Early correction of maldescent by orchiopexy oper...
Martine Cools
Martine Cools
The risk of germ cell cancer is elevated in many DSD patients, although not to the same extent. A number of risk factors have been identified recently, but their interplay and relative impact is currently not fully clear. Until the advent o...