Anne Thomin,Stéphanie Friszer,Anne Fajac et al.
Anne Thomin et al.
Breast cancer prevention can be provided by using SERMs or aromatase inhibitors depending on the ovarian status, with a global risk reduction of 50 to 60%. Prophylactic annexectomy offered to reduce ovarian risk in BRCA mutation carriers al...
Randomized Controlled Trial
Annales d'endocrinologie. 2014 Jul;75(3):148-55. DOI:10.1016/j.ando.2014.04.012 2014
p.Ala541Thr variant of MEN1 gene: a non deleterious polymorphism or a pathogenic mutation? [0.03%]
MEN1基因的p.Ala541Thr变异：无害多态性还是致病突变？
Cecile Nozières,Chang-Xian Zhang,Alexandre Buffet et al.
Cecile Nozières et al.
Context: Multiple Endocrine Neoplasia Type 1 (MEN1) is an autosomal dominant inherited syndrome, related to mutations in the MEN1 gene. Controversial data suggest that the nonsynonymous p.Ala541Thr variant, usually consid...
Changes of serum omentin-1 levels in normal subjects, type 2 diabetes and type 2 diabetes with overweight and obesity in Chinese adults [0.03%]
中国人成年人正常人群、2型糖尿病及2型肥胖糖尿病患者网膜素-1水平变化研究
Qiang Zhang,Lei Zhu,Min Zheng et al.
Qiang Zhang et al.
Purpose: Omentin-1 has been identified as interesting novel adipokines that may modulate insulin action. Its exact biological function is unclear. The aim of this study is to assay the levels of serum omentin-1 in normal ...
A monocentric experience of growth hormone replacement therapy in adult patients [0.03%]
成人患者生长激素替代治疗的单中心经验报告
Lyès Abdi,Mona Sahnoun-Fathallah,Isabelle Morange et al.
Lyès Abdi et al.
Objectives: To describe the results of growth hormone (GH) therapy in adult GH-deficient patients treated in a tertiary referral center, with a focus on quality of life and adherence. ...
Evaluation of circulating irisin levels in healthy young individuals after a single 100,000 IU vitamin D dose [0.03%]
评估健康年轻人单次大剂量维生素D补充对循环肌肉源性因子irisin水平的影响
Étienne Cavalier,Valentine Mismetti,Jean-Claude Souberbielle
Étienne Cavalier
Irisin is a newly discovered hormone produced by the muscle. This hormone is involved in glucose metabolism, muscle strength and energy expenditure. As vitamin D is also known as a key player in that field, we aimed to see if a single dose ...
Pyramidal lobe decreases endogenous TSH stimulation without impact on radio-iodine therapy outcome in patients with differentiated thyroid cancer [0.03%]
锥状叶减少分化型甲状腺癌患者的内源性TSH刺激而不影响放射碘治疗效果
Nadia Sawicka-Gutaj,Aleksandra Klimowicz,Jerzy Sowinski et al.
Nadia Sawicka-Gutaj et al.
Objectives: The aim of the study was to assess the frequency of pyramidal lobe (PL) detected in iodine-131 (I-131) scans of thyroid bed in patients after thyroidectomy for differentiated thyroid cancer (DTC) and to invest...
The testis through the ages [0.03%]
睾丸的历叐变迁
Jacques Young
Jacques Young
Congenital hypogonadotropic hypogonadism and Kallmann syndrome as models for studying hormonal regulation of human testicular endocrine functions [0.03%]
先天性低促性腺素性性腺功能减退症和卡尔曼综合征作为研究激素调节人类睾丸内分泌功能模型的认识
Séverine Trabado,Sophie Lamothe,Luigi Maione et al.
Séverine Trabado et al.
Men with Kallmann syndrome (KS) and those with congenital isolated hypogonadotropic hypogonadism with normal olfaction share a chronic, usually profound deficit, in FSH and LH, the two pituitary gonadotropins. Many studies indicate that thi...
Disrupting the male germ line to find infertility and contraception targets [0.03%]
扰乱雄性生殖系以寻找不孕和避孕靶点
Denise R Archambeault,Martin M Matzuk
Denise R Archambeault
Genetically-manipulated mouse models have become indispensible for broadening our understanding of genes and pathways related to male germ cell development. Until suitable in vitro systems for studying spermatogenesis are perfected, in vivo...
Hormonal control of spermatogenesis in men: therapeutic aspects in hypogonadotropic hypogonadism [0.03%]
男性精子发生的激素调控在继发性性腺功能减退的治疗中的作用
Nelly Pitteloud,Andrew Dwyer
Nelly Pitteloud
During the first two trimesters of intrauterine life, fetal sex steroid production is driven by maternal human chorionic gonadotropin (hCG). The HPG axis is activated around the third trimester and remains active for the first 6-months of n...