Chromothripsis in a Case of TP53-Deficient Chronic Lymphocytic Leukemia [0.03%]
TP53缺陷型慢性淋巴细胞白血病的染色体碎裂综合征
Jianming Pei,Suresh C Jhanwar,Joseph R Testa
Jianming Pei
We describe genomic findings in a case of CLL with del(17p13.1) by FISH, in which SNP array analysis revealed chromothripsis, a phenomenon by which regions of the cancer genome are shattered and recombined to generate frequent oscillations ...