Gelatinous transformation of bone marrow following the use of dasatinib in a patient with philadelphia chromosome-positive acute lymphoblastic leukemia [0.03%]
达沙替尼治疗费城染色体阳性急性淋巴细胞白血病后骨髓角化异常转变的一例报告
Sanjeev Kumar Sharma,Dharma Choudhary,Anil Handoo et al.
Sanjeev Kumar Sharma et al.
Hemophagocytic lymphohistiocytosis masquerading as progressive chronic lymphocytic leukemia [0.03%]
以进行性慢性淋巴细胞白血病形式表现的噬血细胞性淋巴组织细胞增生症
Deepak Kilari,Nicholas Venci,Jonathan Friedberg et al.
Deepak Kilari et al.
Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal syndrome characterized by a non-malignant expansion of the macrophage population in the setting of a heightened cytokine response with subsequent widespread hemophagocytosis. I...
Somatic mutations of the CREBBP and EP300 genes affect response to histone deacetylase inhibition in malignant DLBCL clones [0.03%]
CREBBP和EP300基因的体细胞性突变影响组蛋白脱乙酰酶抑制剂在恶性DLBCL克隆中的作用响应
Christen Lykkegaard Andersen,Fazila Asmar,Tobias Klausen et al.
Christen Lykkegaard Andersen et al.
Heterogeneous clinical responses to histone deacetylase inhibitors (HDACi) in diffuse large B-cell lymphoma (DLBCL) have prompted a need for evaluating the impact of mutations in the histone acetyl transferases (HAT) CREBBP and EP300 on HDA...
Suneel Mundle,Meir Wetzler
Suneel Mundle
Complex hypereosinophilia arising from post-polycythemia vera myelofibrosis: A case of imatinib-responsiveness [0.03%]
真性红细胞增多症后骨髓纤维化继发的复杂高嗜酸粒细胞综合征一例及伊马替尼治疗反应分析
Ryan D Gentzler,Alex C Minella,Brady L Stein
Ryan D Gentzler
The classical myeloproliferative neoplasms (MPNs) feature an overproduction of mature blood elements. Phenotypic conversion, including transformation to myelofibrosis (MF) in those with antecedent ET and PV is a feared complication. Hypereo...
New diagnosis of multiple myeloma in a patient with mantle cell lymphoma: Shared genetic factors or simple coincidence? [0.03%]
mantle细胞淋巴瘤患者新诊断多发性骨髓瘤：共享的遗传因素还是简单的巧合？
Mutende J Sikuyayenga,Craig B Reeder,Joseph R Mikhael
Mutende J Sikuyayenga
Multiple Myeloma and Mantle Cell Lymphoma are well defined hematological malignancies. Understanding of their pathogeneses has led to new therapies and increased survival. We report on a 64-yr-old female who was diagnosed with mantle cell l...
Bilateral renal artery stenosis in a patient with chronic myeloid leukemia treated with nilotinib [0.03%]
尼洛替尼治疗的慢性髓性白血病患者并发双侧肾动脉狭窄病例报告
Tilde Kristensen,Else Randers,Jesper Stentoft
Tilde Kristensen
Previously authors have recently described an association between nilotinib therapy for chronic myeloid leukemia (CML) and severe peripheral artery disease, coronary artery disease and sudden death. We present a case report of a male patien...
Strategies to circumvent the T315I gatekeeper mutation in the Bcr-Abl tyrosine kinase [0.03%]
绕过Bcr-Abl酪氨酸激酶T315I守门人突变的策略
Prithviraj Bose,Haeseong Park,Jawad Al-Khafaji et al.
Prithviraj Bose et al.
Despite the remarkable success of imatinib against Bcr-Abl, development of secondary resistance, most often due to point mutations in the Bcr-Abl tyrosine kinase (TK) domain, is quite common. Of these, the T315I "gatekeeper" mutation is res...
Mcl-1 as a Therapeutic Target in Acute Myelogenous Leukemia (AML) [0.03%]
凋亡调节蛋白Mcl-1作为急性髓系白血病治疗靶点的研究进展
Prithviraj Bose,Steven Grant
Prithviraj Bose
The B-cell lymphoma-2 (Bcl-2) family of proteins regulates the intrinsic, or mitochondrial pathway of apoptosis, the final common mechanism of cell death in response to a variety of physiologic and pharmacologic signals, and plays a central...