An exploratory phase 2 study of investigational Aurora A kinase inhibitor alisertib (MLN8237) in acute myelogenous leukemia and myelodysplastic syndromes [0.03%]
一项针对急性髓系白血病和骨髓增生异常综合征受试者的II期试验性阿尔西瑞布（MLN8237）研究
Stuart L Goldberg,Pierre Fenaux,Michael D Craig et al.
Stuart L Goldberg et al.
Alisertib (MLN8237) is an investigational, oral, selective, Aurora A kinase (AAK) inhibitor. In this phase 2 trial, 57 patients with acute myeloid leukemia (AML) or high-grade myelodysplastic syndrome received alisertib 50 mg BID for 7 days...
Identification of a novel SEPT9-ABL1 fusion gene in a patient with T-cell prolymphocytic leukemia [0.03%]
发现一个新颖的SEPT9-ABL1融合基因用于T细胞前体淋巴瘤患者
Rikio Suzuki,Hiromochi Matsushita,Hidetsugu Kawai et al.
Rikio Suzuki et al.
T-cell prolymphocytic leukemia (T-PLL), a rare type of peripheral T-cell leukemia, is characterized by marked splenomegaly with rapidly progressive lymphocytosis and a poor prognosis. Nine kinds of ABL1 chimeric genes have been identified i...
Early relapse of Burkitt lymphoma heralded by a bone marrow necrosis and numb chin syndrome successfully treated with allogeneic stem cell transplantation [0.03%]
骨髓坏死和麻木下巴综合征预示的伯基特淋巴瘤早期复发接受异基因干细胞移植成功治疗
Jan Cerny,Katherine Devitt,Hongbo Yu et al.
Jan Cerny et al.
The optimal salvage therapy for patients with relapsed Burkitt lymphoma is unknown. Bone marrow necrosis is an underreported (2 years after the transplant. To our knowledge, this is the longest reported survival of the two syndromes in the ...
Jacqueline T Brown,W Richard Burack,Michael W Becker et al.
Jacqueline T Brown et al.
Translocation (8;21) acute myeloid leukemia presenting as severe aplastic anemia [0.03%]
伴严重再生障碍性贫血的t（8；21）急性髓系白血病
Enkhtsetseg Purev,Bogdan Dumitriu,Christopher S Hourigan et al.
Enkhtsetseg Purev et al.
We report a case of t(8;21) acute myeloid leukemia presenting as severe aplastic anemia. While initial bone marrow biopsy lacked any cytogenetic abnormalities in 20 analyzed metaphases, repeat bone marrow biopsy eight days later demonstrate...
Hemophagocytic lymphohistiocytosis secondary to T-cell/histiocyte-rich large B-cell lymphoma [0.03%]
吞噬细胞淋巴组织细胞增生症伴T细胞/组织细胞丰富的大B细胞淋巴瘤二期病症
Katherine Devitt,Jan Cerny,Bradley Switzer et al.
Katherine Devitt et al.
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome characterized by dysregulation of the immune system. Impaired function of cytotoxic T cells and natural killer cells is often seen, and T-cell malignancies rep...
Fludarabine and cyclophosphamide provides a nonmyeloablative alternative conditioning regimen with low transplant-related mortality and control of high risk disease [0.03%]
氟达拉滨和环磷酰胺提供了一种非骨髓消融的替代预处理方案，具有较低的移植相关死亡率及较高的高危疾病控制率
Pamela Paplham,Theresa Hahn,Karen Dubel et al.
Pamela Paplham et al.
Non-myeloablative allogeneic transplant (NMAT) has a curative potential for patients who are not myeloablative allogeneic transplant (MAT) candidates. We report a phase II trial of a NMAT regimen with cyclophosphamide and fludarabine in 40 ...
Acute myeloid leukemia arising from a donor derived premalignant hematopoietic clone: A possible mechanism for the origin of leukemia in donor cells [0.03%]
供体衍生的前恶性造血克隆导致急性髓系白血病的发生：可能解释移植物细胞中白血病起源的机制
Mark A Dickson,Esperanza B Papadopoulos,Cyrus V Hedvat et al.
Mark A Dickson et al.
During recent years, it has become increasingly evident that donor leukemia following allogeneic transplant may be more common then realized in the past. We identified five cases of potential donor leukemia cases during past five years. The...
Melchior Lauten,Simon Vieth,Christopher Hart et al.
Melchior Lauten et al.
We report on an 8 year old boy with primary cardiac anaplastic large cell lymphoma (ALCL), in whom the diagnosis was challenging and who was treated with modified chemotherapy without radiation therapy according to the ALCL 99 study protoco...
Acute leukemia of ambiguous lineage with trisomy 4 as the sole cytogenetic abnormality: A case report and literature review [0.03%]
四体性4作为唯一细胞遗传学异常的谱系不明急性白血病一例及文献复习
S Moraveji,A Torabi,Z Nahleh et al.
S Moraveji et al.
We describe a patient with acute leukemia of ambiguous lineage who had trisomy 4 as the sole cytogenetic abnormality. Clinical, pathological, immunophenotypic and molecular features are presented and compared with the previous 4 published c...