A novel del(8)(q23.2q24.11) contributing to disease progression in a case of JAK2/TET2 double mutated chronic myelomonocytic leukemia [0.03%]
一项新的del(8)(q23.2q24.11)易位促使JAK2/TET2双突变慢性粒单细胞白血病进展的新机制
Marie Toft-Petersen,Eigil Kjeldsen,Line Nederby et al.
Marie Toft-Petersen et al.
We have identified a novel 7.7 Mb del(8)(q23.2q24.11) in a patient progressing to acute myeloid leukemia (AML) following a 12-year stable phase of chronic myelomonocytic leukemia (CMML). A surprisingly high JAK2+ allelic burden of 92% at th...
Successful HLA haploidentical myeloablative stem cell transplantation for aggressive hepatosplenic alpha/beta (αβ) T-cell lymphoma [0.03%]
单倍型相合造血干细胞移植治疗侵袭性肝脾T细胞淋巴瘤1例
Gioacchino Catania,Francesco Zallio,Federico Monaco et al.
Gioacchino Catania et al.
Hepatosplenic T cell lymphoma (HSTCL) is a type of hematologic neoplasia with a poor prognosis and a high frequency of refractoriness to conventional chemotherapy. The results obtained by high dose chemotherapy followed by autologous stem c...
Deletion and deletion/insertion mutations in the juxtamembrane domain of the FLT3 gene in adult acute myeloid leukemia [0.03%]
成人急性髓样白血病中FLT3基因近膜区的缺失和点突变
Kristin K Deeb,Matthew T Smonskey,HanChun DeFedericis et al.
Kristin K Deeb et al.
In contrast to FLT3 ITD mutations, in-frame deletions in the FLT3 gene have rarely been described in adult acute leukemia. We report two cases of AML with uncommon in-frame mutations in the juxtamembrane domain of the FLT3 gene: a 3-bp (c.1...
An unusual case of splenomegaly and increased lactate dehydrogenase heralding acute myeloid leukemia with eosinophilia and RUNX1-MECOM fusion transcripts [0.03%]
巨大脾脏和乳酸脱氢酶升高的罕见病例伴嗜酸性粒细胞急性髓系白血病及RUNX1-MECOM融合转录本
Fabio Forghieri,Sara Bigliardi,Monica Morselli et al.
Fabio Forghieri et al.
We report the first case of acute myeloid leukemia (AML) with RUNX1-MECOM fusion transcripts, showing marked eosinophilia. A 63-year old man admitted in August 2013, had previously been observed in April 2013, because of persisting homogene...
The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells [0.03%]
ABT-737通过模拟BH3有效杀死急性髓系白血病起始细胞
Denis V Baev,Janusz Krawczyk,Michael O׳Dwyer et al.
Denis V Baev et al.
The anti-apoptotic proteins Bcl-XL and Bcl-2 are abundantly expressed in hematopoietic stem cells and/or progenitor cells. Furthermore, leukemic cells expressing these proteins are enriched in minimal residual disease cell populations. This...
Interaction between IL-6 and TNF-α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (ASCT) [0.03%]
与接受自体干细胞移植患者的细菌血症相关的白细胞介素-6和肿瘤坏死因子-α基因型的相互作用
Fernanda M B Trigo,Marcelo R Luizon,Hélio S Dutra et al.
Fernanda M B Trigo et al.
Stem cell transplantation affects patient׳s vulnerability to infections due to immunological changes related to chemotherapy. Multiple myeloma is characterized by susceptibility to infections, and IL-6 and TNF-α increased levels affect im...
Combination therapy with interferon and JAK1-2 inhibitor is feasible: Proof of concept with rapid reduction in JAK2V617F-allele burden in polycythemia vera [0.03%]
干扰素联合JAK1-2抑制剂治疗是可行的：用于验证概念的原发性血小板增多症中JAK2V617F等位基因负荷迅速降低的病例报告
M E Bjørn,K de Stricker,L Kjær et al.
M E Bjørn et al.
We report a 55 year old woman with post-ET PV for 12 years, who experienced resolution of severe constitutional symptoms within 3 days, a marked reduction in splenomegaly and a rapid decline in the JAK2V617F allele burden during combination...
Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients [0.03%]
慢性淋巴细胞性白血病患者体内人源内源性逆转录病毒NP9基因过度表达
Sabrina Fischer,Natalia Echeverría,Gonzalo Moratorio et al.
Sabrina Fischer et al.
The human genome contains a large number of endogenous retroviruses (HERVs). Their reactivation has frequently been observed in patients with cancer. Considering their role in the carcinogenesis process, we aimed to study the possible relat...
Significant clinical response to JAK1/2 inhibition in a patient with CSF3R-T618I-positive atypical chronic myeloid leukemia [0.03%]
CSF3R-T618I阳性非典型慢性粒细胞白血病患者的JAK1/2抑制显著临床反应案例
Kim-Hien T Dao,Magdolna B Solti,Julia E Maxson et al.
Kim-Hien T Dao et al.
Mutations in CSF3R (colony-stimulating factor 3 receptor) are frequent oncogenic drivers in chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML). Here we describe a 75 year old man who was diagnosed with CSF3R-T6...
High pseudotumor cerebri incidence in tretinoin and arsenic treated acute promyelocytic leukemia and the role of topiramate after acetazolamide failure [0.03%]
全反式维甲酸和砷剂治疗的急性早幼粒细胞白血病患者假性脑瘤发病率高及乙酰唑胺失败后托吡酯的作用
Morgan B Smith,Elizabeth A Griffiths,James E Thompson et al.
Morgan B Smith et al.
Dual differentiation therapy with arsenic trioxide and tretinoin (all-trans-retinoic acid; ATRA) for the management of low and intermediate risk acute promyelocytic leukemia has recently been recommended by the National Comprehensive Cancer...