Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells [0.03%]
SUMO蛋白酶SENP5与AML细胞的中性粒细胞分化之间的关联
Elena A Federzoni,Severin Gloor,Jing Jin et al.
Elena A Federzoni et al.
In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared to healthy neutrophil sam...
Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype [0.03%]
具有固有47, XXY核型的急性髓系白血病患者
Marla M Jalbut,Aliyah R Sohani,Paola Dal Cin et al.
Marla M Jalbut et al.
Klinefelter syndrome (KS), a 47,XXY chromosomal abnormality, has been shown to be associated with a number of malignancies, but has not been linked to acute leukemias to date. We present a case of a 54-year-old male diagnosed with acute mye...
Two novel RUNX1 mutations in a patient with congenital thrombocytopenia that evolved into a high grade myelodysplastic syndrome [0.03%]
两个新的RUNX1突变导致先天性血小板减少症并恶化成高级骨髓异常综合征
Jessica M Schmit,Daniel J Turner,Robert A Hromas et al.
Jessica M Schmit et al.
Here we report two new RUNX1 mutations in one patient with congenital thrombocytopenia that transformed into a high grade myelodysplastic syndrome with myelomonocytic features. The first mutation was a nucleotide base substitution from guan...
Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient [0.03%]
急性白血病患者的急性阑尾炎及地西他滨在危重患者中的潜在作用
Deepti Warad,Mira A Kohorst,Sadaf Altaf et al.
Deepti Warad et al.
Acute appendicitis in children with acute leukemia is uncommon and often recognized late. Immunocompromised host state coupled with the importance of avoiding treatment delays makes management additionally challenging. Leukemic infiltration...
An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML [0.03%]
老年继发孤立型NPM1基因突变复发急性髓系白血病的强化治疗方案研究
Srivasavi Dukka,David T Bowen
Srivasavi Dukka
We present a short case series of elderly patients with NK-AML and isolated NPM1 mutation who were treated with intensive chemotherapy, achieving significant CRs multiple times on reinduction, even with a single course.We hope to highlight ...
Effects of 5-azacytidine on natural killer cell activating receptor expression in patients with refractory anemia with excess of blasts [0.03%]
5-氮杂胞苷诱导难治性贫血伴原始细胞过多患者NK细胞活化受体的表达效应研究
Régis T Costello,Amélie Leclercq,Thérèse Le Treut et al.
Régis T Costello et al.
Epigenetic drugs modify DNA methylation and are used in refractory anemia with excess of blasts (RAEB). These drugs may reactivate anti-oncogene expression and restore a normal phenotype instead of inducing antitumor toxicity, although they...
"Preleukemic or smoldering" chronic myelogenous leukemia (CML):BCR-ABL1 positive: A brief case report [0.03%]
“临床上无症状或称作“类白血病期”的慢性髓性白血病（CML）：BCR-ABL1阳性：一例简短病例报告
John M Bennett,Kevin G Dsouza,Mehul Patel et al.
John M Bennett et al.
Chronic myelogenous leukemia (CML), in the Chronic Phase (CP), is often suspected as a result of a complete blood count (CBC), which shows increased granulocytes, mostly mature including a peak in myelocytes, increased basophils, and rarely...
Yiyi Yan,Thomas L Olson,Susan B Nyland et al.
Yiyi Yan et al.
Large granular lymphocyte (LGL) leukemia is a chronic clonal lymphoproliferative disorder. Here, a T-LGL leukemia patient developed NK-LGL leukemia with residual leukemic T-LGL. TCRVβ usage and CDR3 sequence drifts were observed with disea...
Progressive transfusion and growth factor independence with adjuvant sertraline in low risk myelodysplastic syndrome treated with an erythropoiesis stimulating agent and granulocyte-colony stimulating factor [0.03%]
低危骨髓增生异常综合征患者在接受促红细胞生成素和粒细胞集落刺激因子治疗过程中联用左洛复后进展性输血及生长因子独立的研究
Kirtan Nautiyal,Rui Li,Sarvari Yellapragada et al.
Kirtan Nautiyal et al.
Refractoriness to growth factor therapy is commonly associated with inferior outcome in patients with low-risk myelodysplastic syndrome (LR-MDS) who require treatment for cytopenias. However, the mechanisms leading to refractoriness are unk...
Acute promyelocytic leukemia with JAK2 V617F and severe differentiation syndrome [0.03%]
伴有JAK2 V617F和严重分化综合征的急性早幼粒细胞白血病
Theodore P Braun,Julia E Maxson,Anupriya Agarwal et al.
Theodore P Braun et al.
Myeloproliferative neoplasms transformed into AML usually have a poor prognosis. We report a case of essential thrombocythemia with myelofibrosis that transformed into acute promyelocytic leukemia (APL) with both the t(15;17) translocation ...