The YPEL5-PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples [0.03%]
YPEL5-PPP1CB融合转录本在不同血液系统恶性肿瘤及正常样本中的检测
Karl Vandepoele,Jan Philippé,Barbara Denys
Karl Vandepoele
Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). ...
Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952 [0.03%]
叶酸和药物代谢途径的遗传多态性与儿童急性淋巴细胞CCG-1952诱导缓解后复发风险的关系研究
Marijana Vujkovic,Aaron Kershenbaum,Lisa Wray et al.
Marijana Vujkovic et al.
Genetic variation in drug detoxification pathways may influence outcomes in pediatric acute lymphoblastic leukemia (ALL). We evaluated relapse risk and 24 variants in 17 genes in 714 patients in CCG-1961. Three TPMT and 1 MTR variant were a...
Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations [0.03%]
老年多发性骨髓瘤患者一线治疗复发模式及预后的危险因素分析——一项倾向评分匹配研究
Aurelio Lopez,Maria-Victoria Mateos,Albert Oriol et al.
Aurelio Lopez et al.
We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggr...
Pharmacological targeting of PI3K isoforms as a therapeutic strategy in chronic lymphocytic leukaemia [0.03%]
PI3K等位基因在慢性淋巴细胞白血病治疗中的作用机制研究进展及对策
Matthew D Blunt,Andrew J Steele
Matthew D Blunt
PI3Kδ inhibitors such as idelalisib are providing improved therapeutic options for the treatment of chronic lymphocytic leukaemia (CLL). However under certain conditions, inhibition of a single PI3K isoform can be compensated by the other ...
A radiolabeled antibody targeting CD123(+) leukemia stem cells - initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML [0.03%]
针对CD123阳性白血病干细胞的放射性标记抗体-在人类AML原始细胞植入NOD/SCID小鼠中的初次放免治疗研究
Jeffrey V Leyton,Catherine Gao,Brent Williams et al.
Jeffrey V Leyton et al.
Radioimmunotherapy (RIT) with anti-CD123 monoclonal antibody CSL360 modified with nuclear translocation sequence (NLS) peptides and labeled with the Auger electron-emitter, (111)In ((111)In-NLS-CSL360) was studied in the prevalent NOD/SCID ...
Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis [0.03%]
慢性期慢性粒细胞白血病的诊治并非总能令人安心
Ester M Orlandi,Chiara Elena,Silvia Zibellini
Ester M Orlandi
Primary resistance to tyrosine-kinase inhibitors (TKIs) is quite uncommon in chronic-phase Chronic Myeloid Leukemia (CML) and related to still poorly understood mechanisms, as ABL mutations are rarely detected in primary resistant patients....
Pseudo-Guillain-Barré syndrome masking acute myeloid leukemia relapse: Brief report and review [0.03%]
假性吉兰-巴雷综合征掩盖急性髓系白血病复发：简短报告及综述
Fadi El Karak,Elie El Rassy,Samer Tabchi et al.
Fadi El Karak et al.
Central nervous system (CNS) relapse is not a rare presentation in acute myeloid leukemia (AML) as its incidence ranges between 2% and 9%. It manifests with meningeal leukemia, cranial nerve palsies or cerebral mesenchymal myeloid sarcoma. ...
Acute acalculous cholecystitis complicating chemotherapy for acute myeloblastic leukemia [0.03%]
急性髓系白血病化疗并发急性非结石性胆囊炎
Olfa Kassar,Feten Kallel,Manel Ghorbel et al.
Olfa Kassar et al.
Acute acalculous cholecystitis is a rare complication in the treatment of acute myeloblastic leukemia. Diagnosis of acute acalculous cholecystitis remains difficult during neutropenic period. We present two acute myeloblastic leukemia patie...
Corrigendum to "Combination therapy with interferon and JAK1-2 inhibitor is feasible. Proof of concept with rapid reduction in JAK2V617F-allele burden in Polycythemia Vera" [Leuk. Res. Rep. 3 (2) (2014) 73-75] [0.03%]
关于“干扰素与JAK1-2抑制剂联合治疗的可行性。与原发性红细胞增多症中JAK2V617F等位基因负荷迅速降低的概念证明”（ leukemia research reports，2014，3（2）：73-75）的勘误
M E Bjørn,K de Stricker,L Kjær et al.
M E Bjørn et al.
[This corrects the article DOI: 10.1016/j.lrr.2014.05.003.].
Published Erratum
Leukemia research reports. 2015 May 15;4(1):31. DOI:10.1016/j.lrr.2015.04.003 2015
Successful pregnancy outcome in paroxysmal nocturnal hemoglobinuria (PNH) following escalated eculizumab dosing to control breakthrough hemolysis [0.03%]
成功在阵发性夜间血红蛋白尿(PNH)中通过增加埃库利珠单抗剂量控制溶血爆发从而获得妊娠结局
Ruby Sharma,Alla Keyzner,Johnson Liu et al.
Ruby Sharma et al.
Pregnancy in women with paroxysmal nocturnal hemoglobinuria (PNH) is associated with increased maternal and fetal morbidity and mortality. There is limited published experience regarding therapy of PNH during pregnancy. We describe a case o...