Genomic imbalances in peripheral blood confirm the diagnosis of myelodysplastic syndrome in a patient presenting with non-immune hemolytic anemia [0.03%]
外周血基因组不平衡证实了非免疫性溶血性贫血患者骨髓增生异常综合征的诊断
Mohammad Faizan Zahid,Nadia Khan,Jianming Pei et al.
Mohammad Faizan Zahid et al.
Myelodysplastic syndrome (MDS) is a clonal stem-cell disorder characterized by dyshematopoiesis. We report a patient who presented with cytopenias and microangiopathic hemolytic anemia. Chromosome microarray analysis (CMA), using single nuc...
Erythroid blast crisis in chronic myelogenous leukemia: Case report and review of literature [0.03%]
慢性粒细胞性白血病红系母细胞危象一例及文献复习
Rochelle Nagales Nagamos,Teresa Gentile,Neerja Vajpayee
Rochelle Nagales Nagamos
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder where over a period of time 15-20% of patients show blastic transformation with majority transforming into acute myeloid leukemia, most of which are of granulocytic lineage...
The formation of an aberrant PAX5 transcript in a patient with mixed phenotype acute leukemia harboring der(9)t(7;9)(q11.2;p13) [0.03%]
染色体异常der(9)t(7;9)(q11.2;p13)的混合表型急性白血病患者PAX5异常转录本形成
Jun Amaki,Hiromichi Matsushita,Yuka Kitamura et al.
Jun Amaki et al.
We experienced the case of a 56-year-old male with B-lymphoid/myeloid lineage mixed phenotype acute leukemia (MPAL). A cytogenetic analysis of the patient's bone marrow revealed a complex karyotype, including der(9)t(7;9)(q11.2;p13). We ide...
Refractory acute promyelocytic leukemia successfully treated with combination therapy of arsenic trioxide and tamibarotene: A case report [0.03%]
三氧化二砷联合蒂美泊醇治疗难治性急性早幼粒细胞白血病1例报告
Minoru Kojima,Daisuke Ogiya,Akifumi Ichiki et al.
Minoru Kojima et al.
A 40-year-old male developed refractory acute promyelocytic leukemia (APL) after various treatments including all-trans retinoic acid, tamibarotene, arsenic trioxide (As2O3), conventional chemotherapy, and autologous peripheral blood stem c...
Clonal evolution of AML on novel FMS-like tyrosine kinase-3 (FLT3) inhibitor therapy with evolving actionable targets [0.03%]
新型FMS样酪氨酸激酶3(FLT3)抑制剂治疗急性髓系白血病时克隆进化及潜在药物靶点的演变
Pashtoon M Kasi,Mark R Litzow,Mrinal M Patnaik et al.
Pashtoon M Kasi et al.
For acute myeloid leukemia (AML), identification of activating mutations in the FMS-like tyrosine kinase-3 (FLT3) has led to the development of several FLT3-inhibitors. Here we present clinical and next generation sequencing data at the tim...
Hidetsugu Kawai,Hiromichi Matsushita,Ken Ohmachi et al.
Hidetsugu Kawai et al.
Hepatosplenic T-cell lymphoma (HSTCL), a rare type of γδ T-cell lymphoma, is characterized by hepatosplenomegaly and cytopenias. It is associated with immunodeficiency and its age of onset is reportedly between the 20s and 30s. We herein ...
An unexpected and devastating adverse event of dasatinib: Rhabdomyolysis [0.03%]
达沙替尼令人意外且严重的不良反应：横纹肌溶解症
Burak Uz,Ilhan Dolasik
Burak Uz
We, herein, describe a 52-year-old male whom developed rhabdomyolysis and acute renal failure likely related to dasatinib shortly after the administration of treatment. After withdrawal of dasatinib, the myalgia reduced, and his CK returned...
Unusual massive bone marrow fibrosis in acute promyelocytic leukemia following arsenic trioxide therapy [0.03%]
三氧化二砷治疗后急性早幼粒细胞白血病合并巨骨髓及重度骨髓纤维化1例报告
S Venkatesan,Abhishek Purohit,Ankur Ahuja et al.
S Venkatesan et al.
Bone marrow fibrosis has been associated with different types of non-neoplastic conditions like granulomatous and autoimmune diseases and a variety of neoplastic disorders such as acute megakaryoblastic leukemia, Hodgkin lymphoma, non-Hodgk...
Young woman with mild bone marrow dysplasia, GATA2 and ASXL1 mutation treated with allogeneic hematopoietic stem cell transplantation [0.03%]
一名骨髓发育异常综合征并有GATA2及ASXL1基因突变的年轻女性接受异基因造血干细胞移植治疗病例报告
Anna Lübking,Sebastian Vosberg,Nikola P Konstandin et al.
Anna Lübking et al.
Heterozygous mutations in GATA2 underlie different syndromes, previously described as monocytopenia and mycobacterial avium complex infection (MonoMAC); dendritic cell, monocytes, B- and NK lymphocytes deficiency (DCML); lymphedema, deafnes...
Detection of a PDGFRB fusion in refractory CMML without eosinophilia: A case for broad spectrum tumor profiling [0.03%]
CMML伴PDGFRB融合的诊断及其对广谱肿瘤检测的意义：一例无嗜酸粒细胞难治性CMML病例报告
Gillian C Bell,Eric Padron
Gillian C Bell
In this case report, we describe a refractory CMML case without eosinophilia harboring a PDGFRB rearrangement leading to a favorable response with imatinib. We believe this case demonstrates the utility of broad spectrum genomic profiling i...