An ETV6-ABL1 fusion in a patient with chronic myeloproliferative neoplasm: Initial response to Imatinib followed by rapid transformation into ALL [0.03%]
一名慢性骨髓增殖性肿瘤患者出现ETV6-ABL1融合：伊马替尼初始治疗后的快速转化为急性淋巴细胞白血病
Purvi M Kakadia,Ralf Schmidmaier,Andreas Völkl et al.
Purvi M Kakadia et al.
We report the case of a 26 year-old patient presenting with a persistent leukocytosis and CML-like marrow but no evidence of a BCR/ABL1 fusion. Molecular cytogenetics revealed that a portion of the ETV6 locus was inserted into the ABL1 locu...
Michael Medinger,Claudia Lengerke,Jakob Passweg
Michael Medinger
Acute myeloid leukemia (AML) is a biologically complex and molecularly and clinically heterogeneous disease, and its incidence is increasing as the population ages. Cytogenetic anomalies and mutation testing remain important prognostic tool...
Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line [0.03%]
CD147通过调节K562/ADR白血病细胞系中P-糖蛋白的表达参与多药耐药性
Aoranit Somno,Songyot Anuchapreeda,Nuttapol Chruewkamlow et al.
Aoranit Somno et al.
The relationship between P-gp and CD147 in the regulation of MDR in leukemic cells has not been reported. This study aimed to investigate the correlation between CD147 and P-gp in the regulation of drug resistance in the K562/ADR leukemic c...
Congenital B-lymphoblastic leukemia with a cryptic MLL rearrangement and post-treatment evolution to mixed phenotype acute leukemia [0.03%]
伴有MLL重排的先天性B淋巴母细胞白血病及向混合表型急性白血病转化的病例报告
Elizabeth Moschiano,Gordana Raca,Cecilia Fu et al.
Elizabeth Moschiano et al.
Congenital leukemia is a rare event with a poor prognosis. We report a case of congenital leukemia with a cryptic rearrangement of MLL demonstrable only with RT-PCR. Interestingly, with treatment, the patient showed lineage plasticity of th...
Enhanced international prognostic index in Japanese patients with diffuse large B-cell lymphoma [0.03%]
日本弥漫性大B细胞淋巴瘤患者的改良国际预后指数
Aya Nakaya,Shinya Fujita,Atsushi Satake et al.
Aya Nakaya et al.
To evaluate the National Comprehensive Cancer Network (NCCN) International Prognostic Index (IPI), we analyzed 284 patients treated with the combination of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in ou...
A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate [0.03%]
西伐他汀联合阿仑膦酸钠治疗真性红细胞增多症1例及其疗效观察
Anders Lindholm Sørensen,Klaus Kallenbach,Hans Carl Hasselbalch
Anders Lindholm Sørensen
We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this pe...
Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short clinical report [0.03%]
IKZF1基因型在费城染色体阴性前体B急性淋巴细胞白血病进展中的改变：简短临床报告
Volha Vshyukova,Alexander Meleshko,Natalia Mihal et al.
Volha Vshyukova et al.
•The case demonstrated a rare event of clonal heterogeneity by IKZF1 gene status in BCRABL1- ALL.•IKZF1 deletions are secondary events in ALL caused by clonal evolution during the treatment.•It's prognostic significance could be more cru...
Eduardo Garza,Giovanni Del Poeta,Carmen Martínez-Losada et al.
Eduardo Garza et al.
Chronic lymphocytic leukemia (CLL) is characterized by extremely variable clinical course indicating substantial differences in the biology of the disease. Molecular characterization provides new insights useful for treatment decision makin...
Chronic lymphocytic lymphoma and concomitant renal cell carcinoma (Clear Cell Type): Review of the literature [0.03%]
慢性淋巴细胞淋巴瘤合并肾细胞癌（透明细胞型）的文献复习
Burak Uz,Ilhan Dolasik,Ozlem Ucer et al.
Burak Uz et al.
In the present report, a 73 years-old male patient who developed clear cell type renal cell carcinoma (RCC) 5 years after the diagnosis of chronic lymphocytic lymphoma (CLL) and plausible explanations for this association were discussed by ...
Antonio M Almeida,Fernando Ramos
Antonio M Almeida
AML is an aggressive hematological malignancy with highest incidence in the older adults. The adverse features of AML in the elderly, and the frailties and comorbidities frequently present in them, make their management a particularly diffi...