Incident adverse events following therapy for acute promyelocytic leukemia [0.03%]
急性早幼粒细胞白血病治疗后的不良事件
Peter Geon Kim,Kelly Bridgham,Evan C Chen et al.
Peter Geon Kim et al.
The use of all-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) with or without cytotoxic chemotherapy is highly effective in acute promyelocytic leukemia (APL) but incident chronic adverse events (AEs) after initiation of th...
Acute myeloid leukemia with t(4;12)(q12;p13) treated with an allogeneic stem cell transplant: A case report and review of the literature [0.03%]
四号和十二号染色体易位的急性髓系白血病接受allo-HSCT治疗：一例报告及文献复习
Christie Hancock,Dimitra Kanaloupitis,Ronald Sirota et al.
Christie Hancock et al.
Secondary clonal hematologic neoplasia following successful therapy for acute promyelocytic leukemia (APL): A report of two cases and review of the literature [0.03%]
急性早幼粒细胞白血病(APL)治疗成功后的克隆性血液系统肿瘤:两例报告及文献回顾
Daria Gaut,Joshua Sasine,Gary Schiller
Daria Gaut
Although rare, secondary clonal hematologic neoplasia may occur after successful therapy for acute promyelocytic leukemia (APL). These secondary clonal events may be considered therapy-related, but may also be due to an underlying backgroun...
Delayed diagnosis of Shwachman diamond syndrome with short telomeres and a review of cases in Asia [0.03%]
延迟诊断的Shwachman-Diamond综合征伴短端粒及亚洲病例综述
Shin Yeu Ong,Shao-Tzu Li,Gee Chuan Wong et al.
Shin Yeu Ong et al.
Inherited bone marrow failure syndrome (IBMFS) including Shwachman Diamond Syndrome (SDS) can present initially to the hematologist with myelodysplastic syndrome (MDS). Accurate diagnosis affects choice of chemotherapy, donor selection, and...
The fear of lymphadenopathy: A cautionary case of sarcoidosis masquerading as recurrent diffuse large b-cell lymphoma (DLBCL) [0.03%]
畏淋巴结病之症：一例以复发性弥漫性大B细胞淋巴瘤(DLBCL)为表现的肉芽肿性疾病警惕病例报告
Peter D Whooley,Russell K Dorer,David M Aboulafia
Peter D Whooley
We describe the cautionary case of a patient with advanced-stage large B-cell lymphoma (DLBCL). After combination chemotherapy, CT-PET revealed a persistent focus of likely DLBCL for which he received radiotherapy. Follow-up CT-PET showed d...
A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia [0.03%]
一例慢性嗜酸性粒细胞白血病二次变异急性髓系白血病病例报告
Mattias Hofmans,Anke Delie,Karl Vandepoele et al.
Mattias Hofmans et al.
The natural history of primary eosinophilia remains highly variable and is characterized by underlying disease heterogeneity. Chronic eosinophilic leukemia, not otherwise specified (CEL-NOS) is a rare and aggressive disease characterized by...
Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia [0.03%]
抗CD19嵌合抗原受体靶向CD19阳性急性髓系白血病
Gina Ma,Yi Wang,Tahmeena Ahmed et al.
Gina Ma et al.
Aberrant expression of CD19 in acute myeloid leukemia (AML) is commonly associated with t(8;21)(q22;q22), although AML cases lacking this translocation occasionally express CD19. Mixed-phenotype acute leukemia also frequently expresses CD19...
1,25-OH2 vitamin D3 and AKT-inhibition increase glucocorticoid induced apoptosis in a model of T-cell acute lymphoblastic leukemia (ALL) [0.03%]
1,25-双氢维生素D3和AKT抑制增加糖皮质激素诱导的T细胞急性淋巴细胞白血病(ALL)凋亡
Maximilian Pistor,Lisa Schrewe,Steffen Haupeltshofer et al.
Maximilian Pistor et al.
In acute lymphoblastic leukemia (ALL), steroid resistance and hypovitaminosis D are both associated with a poor prognosis. We show that methylprednisolone, calcitriol and the AKT-inhibitor MK-2206 have a synergistic effect on the apoptosis ...
Acute promyelocytic leukemia presenting with features of metastatic osseous disease [0.03%]
以转移性骨病表现为特征的急性早幼粒细胞白血病
Carmen Winters,Andy I Chen,Stephen Moore et al.
Carmen Winters et al.
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia defined by a balanced translocation between chromosomes 15 and 17 resulting in fusion of the promyelocytic leukemia gene (PML) on chromosome 15 with the reti...
Forskolin attenuates doxorubicin-induced accumulation of asymmetric dimethylarginine and s-adenosylhomocysteine via methyltransferase activity in leukemic monocytes [0.03%]
姜黄素茋通过甲基转移酶活性减轻异丙肾上腺素诱导的不对称二甲基精氨酸和S-腺苷同型半胱氨酸在白血病单核细胞中的积累
Sandhiya Ramachandran,Swetha Loganathan,Vinnie Cheeran et al.
Sandhiya Ramachandran et al.
Doxorubicin (DOX) is an antitumor drug, associated with cardiomyopathy. Strategies to address DOX-cardiomyopathy are scarce. Here, we identify the effect of forskolin (FSK) on DOX-induced-asymmetric-dimethylarginine (ADMA) accumulation in m...