Inotuzumab ozogamicin as chemotherapy-sparing salvage in a 67-year-old man with primary refractory B-cell acute lymphoblastic leukemia with high-risk genomic features [0.03%]
伊沙佐米抗体药物偶联物作为挽救性治疗，用于具有高危基因组特征的67岁原发难治B细胞急性淋巴细胞白血病患者的化疗减毒方案
Xiaochuan Yang,Filiz Sen,Mark B Geyer
Xiaochuan Yang
Older adults with acute lymphoblastic leukemia (ALL) continue to have a poor prognosis, in part due to greater chemotherapy-related toxicities. We herein report a 67-year-old man with Philadelphia chromosome (Ph)-negative B-cell ALL, who ex...
Genotypic and phenotypic evolution in a patient with chronic myelomonocytic leukemia [0.03%]
一例慢性粒单细胞白血病患者的基因型和表型进化
Klaus Geissler,Eva Jäger,Michael Gurbisz
Klaus Geissler
The correlation of molecular and phenotypic evolution in individual patients with chronic myelomonocytic leukemia (CMML) is poorly investigated. The longitudinal follow up of a CMML patient for more than 10 years illustrates that the emerge...
Mutations of FLT3 receptor affect its surface glycosylation, intracellular localization, and downstream signaling [0.03%]
FLT3受体的突变影响其糖基化、细胞内定位和下游信号转导
Shinichiro Takahashi
Shinichiro Takahashi
This review describes the effects of FLT3 mutations that alter its intracellular localization and modify its glycosylation, leading to differences in downstream signaling pathways. The most common type of FLT3 mutation, internal tandem dupl...
Etoposide-induced DNA damage in a chromosomal breakpoint of RUNX1 gene is independent of RUNX1 expression [0.03%]
依托泊苷诱导的RUNX1基因染色体断裂点DNA损伤不依赖于RUNX1表达
Nicolás Schnake,Soraya Gutiérrez
Nicolás Schnake
In this work, we analyzed the association between RUNX1 gene expression and the accessibility of BCR3, one of RUNX1 gene breakpoint regions involved in the chromosomal translocation (8;21), a frequent translocation in treatment-related acut...
Yumeng Zhang,David M Swoboda,Aditya Grover et al.
Yumeng Zhang et al.
Myeloid Sarcoma (MS) is diagnosed by an extramedullary proliferation of immature granulocytic cells. Its association with chronic myeloid leukemia (CML) is rare. CML is characterized by BCR-ABL1 gene rearrangement and therapies with tyrosin...
Prognostic significance of Fc receptor-like 1 in patients with chronic lymphocytic leukemia, hairy cell leukemia, and various B-cell non-Hodgkin's lymphoma [0.03%]
Fc受体样1在慢性淋巴细胞白血病、毛细胞白血病和各种B细胞非霍奇金淋巴瘤患者中的预后意义
Zahra Yousefi,Nahid Eskandari
Zahra Yousefi
Fc receptor-like 1 (FCRL1) positively regulates B-cell responses and may involve in the pathogenesis of B-cell malignancies. This study examined the expression pattern of FCRL1 in B-cell non-Hodgkin's lymphoma patients using real-time PCR a...
TTP-like syndrome associated with hemoglobin SC disease treated successfully with plasma and red cell exchange [0.03%]
血红蛋白SC病合并TTP样综合征采用血浆置换及红细胞交换治疗获成功
Sreenath Kodali,Preethi Ramachandran,Ivan N Richard et al.
Sreenath Kodali et al.
Background: Sickle cell hemoglobinopathies are associated with end organ damage but very rarely present with a clinical and laboratory picture of microangiopathic hemolytic anemia (MAHA) and thrombocytopenia, characterist...
TTP-like syndrome associated with hemoglobin SC disease treated successfully with plasma and red cell exchange [0.03%]
血红蛋白SC病合并TTP样综合征的病例经血浆置换和红细胞交换治疗获缓解
Sreenath Kodali,Preethi Ramachandran,Ivan N Richard et al.
Sreenath Kodali et al.
Background: Sickle cell hemoglobinopathies are associated with end organ damage but very rarely present with a clinical and laboratory picture of microangiopathic hemolytic anemia (MAHA) and thrombocytopenia, characterist...
Effects of nilotinib on platelet function in patients with chronic myeloid leukemia in chronic phase [0.03%]
尼罗替尼对慢性期慢性髓性白血病患者血小板功能的影响
Alauldeen Mudhafar Zubair Alqasim,Ghasaq Mohsin Obaid,Yusra Ghaith Yaseen et al.
Alauldeen Mudhafar Zubair Alqasim et al.
Background: Tyrosine kinases are highly expressed in platelets and play an important role in their activation process. Some studies have reported the blocking effects of tyrosine kinase inhibitors on different platelet fu...
Rapid progression to AML in a patient with germline GATA2 mutation and acquired NRAS Q61K mutation [0.03%]
携带GATA2 germline突变和获得性NRAS Q61K突变的患者迅速进展为AML
Lisa J McReynolds,Yubo Zhang,Yanqin Yang et al.
Lisa J McReynolds et al.
GATA2 deficiency syndrome is caused by autosomal dominant, heterozygous germline mutations with widespread effects on immune, pulmonary and vascular systems. Patients commonly develop hematological abnormalities including bone marrow failur...