Management of central nervous system involvement in multiple myeloma after autologous hematopoietic stem cell transplantation [0.03%]
自体造血干细胞移植后多发性骨髓瘤中枢神经系统受累的管理
Khatereh Mousavi-Fatemi,Nasrollah Maleki
Khatereh Mousavi-Fatemi
Multiple myeloma (MM) is characterized by uncontrolled clonal proliferation of plasma cells, mainly in bone marrow, and its extramedullary involvement is rare. Central nervous system involvement in MM is a highly aggressive disease with a s...
CSF3R truncation mutations in a patient with B-cell acute lymphoblastic leukemia and a favorable response to chemotherapy plus dasatinib [0.03%]
一名B细胞急性淋巴细胞白血病并携带CSF3R截短突变且对化疗联合达沙替尼治疗反应良好的患者病例报告
Marc S Schwartz,Matthew J Wieduwilt
Marc S Schwartz
Activating mutations in the gene encoding for receptor of colony stimulating factor 3 (CSF3R) are drivers of pathogenesis in chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML). We describe a patient with newly ...
Gholamreza Bahoush,Maryam Vafapour,Roxana Kariminejad
Gholamreza Bahoush
The most common childhood malignancy is acute leukemia. Approximately 15- 20% of it, is Acute myeloid leukemia (AML). The general symptoms of this malignancy include fatigue, weakness, fever, paleness and bleeding disorders. There are two m...
Isolated central nervous system relapse of multiple myeloma post autologous stem cell transplant- A rare presentation [0.03%]
自体干细胞移植后多发性骨髓瘤孤立的中枢神经系统复发的一例罕见病例报告
Abhenil Mittal,Deepam Pushpam,Lalit Kumar
Abhenil Mittal
•CNS relapse in multiple myeloma after ASCT without medullary relapse is uncommon.•Isolated CNS relapse is extremely rare with only 7 cases reported in literature.•Prognosis is poor with very short median survival after detection of CNS ...
Impact of age and induction therapy on outcome of 180 adult patients with acute myeloid leukemia; retrospective analysis and literature review [0.03%]
年龄及不同诱导缓解方案对180例成人急性髓系白血病患者疗效影响的回顾性分析及文献复习
Khadega A Abuelgasim,Bandar Albuhayri,Rayan Munshi et al.
Khadega A Abuelgasim et al.
The prognosis of acute myeloid leukemia (AML) remains poor. Among 180 patients, the median age was 53 (14-88) years. The overall 2-year disease free survival (DFS) was 28.6% (+/- 3.4), 47.7% (+/- 6.6%) for ≤ 40, 23.6% (+/- 5.8%) for 41-60 ...
Spontaneous splenic rupture - An uncommon complication of chronic myelomonocytic leukemia [0.03%]
自发性脾破裂-慢性粒单核细胞白血病的不常见并发症
Abdul Muqtadir Abbasi,Salman Adil,Bushra Moiz
Abdul Muqtadir Abbasi
Prognostic value of CD25/CD123 pattern of expression in acute myeloid leukemia patients with normal cytogenetic [0.03%]
正常核型急性髓系白血病中CD25/CD123表达模式的预后价值分析
Salah Aref,Emaad Azmy,Lamiaa Ibrahim et al.
Salah Aref et al.
This study was designed to assess the significance of interleukin-2 receptor (CD25) and inteleukin-3 receptor (CD123) expression in cytogenetically normal acute myeloid leukemia (CN-AML) patients. The current study includes 80 CN-AML (≤ 60...
Successful Treatment of Ocular Chronic Lymphocytic Leukemia with Ibrutinib: Case Report and Review of the Literature [0.03%]
伊布替尼治疗眼型慢性淋巴细胞白血病一例及文献复习
Ayushi F Chauhan,Narine Viruni,T Y Alvin Liu et al.
Ayushi F Chauhan et al.
Terrence Bradley,Radames Adamo Zuquello,Luis E Aguirre et al.
Terrence Bradley et al.
Acute myeloid leukemia (AML) is defined by the presence of ≥ 20% myeloblasts in the blood or bone marrow. Spontaneous remission (SR) of AML is a rare event, with few cases described in the literature. SR is generally associated with recove...
Acute myeloid leukemia synchronous with multiple myeloma successfully treated by azacytidine/lenalidomide and daratumumab without a decrease in myeloid clone size [0.03%]
阿扎胞苷/来那度胺和达雷木单抗成功治疗急性髓系白血病合并多发性骨髓瘤1例（未见粒系克隆大小减小）
Celine Berthon,Morgane Nudel,Eileen M Boyle et al.
Celine Berthon et al.
Synchronous diagnosis of acute myeloid leukemia (AML) and symptomatic multiple myeloma (MM) is a rare situation that poses serious therapeutic difficulties. We report the case of a 68-year-old male which evolved simultaneously to symptomati...