Targeting nucleotide metabolism and epigenetic regulation to overcome the differentiation blockade in AML [0.03%]
靶向核苷酸代谢和表观遗传调控以克服急性髓系白血病中的分化障碍
Shinichiro Takahashi
Shinichiro Takahashi
Differentiation blockade is a central pathogenic hallmark of acute myeloid leukemia (AML). While all-trans retinoic acid (ATRA) achieves curative differentiation in acute promyelocytic leukemia (APL), this success has not extended to other ...
Synergistic effects of arsenic trioxide and atorvastatin on proliferation and apoptosis in acute lymphoblastic leukemia cells [0.03%]
三氧化二砷与阿托伐他汀对急性淋巴细胞白血病细胞增殖及凋亡的协同作用
Sepideh Hassanpour Khodaei,Shahnaz Sabetkam,Zeinab Mazloumi et al.
Sepideh Hassanpour Khodaei et al.
Statins and arsenic trioxide (ATO) are known for their significant anti-neoplastic properties; however, limited research has investigated their potential synergistic effects. This study explores the individual and combined impact of ATO and...
"Catch-Up Vaccinations Post-Stem Cell Transplant: A case series and review of the literature" [0.03%]
造血干细胞移植后疫苗补种——病例系列及文献回顾
Rehab Mohammed Gaafar,Afnan Mohsen Alamodi
Rehab Mohammed Gaafar
Stem cell transplantation (SCT), including autologous and allogeneic approaches, is a potentially curative therapy for various hematologic malignancies and selected non-malignant disorders. Autologous stem cell transplantation (ASCT) is an ...
Machine learning models in predictive factors for megaloblastic character of macrocytic anemia [0.03%]
机器学习模型在巨幼细胞性大细胞性贫血预测因素中的应用
Melek Kechida,Mohamed Kenani,Nader Slama et al.
Melek Kechida et al.
Background: Differentiating megaloblastic from non-megaloblastic macrocytic anemia usually relies on vitamin B12 and/or B9 assessment and bone marrow examination. In resource-limited regions, these diagnostic tools are no...
Aplastic anaemia with small paroxysmal nocturnal haemoglobinuria clones developing during osimertinib therapy for non-small cell lung cancer [0.03%]
奥西替尼治疗非小细胞肺癌期间出现极少量阵发性夜间血红蛋白尿克隆的再生障碍性贫血病例报告
Hayata Morimoto,Seiichiro Katagiri,Tomokazu Omori et al.
Hayata Morimoto et al.
We report two cases of aplastic anaemia (AA) with small populations of paroxysmal nocturnal haemoglobinuria (PNH)-phenotype cells that developed during osimertinib (OSIM) therapy for epidermal growth factor receptor mutation-positive lung a...
Sirine Chatti,Emna Azza,Marwa Bahri et al.
Sirine Chatti et al.
Introduction: In children, acute promyelocytic leukemia is a distinct and underreported entity. The objective of our study is to report the therapeutic outcomes of APL in the pediatric population. ...
Synergistic effects of luspatercept and cyclosporine A in lower-risk myelodysplastic syndrome with red cell aplasia: Two case insights [0.03%]
低危红系发育不良综合症患者中Luspatercept与环孢素A的协同作用：两例报告的启示
Tatsuro Jo,Takahiro Sakai,Kazuhiro Noguchi et al.
Tatsuro Jo et al.
Luspatercept, an erythroid maturation agent, treats anemia in lower-risk myelodysplastic syndromes (MDS) by inhibiting SMAD2/3 signaling. However, its efficacy may be limited in immune-mediated erythroid suppression. We present two lower-ri...
T-cell receptor anti-CMV CDR3s from bone marrow samples are associated with a worse overall survival for recurrent acute myeloid leukemia [0.03%]
骨髓样本中的T细胞受体抗CMV CDR3与复发性急性髓系白血病的总生存率降低有关
Srijit Paul,Michael T Aboujaoude,Vayda R Barker et al.
Srijit Paul et al.
We assessed the relationship of AML patient outcomes and T-cell receptor (TCR) recombination reads representing known anti-viral TCR sequences. TCR complementary determining region-3's (CDR3s) were obtained from the pediatric TARGET-AML dat...
Blastic plasmacytoid dendritic cell neoplasm: A single centre Indian experience [0.03%]
印度单中心blasctic浆细胞样树突状细胞肿瘤病例分析
Paramasivam Sabitha,Aastha Goel,Santhosh Kumar et al.
Paramasivam Sabitha et al.
BPDCN is an uncommon haematological malignancy recognised as a distinct entity by the WHO in 2016. It typically presents with skin lesions and involves bone marrow, lymph nodes, and CNS, affecting all age groups. The disease poses significa...
Delayed fatal neurotoxicity in post CAR-T cell therapy for multiple myeloma, a case report [0.03%]
CAR-T细胞治疗后多发性骨髓瘤患者的延迟致命神经毒性一例报告
Hamza Khoudari,Abdalla Shoaib,Muhammad Nashatizadeh et al.
Hamza Khoudari et al.
Anti-BCMA CAR T-cell therapy, specifically ciltacabtagene autoleucel, has significantly improved outcomes for relapsed/refractory multiple myeloma (RRMM). While early-onset immune-effector cell-associated neurotoxicity syndrome (ICANS) is a...