Sustained MRD negative remission in del17p and TP53 mutated B cell prolymphocytic leukemia with ibrutinib and venetoclax [0.03%]
伊布替尼和维奈托克使具有缺失17p和TP53突变的B细胞前体淋巴瘤患者持续达到微小残留病变阴性缓解状态
Maria Tariq Siddiqui,Allyson Price,Alessandra Ferrajoli et al.
Maria Tariq Siddiqui et al.
B cell prolymphocytic leukemia is a rare and aggressive disorder often with high risk features including TP53 mutation, deletion 17p and complex karyotype. There is scarcity of data regarding treatment and existing therapies induce short li...
Evaluation of the outcomes in patients with chronic myeloid leukemia treated with imatinib in 18-year follow-up [0.03%]
伊马替尼治疗的慢性髓性白血病患者18年的随访结果评估
Mozafar Aznab,Ali Shahriari-Ahmadi,Fatemeh Heydarpour
Mozafar Aznab
The objective of this paper is to examine the effects of Imatinib on patients who are at the chronic phase of chronic myeloid leukemia (CML). Method: Totally, 79 patients with CML who received the treatment between 2003 and 2020 entered the...
Improved survival in adolescents and young adults (AYA) patients aged 14-55 years with acute lymphoblastic leukemia using pediatric-inspired protocol - a retrospective analysis of a real-world experience in 79 of patients treated at a national tertiary care referral center [0.03%]
基于儿科方案改进的14-55岁青少年和年轻成人急性淋巴细胞白血病患者的生存率 - 国家三级转诊中心79例真实世界经验的回顾性分析
Amr Hanbali,Ahmed Kotb,Riad El Fakih et al.
Amr Hanbali et al.
Background: Treating adolescents and young adults (AYA) patients with acute lymphoblastic leukemia (ALL) using pediatric-inspired protocols have shown improvement in outcomes. Most data available in the literature of such...
Two autopsy cases of pulmonary leukemic infiltration mimicking severe pneumonia in patients with acute myeloid leukemia [0.03%]
急性髓系白血病患者肺部白血病浸润两例尸检报告，误诊为重症肺炎
Hiroko Iizuka,Yosuke Mori,Yasutaka Fukuda et al.
Hiroko Iizuka et al.
Although a previous autopsy series demonstrated that pulmonary leukemic infiltration (PLI) is a major pulmonary complication in patients with acute myeloid leukemia (AML), an antemortem diagnosis of PLI is rare. Diverse pulmonary complicati...
CD47-targeting antibodies as a novel therapeutic strategy in hematologic malignancies [0.03%]
针对CD47的抗体作为血液系统恶性肿瘤中的一种新型治疗策略
Jennifer Sun,Yixuan Chen,Berit Lubben et al.
Jennifer Sun et al.
CD47 is a surface glycoprotein expressed by host cells to impede phagocytosis upon binding to macrophage SIRPα, thereby represents an immune checkpoint known as the "don't-eat-me" signal. However, accumulating evidence shows that solid and...
MRD negative CR after azacitidine and venetoclax in a young patient with AML, unfit for intensive induction followed by ASCT [0.03%]
使用地西他滨和维奈托克达到AML年轻患者（不适合强化诱导治疗）的MRD阴性CR，随后进行ASCT
Deepak Kumar Shukla,Satyendra Katewa,Ravikant Porwal et al.
Deepak Kumar Shukla et al.
A subset of AML patients are unfit for 7+3 induction at the time of diagnosis. Present case highlights the use of azacitidine and venetoclax in a patient with intermediate risk AML with WT-1 mutation,deemed unfit for intensive induction in ...
T-cell Acute Lymphoblastic Leukemia in a Patient with Pre-existing Essential Thrombocythemia: A Case Report and Literature Review [0.03%]
原发性血小板增多症合并T细胞急性淋巴细胞白血病一例及文献复习
Georgio Medawar,Haritha Ackula,Olga Weinberg et al.
Georgio Medawar et al.
The occurrence of T-cell acute lymphoblastic leukemia (T-ALL), on a background of preexisting Philadelphia-negative Myeloproliferative neoplasm is rare. Among the few reported cases where no deep molecular sequencing was performed, it was d...
Systemic vs. intrathecal central nervous system prophylaxis in primary adrenal/renal diffuse large b-cell LYMPHOMA: A multi-institution retrospective analysis and systematic review [0.03%]
原发性肾上腺/肾脏弥漫大B细胞淋巴瘤中枢神经系统预防策略的多中心回顾分析和系统评价
John Xie,Albert Jang,Motohide Uemura et al.
John Xie et al.
Primary adrenal lymphoma (PAL) and primary renal lymphoma (PRL) are rare extranodal lymphomas, predominantly of diffuse large B-cell lymphoma subtype. Primary adrenal and renal lymphomas (PARL) exhibit a high predilection for the central ne...
A case report of blastic plasmacytoid dendritic cell neoplasm in a hispanic child [0.03%]
一例儿童颗粒细胞浆样树突细胞肿瘤病例报告
Katy Ordoñez Tanchiva,Pamela Contreras Chavez,Silvana Lucero Loli Guevara et al.
Katy Ordoñez Tanchiva et al.
Plasmacytoid dendritic cell neoplasms are aggressive and rare hematologic malignancies characterized by clonal expansion of plasmacytoid dendritic cells with frequent cutaneous involvement. The pathogenesis is not well established, and it s...
Chronic myelogenous leukemia occurring in two brothers: The opposite sides of the same coin? [0.03%]
两兄弟并发慢性粒细胞白血病——同币之异面？
Evgenia Verrou,Kyriaki Tsirou,Nikolaos Karampatzakis et al.
Evgenia Verrou et al.
Herein we present a rare case of two brothers diagnosed with CML four years apart. Importantly, our case of CML occurrence among siblings is the fifth one reported and the second one investigated by both, conventional cytogenetics and RT-PC...