Avapritinib treatment of aggressive systemic mastocytosis with a novel KIT exon 17 mutation [0.03%]
阿伐普利尼布治疗携带KIT 外显子17突变的侵袭性系统性肥大细胞增生症
Lyndsey Sandow,Ajia Town,Michael C Heinrich
Lyndsey Sandow
Background: Systemic mastocytosis is a rare hematologic malignancy that leads to the accumulation of neoplastic mast cells in the bone marrow, visceral organs, and skin. Mutations in the receptor tyrosine kinase, KIT are ...
IDH2-mutated near ETP-ALL with aggressive leukemia cutis and brisk response to venetoclax and decitabine [0.03%]
IDH2突变近ETP-ALL伴有严重的皮肤白血病和对维奈托克及地西他滨的快速反应
Poorva Vaidya,Huan-You Wang,Michelle D Don et al.
Poorva Vaidya et al.
Near early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare hematologic malignancy, for which second line therapeutic options are limited. T-cell leukemias are also rarely associated with leukemia cutis, which is more often...
Ricardos Ghanem,Sylvie Glaisner,Arthur Bobin et al.
Ricardos Ghanem et al.
Posterior reversible encephalopathy syndrome (PRES) has rarely been described in myeloma, but chemotherapy is a known risk factor. We report 3 patients with myeloma who developed PRES, and analyzed them with 13 published cases, mostly women...
Is Bartonella sp. infection relevant in hematological malignancies in HIV-negative patients? A literature review [0.03%]
Bartonella感染在HIV阴性的血液系统恶性肿瘤中是否相关？一项文献综述
Elisa Nunes Secamilli,Marina Rovani Drummond,Juliana Yumi Massuda Serrano et al.
Elisa Nunes Secamilli et al.
Bartonelloses are diseases caused by Bartonella sp., transmitted to humans by blood sucking arthropod vectors. Clinical presentations include bacillary angiomatosis, cat scratch disease and atypical forms. We performed a review of cases of ...
Successful anti-tumor effects with two novel bifunctional chemotherapeutic compounds that combine a LAT1 substrate with cytotoxic moieties in aggressive T-cell lymphomas [0.03%]
两种新型双功能化疗化合物在治疗侵袭性T细胞淋巴瘤中成功的抗肿瘤效果：将LAT1底物与细胞毒性成分结合
Carlos Murga-Zamalloa,Shaun Webb,John Reneau et al.
Carlos Murga-Zamalloa et al.
T-cell lymphomas are aggressive neoplasms characterized by poor responses to current chemotherapeutic agents. Expression of the l-type amino acid transporter 1 (LAT 1, SLC7A5) allows for the expansion of healthy T-cell counterparts, and upr...
Epidemiological and clinical characteristics of adult acute lymphoblastic leukemia patients in Chile: A single-center analysis [0.03%]
智利成人急性淋巴细胞白血病患者的流行病学和临床特征的单中心分析
Joaquín Jerez,Valentina Goldschmidt,María Carolina Guerra et al.
Joaquín Jerez et al.
Background: Acute lymphoblastic leukemia represents 20% of acute leukemias in adults. Currently, there is limited data in Chile regarding the clinical, cytogenetic, and prognostic characteristics of this condition. ...
Acute myeloid leukemia cutis with KMT2A::MLLT3 fusion presenting with leonine facies [0.03%]
具有KMT2A::MLLT3融合基因的急性髓系白血病伴有狮面外观
Bret Wankel,Muhammad Afzal,Eric Y Loo et al.
Bret Wankel et al.
A 63-year-old woman presented with plaques covering 60 % body-surface-area and leonine facies. Blood work showed no diagnostic aberrancies. Skin biopsy contained a malignant CD4+/CD56+ mononuclear cell population concerning for blastic plas...
A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome [0.03%]
诺那综合征儿童罕见高级胶质母细胞瘤，脑脓肿和急性淋巴细胞性白血病并发病例报告
Wiem Boufrikha,Rim Rakez,Inaam Bizid et al.
Wiem Boufrikha et al.
Noonan syndrome is a genetic disorder frequently caused by PTPN11 mutations. Patients with Noonan syndrome are characterized by facial dysmorphism, short stature and congenital heart defects and they have a reported predisposition to malign...
Intravascular large B-cell lymphoma masquerading as stroke successfully treated with R-Hyper-CVAD [0.03%]
以中风面目出现的成功用R-Hyper-CVAD治疗的血管内大B细胞淋巴瘤
Christopher Popiolek,Kanchan Gupta,Mallorie L Huff et al.
Christopher Popiolek et al.
Intravascular large B cell lymphoma (IVLBCL) is exceedingly rare and difficult to diagnose. We describe a case of IVLBCL in a 56-year-old male which was identified after recurrent strokes. Right partial nephrectomy was then performed which ...
Venetoclax monotherapy as front-line therapy for blastic plasmacytoid dendritic cell neoplasm [0.03%]
用于毛细胞白血病样疾病/树突状细胞肿瘤初治患者的唯可来单药治疗方案
Ankit Mitesh Shah,Denise Pereira,Julio Poveda et al.
Ankit Mitesh Shah et al.
Venetoclax is an approved treatment for relapsed/refractory Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN). We report a unique case of venetoclax monotherapy used for front-line induction and as a bridge to allogeneic hematopoietic st...