Tyrosine kinase inhibitors modulate the expression of peroxiredoxins 1 and 2 in chronic myeloid leukemia cells [0.03%]
酪氨酸激酶抑制剂调节慢性髓性白血病细胞中过氧化氢酶体蛋白1和2的表达
Hiroshi Kazama,Yan-Hua Wang,Junji Tanaka
Hiroshi Kazama
Chronic myeloid leukemia (CML) is characterized by the presence of the BCR::ABL1 fusion protein with active tyrosine kinase activity. The BCR::ABL1 fusion protein induces the production of reactive oxygen species (ROS). DNA damage caused by...
The road not taken: Exploring non-transplant options in De Novo philadelphia positive acute myeloid leukemia [0.03%]
未被选择的道路：探讨新型Ph阳性急性髓系白血病的非移植治疗选项
Mohamed I Sharif,Ahmad S Alotaibi,Ruah Alyamany et al.
Mohamed I Sharif et al.
Acute myeloid leukemia (AML) is a heterogeneous disease with diverse molecular cytogenetic characteristics. Philadelphia-positive acute myeloid leukemia, a rare subtype of AML, is traditionally considered a high-risk, with the standard reco...
Case report: Rechallenge with gilteritinib after acute pancreatitis in FLT3-positive AML [0.03%]
病例报告：FLT3阳性AML患者出现急性胰腺炎后重新使用吉特替尼治疗
Taner Tan,Genco Gençdal,Ümit Barbaros Üre et al.
Taner Tan et al.
Clonal eosinophilia with exclusive pulmonary involvement driven by PDGFRA rearrangement treated with imatinib: A case report [0.03%]
PDGFRA重排驱动的仅具有肺部受累的克隆性嗜酸性粒细胞增多症的伊马替尼治疗一例报告
Zaineb Mlayah,Inés Ben-Rekaya,Inaam Bizid et al.
Zaineb Mlayah et al.
Hypereosinophilic syndrome (HES) was first described in 1968 by Hardy and Anderson. It is a group of rare, multisystemic and heterogeneous pathologies, characterized by significant morbidity and mortality. The occurrence of clonal hypereosi...
Trans-differentiation of plasma cell neoplasm to acute myeloid leukemia with monocytic features: Case report of divergent phenotype with identical genotype [0.03%]
等浆细胞肿瘤转分化为急性单核细胞白血病的病例报道：表型不同但基因型相同的现象
Saja Asakrah,Kristin K Deeb,Nikolaos Papadantonakis et al.
Saja Asakrah et al.
Myeloid malignancies following treatment for plasma cell neoplasms (PCN) are infrequent but is a serious complication, often exhibiting complex karyotype and TP53 mutations. Plasma cell myeloma lineage switch to a myeloid malignancy with ev...
A rare presentation of multiple myeloma with concurrent paraskeletal extramedullary thoracic plasmacytoma: A case report [0.03%]
一罕见的多发性骨髓瘤病例报告：伴发胸椎旁异位浆细胞瘤
Saja I AbuGhannam,Celina R Andonie,Yousef Abu Asbeh et al.
Saja I AbuGhannam et al.
Multiple myeloma is a hematological malignancy that results from the proliferation of abnormal plasma cells, typically invading the bone marrow but occasionally involving other areas of the body. We present a rare case of a 58-year-old male...
Comprehensive analysis of Atypical chronic myeloid leukemia (aCML): Epidemiology, clinical features, and survival outcomes based on SEER database insights [0.03%]
综合分析非典型慢性髓系白血病（aCML）：基于SEER数据库的流行病学、临床特征和生存结果分析
Zhaoyang Hong,Fan Wang
Zhaoyang Hong
Background: Atypical Chronic Myeloid Leukemia (aCML) is a rare and aggressive myelodysplastic syndrome/myeloproliferative neoplasm. This study aimed to provide a comprehensive understanding of the epidemiology, clinical c...
Retreatment with brentuximab vedotin for discordant peripheral T-cell lymphomas [0.03%]
对于外周T细胞淋巴瘤异质性复发的患者再用brentuximab vedotin治疗
Gen Hasegawa,Noriharu Nakagawa,Yoshimichi Ueda et al.
Gen Hasegawa et al.
Brentuximab vedotin (BV) has demonstrated efficacy against CD30+ peripheral T-cell lymphoma (PTCL). We herein report a case of CD30+ peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) that emerged one month after completing BV, ...
Proteasome inhibitors prevent tumor cell proliferation in HHV-8-unrelated PEL-like lymphoma [0.03%]
蛋白酶体抑制剂可预防与HHV-8无关的类PEL淋巴瘤细胞增殖
Kiyotaka Kawauchi,Toshie Ogasawara
Kiyotaka Kawauchi
Primary effusion lymphoma (PEL)-like lymphoma is a rare variant of PEL that exhibits diverse clinical behaviors, ranging from mild to aggressive disease courses. The clinicopathological features and effective treatments for this type of lym...
FLT3 and NPM1 mRNA expression-based risk stratification of de novo acute Myeloid Leukemia [0.03%]
基于FLT3和NPM1的mRNA表达对新发急性髓系白血病的风险分层研究
Donghyun Kim,Grerk Sutamtewagul,Yeonhwa Yu
Donghyun Kim
Prognostication of acute myeloid leukemia (AML) at initial diagnosis relies on identification of pre-determined underlying genetic abnormalities. Nevertheless, the disease course of AML remains highly unpredictable and robust reliable progn...