Chronic heart failure with reduced EF: A decade of major pharmacological innovations [0.03%]
射血分数降低的慢性心力衰竭：过去十年主要药物创新疗法回顾
Jean-Noël Trochu
Jean-Noël Trochu
Background and objectives: Because of its severity, prevalence, and medical economic importance, heart failure is a chronic disease that is the subject of intense medical research. The aim of this article was to review th...
Galia Pollock,Olivier Negre,Jean-Antoine Ribeil
Galia Pollock
Gene therapy is an innovative strategy that offers potential cure for patients with sickle cell disease, and no appropriate donor for transplant consideration. While we await long term data from these clinical trials, we remain optimistic t...
The ongoing challenge of RBC alloimmunization in the management of patients with sickle cell disease [0.03%]
镰状细胞病患者管理中红细胞输注免疫化的应对挑战
Daniel Y Chang,Zakary Wankier,Connie M Arthur et al.
Daniel Y Chang et al.
RBC transfusion remains a cornerstone in the treatment of sickle cell disease (SCD). However, as with many interventions, transfusion of RBCs is not without risk. Allogeneic RBC exposure can result in the development of alloantibodies, whic...
Christophe Duvoux,Lorraine Blaise,Jean-Jacques Matimbo et al.
Christophe Duvoux et al.
Liver involvement in SCD patients is frequent but often misdiagnosed or underestimated, except in case of advanced liver diseases. Because of so far poorly recognized forms of chronic SCD-related vascular injury that can silently evolved to...
Presentation of polymyalgia rheumatica and large joint polyarthritis in the spectrum of hyper-IgG4-related disease: A case report and literature review [0.03%]
高IgG4相关疾病谱系中多肌炎和大关节多关节炎的临床表现：病例报告及文献复习
Remi Roeland,Marine Trenec,Samuel Deshayes et al.
Remi Roeland et al.
Main nose-throat-ears, and ophthalmic features in sickle cell disease children [0.03%]
儿童镰状细胞病的主要鼻咽部和眼部特征
Léon Tshilolo,Joseph Kelekele
Léon Tshilolo
Screening for cognitive impairment in adults with sickle cell disease: A systematic review and meta-analysis [0.03%]
血红蛋白SC病成人患者认知障碍筛查的系统评价和meta分析
Maryline Couette,Justine Roy,Damien Oudin Doglioni et al.
Maryline Couette et al.
Neurovascular disease such as symptomatic stroke, silent brain infarcts and vascular cognitive impairment are common complications of sickle cell disease (SCD) that can have devastating consequences on quality of life, employment, and socia...
Marie-Sophie Meuleman,Lubka T Roumenina,Anne Grunenwald
Marie-Sophie Meuleman
Sickle Cell Disease (SCD) is a hereditary blood disorder characterized by the presence of abnormal hemoglobin, leading to the formation of sickle-shaped red blood cells, causing vaso-occlusion. Inflammation is a key component of the pathoph...
Salma Al Kahf,Anne Roche,Audrey Baron et al.
Salma Al Kahf et al.
Sickle cell disease (SCD) is a complex genetic disorder that has long challenged both patients and healthcare professionals. One of its chronic and debilitating complications is pulmonary hypertension (PH). SCD-associated PH is often post-c...
Pablo Bartolucci
Pablo Bartolucci