Christopher B Bosma,Wassim W Labaki,MeiLan K Han
Christopher B Bosma
Background and objectives: The ability to identify individuals at risk for progression to chronic obstructive pulmonary disease (COPD) remains challenging. The concept of pre-COPD has been proposed as a framework to ident...
Update on the pathogenetic hallmarks of chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病的发病标志的最新研究进展
Ken R Bracke,Guy G Brusselle
Ken R Bracke
Chronic Obstructive Pulmonary Disease (COPD) is a major cause of global morbidity and mortality, affecting over 300 million individuals worldwide. While traditionally linked to tobacco smoking, increasing evidence highlights the contributio...
Nicolas Roche
Nicolas Roche
Jean Bourbeau,Claudia LeBlanc
Jean Bourbeau
COPD is a chronic condition that comes with a significant symptoms burden and healthcare utilization. It is the fourth leading cause of death worldwide and its prevalence is expected to rise in the years to come. We know that pharmacologica...
The evolving epidemiology, disease trajectories and etiotypes of COPD [0.03%]
不断演变的慢性阻塞性肺疾病的流行病学、疾病轨迹和病因类型
Dagmar Düsterhöft,Jaime Alvarado,Daiana Stolz
Dagmar Düsterhöft
Chronic Obstructive Pulmonary Disease (COPD) remains a leading cause of morbidity and mortality worldwide. This review explores the evolving epidemiology of COPD with a focus on recent trends, disease trajectories, and emerging etiotypes. T...
Personalizing COPD care: phenotypes, endotypes, GETomics, the the trajectome, syndemics and treatable traits [0.03%]
慢性阻塞性肺病的个性化治疗：表型、内型、遗传因素与疾病转归、症候流行病学和可治疗特征
Alvar Agusti,Rosa Faner
Alvar Agusti
Our understanding and management of chronic obstructive pulmonary disease (COPD) has changed significantly over the past few years. We now recognize that COPD is a complex and heterogeneous condition that requires personalized and precise m...
Augusta Beech,Dave Singh
Augusta Beech
The pharmacological management of chronic obstructive pulmonary disease (COPD) focuses on the alleviation of symptoms coupled with exacerbation prevention. Inhaled treatments are the mainstay of management, ensuring adequate lung delivery w...
Sachin Ananth,Jadwiga A Wedzicha
Sachin Ananth
Exacerbations of chronic obstructive pulmonary disease (COPD) lead to significant mortality, morbidity and healthcare expenditure globally. COPD exacerbations are heterogenous events; triggers and risk factors include respiratory infections...
Effects of thyroid disruption on neural cells stem fate in the mouse brain [0.03%]
甲状腺功能紊乱对鼠脑神经干细胞命运的影响
V Valcarcel-Hernandez,L Butruille,S Remaud
V Valcarcel-Hernandez
Thyroid hormones (THs), particularly T3 and T4, play crucial roles in neural development and maintenance by regulating neural stem cell (NSC) proliferation, differentiation, and survival. In the subventricular zone (SVZ), a neurogenic niche...
From stem cells to organoids in thyroid: useful tools or a step for cell therapy? [0.03%]
甲状腺类器官：有用的工具还是细胞治疗的一步？
Dulanjalee Kariyawasam,Athanasia Stoupa,Adrien Nguyen Quoc et al.
Dulanjalee Kariyawasam et al.
Organoids are three-dimensional tissue cultures derived from stem cells. They replicate the complexity of different cell types in an organ and can survive in specific media. They also have the capacity to proliferate and self-renew. Thyroid...