The Use of Small Molecules to Correct Defects in CFTR Folding, Maturation, and Channel Activity [0.03%]
用于修正CFTR折叠、成熟及通道活性缺陷的小分子应用
Meredith F N Rosser,Diane E Grove,Douglas M Cyr
Meredith F N Rosser
Cystic Fibrosis, one of the most common inherited lethal disease among Caucasians, is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. The CFTR protein acts as a gated Cl- channel at the apical mem...
Chemistory of Fibrates [0.03%]
纤维酸类化合物的发展史
Ganesaratnam K Balendiran,Malkhey Verma,Elise Perry
Ganesaratnam K Balendiran
Since the description of the synthetic chemical clofibrate in 1962, various derivatives of fibrates with a diversity of chemical structures have been developed. Several of these are used clinically to treat dyslipidemia because they are gen...
The Phosphobase Methylation Pathway in Caernorhabditis elegans: A New Route to Phospholipids in Animals [0.03%]
秀丽杆线虫中的磷基甲基化途径：动物中磷脂的新合成路线
Soon Goo Lee,Joseph M Jez
Soon Goo Lee
Parasitic nematodes are a major cause of human health problems with an estimated 1 billion people infected worldwide by these organisms. Identifying biochemical targets that differ between the parasite and host species is essential for find...
Gankyrin Oncoprotein: Structure, Function, and Involvement in Cancer [0.03%]
Gankyrin癌蛋白：结构、功能及其在癌症中的作用
Junan Li,Yi Guo
Junan Li
Gankyrin, a newly defined oncoprotein also known as PSMD10 and P28, functions as a dual-negative regulator of the two most prominent tumor suppressor pathways, the CDK/pRb and HDM2/P53 pathways. Its aberrant expression has been prevalently ...
Novel Citronellyl-Based Photoprobes Designed to Identify ER Proteins Interacting with Dolichyl Phosphate in Yeast and Mammalian Cells [0.03%]
新型柠檬烯基光探针可识别酵母和哺乳动物细胞中与多胺焦磷酸相互作用的内质网蛋白
Jeffrey S Rush,Thangaiah Subramanian,Karunai Leela Subramanian et al.
Jeffrey S Rush et al.
Background: Dolichyl phosphate-linked mono- and oligosaccharides (DLO) are essential intermediates in protein N-glycosylation, C- and O-mannosylation and GPI anchor biosynthesis. While many membrane proteins in the endopl...
Gadi Borkow
Gadi Borkow
Copper has two key properties that are being exploited in consumer and medical device products in the last decade. On the one hand, copper has potent biocidal properties. On the other hand, copper is involved in numerous physiological and m...
Environmental contaminants perturb fragile protein assemblies and inhibit normal protein function [0.03%]
环境污染物干扰脆弱的蛋白质聚合体并抑制正常的蛋白质功能
Sarah H Lawrence,Trevor Selwood,Eileen K Jaffe
Sarah H Lawrence
The molecular mechanisms whereby small molecules that contaminate our environment cause physiological effects are largely unknown, in terms of both targets and mechanisms. The essential human enzyme porphobilinogen synthase (HsPBGS, a.k.a. ...
Alejandro Cassola
Alejandro Cassola
Trypanosomes are protozoan parasites responsible for recalcitrant infectious diseases such as Sleeping sickness and Chagas disease in Africa and America, respectively. Their complex life-cycles are accompanied by alternation of forms specif...
Diving Into the Lipid Bilayer to Investigate the Transmembrane Organization and Conformational State Transitions of P-type Ion ATPases [0.03%]
潜入脂质双层研究P型离子ATP酶跨膜组织及构象状态转换
Irene C Mangialavori,Ariel J Caride,Rolando C Rossi et al.
Irene C Mangialavori et al.
Although membrane proteins constitute more than 20% of the total proteins, the structures of only a few are known in detail. An important group of integral membrane proteins are ion-transporting ATPases of the P-type family, which share the...
Karthik Raman,Balagurunathan Kuberan
Karthik Raman
Heparan sulfate proteoglycans (HSPGs) play vital roles in every step of tumor progression allowing cancer cells to proliferate, escape from immune response, invade neighboring tissues, and metastasize to distal sites away from the primary s...