E84G mutation in dihydrofolate reductase from drug resistant strains of Mycobacterium tuberculosis (Mumbai, India) leads to increased interaction with Trimethoprim [0.03%]
来自印度孟买耐药结核分枝杆菌株的二氢叶酸还原酶(E84G)突变体与甲氧苄氨嘧啶的相互作用增强
Archana Raju,Savita Kulkarni,M K Ray et al.
Archana Raju et al.
Background: Dihydrofolate reductase (DHFR) (dfrA gene) is an essential enzyme for cell survival and an unexplored target in Mycobacterium tuberculosis (Mtb). This study was carried out to analyze mutations in the dfrA gen...
Samuel Halstrom,Patricia Price,Rachel Thomson
Samuel Halstrom
Pulmonary infections with nontuberculous mycobacteria (NTM) are recognized as a problem in immunodeficient individuals and are increasingly common in older people with no known immune defects. NTM are found in soil and water, but factors in...
Efficacy and safety of isoniazid preventive therapy in light of increasing multi-drug resistance in tuberculosis [0.03%]
结核病多重耐药性增加背景下异烟肼预防治疗的有效性和安全性
Lingaraja Jena,Bhaskar C Harinath
Lingaraja Jena
A 7-year-old girl with multiple skin ulcers: Case report and literature review [0.03%]
多发性皮肤溃疡患儿的临床病例及文献回顾
Eman Sobh,Amira Bahour,Sahar Elsayed et al.
Eman Sobh et al.
Introduction: There has been an increase in the number of tuberculosis (TB) cases worldwide, but TB of the skin remains rare. Case presentation: ...
Mohamed Ali Sbai,Sofien Benzarti,Monia Boussen et al.
Mohamed Ali Sbai et al.
Tuberculosis is a major public health problem in developing countries. Flexor tenosynovitis of the fingers constitutes an exceptional tuberculosis localization (Gabl et al., 1997; Senda et al., 2011) [1,2]. Unusual presentations, such as tu...
Sequence comparison of six human microRNAs genes between tuberculosis patients and healthy individuals [0.03%]
结核病患者与健康人六种人microRNAs基因的序列比较分析
A Amila,A Acosta,M E Sarmiento et al.
A Amila et al.
Objective/background: MicroRNAs (miRNAs) play an important role in diseases development. Therefore, human miRNAs may be able to inhibit the survival of Mycobacterium tuberculosis (Mtb) in the human host by targeting criti...
Ramon E A Jacobs,Ping Gu,Abraham Chachoua
Ramon E A Jacobs
Reactivation of Mycobacterium tuberculosis can occur in patients with latent tuberculosis (TB) with risk factors including chronic disease (i.e., malignancy). We herein describe the case of an immigrant from Hong Kong with lung cancer and n...
Virtual screening studies to identify novel inhibitors for Sigma F protein of Mycobacterium tuberculosis [0.03%]
针对结核杆菌Sigma F蛋白的虚拟筛选研究以发现新型抑制剂
Kiran Kumar Mustyala,Vasavi Malkhed,Venkataramana Reddy Chittireddy et al.
Kiran Kumar Mustyala et al.
Tuberculosis (TB) is one of the oldest threats to public health. TB is caused by the pathogen Mycobacterium tuberculosis (MTB). The Sigma factors are essential for the survival of MTB. The Sigma factor Sigma F (SigF) regulates genes express...
Diabetes mellitus and its influence on sputum smear positivity at the 2nd month of treatment among pulmonary tuberculosis patients in Kuala Lumpur, Malaysia: A case control study [0.03%]
糖尿病对马来西亚吉隆坡肺结核患者治疗两个月时痰涂片阳性的 影响： 病例对照研究
Noorsuzana Mohd Shariff,Nazarudin Safian
Noorsuzana Mohd Shariff
Objective/background: Many studies have suggested that sputum smear conversion after 2 months of antituberculosis treatment is an important determinant of treatment success and can be a predictor for relapse. The objectiv...
Hookworm infection among patients with pulmonary tuberculosis: Impact of co-infection on the therapeutic failure of pulmonary tuberculosis [0.03%]
肺结核患者中的钩虫感染及合并感染对肺结核治疗失败的影响
Ahmad Farooq Alsayed Hasanain,Ali Abdel-Azeem Hasan Zayed,Reem Ezzat Mahdy et al.
Ahmad Farooq Alsayed Hasanain et al.
Objective/background: The aim of this study is to determine the rate of hookworm infection among patients with pulmonary tuberculosis (TB) and to find out if there is a relation between hookworm infection and the therapeu...