In-Depth Analysis of AG73-Dental Pulp Cell Interactions Underlying Adhesion and Mineralization: Insights from Alanine Scanning [0.03%]
基于甘氨酸扫描的牙髓细胞相互作用的深入分析：附着和矿化的见解
Jia Tang,Akimi Muramatsu,Youjing Qiu
Jia Tang
Background: This study aimed to explore the dental applications of AG73, a laminin-derived adhesive peptide, by examining its effects on human dental pulp cells (hDPCs), particularly in cell adhesion and mineralization. I...
Potentiated Maturation of hPSC-Derived Dopaminergic Neurons via Convergent Genetic and Small Molecule Modulation [0.03%]
通过基因和小分子的协同调节高效诱导人多能干细胞向多巴胺能神经元分化成熟
Sanghyun Park,Dongyun Kim,Seo Hyun Yoo et al.
Sanghyun Park et al.
Background: Ventral midbrain dopaminergic (vmDA) neurons derived from human pluripotent stem cells provide a powerful platform for modeling Parkinson's disease (PD) and developing therapeutic strategies. Although robust p...
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Diabetic β-Cell Apoptosis and Dedifferentiation by Delivering miR-4436 [0.03%]
间充质干细胞来源的细胞外囊泡通过递送miR-4436抑制糖尿病β细胞凋亡和去分化
Jianbo Xu,Yuntong Sun,Fengtian Sun
Jianbo Xu
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by β-cell dysfunction and insulin resistance with limited treatment options. The targeting of pancreatic β-cell apoptosis and ded...
Intratumoral Injectable Click-Crosslinked Hyaluronic Acid Depot for Sustained Gemcitabine Delivery [0.03%]
一种用于持续递送吉西他滨的体内交联透明质酸药物储库
Kyung Eun Son,Yejin Lee,Yejin Kim et al.
Kyung Eun Son et al.
Background: Gemcitabine (GE) is a widely used chemotherapeutic agent for solid tumors; however, its therapeutic efficacy is often compromised by rapid diffusion from the tumor site and insufficient intratumoral retention ...
Pressure-Regulated Chondrogenesis of BMSCs: Static Negative Pressure Primes Differentiation through Apoptotic Vesicles [0.03%]
压力调节骨髓间充质干细胞软骨分化：静态负压通过凋亡小体促进分化
Shuaishuai Zhang,Yanzheng Liu,Yue Zhu et al.
Shuaishuai Zhang et al.
Background: It was found that pressure can promote the regeneration and repair of cartilage defects based on bone marrow mesenchymal stem cells (BMSCs). Since the compressive microenvironment of the cartilage in vivo may ...
Differential Wound Healing Potential of Tonsil Parenchymal and Epithelial Mesenchymal Stromal Cell-Derived Exosomes [0.03%]
腭扁桃体间叶基质细胞来源的外泌体的伤口愈合潜能差异性研究
Harry Jung,Hyeonsun Kim,Jihyeon Lee et al.
Harry Jung et al.
Background: The biological characteristics of mesenchymal stromal cells (MSCs) and their exosomes can vary depending on the tissue layer of origin, potentially influencing their regenerative capacity. This study aimed to ...
Remote Ischemic Preconditioning Enhances Skin Flap Survival via ZNF667/SDF1-Mediated Endothelial Progenitor Cells Functions for Angiogenesis [0.03%]
远程缺血预处理通过ZNF667/SDF1介导的内皮祖细胞功能促进创面愈合血管生成及皮瓣成活的作用及其机制研究
Yuanbin Li,Jingzhang Li,Zhonglei Liang et al.
Yuanbin Li et al.
Background: Flap transplantation plays a vital role in wound reconstruction. However, the mechanisms by which remote ischemic preconditioning (RIPC) may improve flap survival remain incompletely understood. ...
Thermosensitive Injectable Hydrogel Incorporating Telopeptide-Free Type I Collagen Promotes Cartilage Regeneration: An In Vivo Study [0.03%]
一种促进软骨再生的可注射温敏型无telopeptideⅠ型胶原蛋白水凝胶：体内研究
Lilan Gao,Henglin Zhang,Xianglong Lin et al.
Lilan Gao et al.
Background: In cartilage tissue engineering, successfully mimicking the natural extracellular matrix is essential for promoting hyaline cartilage regeneration. The triple-helix structure of collagen has been identified as...
Harnessing Artificial Intelligence for Regeneration of Endometrium in Asherman's Syndrome [0.03%]
人工智能在Asherman综合征子宫内膜再生中的应用探讨
Gokulnath Anbalagan,Namasivaya Naveen Shanmuga Sundaram,Nandakumar Venkatesan
Gokulnath Anbalagan
Background: Asherman's Syndrome or intrauterine adhesions develop due to acquired endometrium damage, resulting in partial to complete dysfunction of the endometrium within the uterine cavity. The pathophysiology of these...
Effect of hUCMSC-sEV-Loaded GelMA Microspheres on Pulp/Dentin Repair and Regeneration [0.03%]
人脐带间质干细胞源外泌体载药明胶甲基酯微球对牙髓/牙本质再生的影响
Xinping Lu,Huidan Deng,Ruotong Mai et al.
Xinping Lu et al.
Background: This study evaluated the biocompatibility of small extracellular vesicles (sEVs) derived from human umbilical cord mesenchymal stem cells (hUCMSC) loaded in gelatin methacryloyl hydrogel microspheres (sEVs@GM-...