Crystalline Ethylene Oxide and Propylene Oxide Triblock Copolymer Solid Dispersion Enhance Solubility, Stability and Promoting Time- Controllable Release of Curcumin [0.03%]
晶态环氧乙烷和环氧丙烷三嵌段共聚物固体分散体系增强姜黄素溶解度及稳定性并促进姜黄素的可控释药
Thais F R Alves,Franciely C C das Neves Lopes,Marcia A Rebelo et al.
Thais F R Alves et al.
Aims and background: The design and development of an effective medicine are, however, often faced with a number of challenges. One of them is the close relationship of drug's bioavailability with solubility, dissolution ...
Ryan F Donnelly
Ryan F Donnelly
Patented and Approval Scenario of Nanopharmaceuticals with Relevancy to Biomedical Application, Manufacturing Procedure and Safety Aspects [0.03%]
纳米药物的专利及审批情景及其与生物医学应用、制造过程和安全因素的相关性
Vijay Agarwal,Meenakshi Bajpai,Ashish Sharma
Vijay Agarwal
Background: Nanopharmaceutical is the field that arises gradually but many challenges are also still there. This review aims to identify these challenges and give the focus on their rectification. ...
Aripiprazole-Loaded Polymeric Micelles: Fabrication, Optimization and Evaluation using Response Surface Method [0.03%]
利培酮聚合物胶束的制备、优化及响应面法评价研究
Payal H Patil,Pooja R Wankhede,Hitendra S Mahajan et al.
Payal H Patil et al.
Aims and background: The fundamental objective of current study was to encapsulate Aripiprazole (ARP) within Pluronic F127 micelles to improve its aqueous solubility. The recent patents on Aripiprazole (JP2013136621) and ...
A New Approach to Enhance the Solubility of Famotidine Tablet by Using Naturally Isolated Pear Starch [0.03%]
一种新方法：利用天然梨淀粉提高法莫替丁片溶解度
Kushwaha Anjali,Singh P Manjul
Kushwaha Anjali
Purpose: The solubility of drug is affected by various excipients present in formulation. In case of tablet formulation, the role of binders is very important for solubility of dosage form as well as drug. In this study, ...
Chronopharmacokinetic Evaluation of Budesonide Multiparticulate Systems [0.03%]
布地奈德多单元制备系统的 chronopharmakinetische 评估
Sowjanya Battu,Prasanna R Yalavarthi,Venkata S R Gopireddy et al.
Sowjanya Battu et al.
Background: Poor oral absorption of budesonide limits the design of its solid oral dosage form. With this context, multiparticulate pulsatile system of budesonide for chronotherapy of nocturnal asthma was aimed in this st...
Natural Product Formulations for the Prevention and Treatment of Alzheimer's disease: A Patent Review [0.03%]
阿茨海默病的预防和治疗的天然药物组合物专利点评综述
Rumiana Koynova,Boris Tenchov
Rumiana Koynova
Introduction: Although considerable efforts have been made to develop effective therapeutic agents for Alzheimer's Disease (AD), neither a consensus concerning the pathogenesis of the disease nor a successful therapy for ...
Thymoquinone a Potential Therapeutic Molecule from the Plant Nigella sativa: Role of Colloidal Carriers in its Effective Delivery [0.03%]
化橘核中的潜在治疗分子四氢呋喃喹喔啉：胶态载体在其有效递送中的作用
Poonam Negi,Charul Rathore,Gajanand Sharma et al.
Poonam Negi et al.
Background: From the past few decades, remarkable awareness has laid on the use of herbal medicines in pharmaceutical research. Thymoquinone (TQ), the main chemical constituent of Nigella Sativa (NS) plant, has been exten...
Furosemide - Soluplus® Solid Dispersion: Development and Characterization [0.03%]
呋塞米-Soluplus固态分散体的开发与表征研究
Rammani Prasad,Praveen Radhakrishnan,Sandeep K Singh et al.
Rammani Prasad et al.
Background: Recent patents reveal that Soluplus® has proved to be a promising excipient that modulates dissolution characteristics of many active pharmaceutical ingredients (WO2016161995A1, WO2016169534A1 and WO201616567...
Enhanced Both in vitro and in vivo Kinetics by SLNs Induced Transdermal System of Furosemide: A Novel Approach [0.03%]
一种新型的速尿酮的透皮给药系统：载有速尿酮的固体质子交换纳米粒的研究（体内外）
Revathi Mannam,Indira M Yallamalli
Revathi Mannam
Background: Furosemide is a potent diuretic agent used to treat pulmonary arterial hypertension. Variable dosage regimen and poor pharmacokinetic parameters have led to the development of transdermal drug delivery system....