Self-emulsifying Pellets Prepared by Extrusion/Spheronization: In vitro/In vivo Evaluation [0.03%]
一种通过挤出圆整法制备的自乳化颗粒的体内外评价研究
Mohammad A Rahman,Mohammad Mujahid,Arshad Hussain
Mohammad A Rahman
Aims: The purpose of the current study was to investigate the feasibility of producing solid self-emulsifying pellets using the extrusion/spheronization technique with an aim to increase the bioavailability of selected dr...
Liposomal Drug Delivery System for Cancer Therapy: Advancement and Patents [0.03%]
癌症治疗的脂质体药物递送系统进展及专利分析
Sheetal Jha,Pramod K Sharma,Rishabha Malviya
Sheetal Jha
Background: In this review article, authors reviewed about the liposomes which are amongst various drug delivering systems for the delivery of the therapeutic agents at the target site. ...
Formulation Development and Optimization of Matrix Tablet of Tramadol Hydrochloride [0.03%]
盐酸 tramal 脱羧产物及其对映体的生成机制研究
Pulak Deb,Jubaraj Singha,Indranil Chanda et al.
Pulak Deb et al.
Background: The aim of the present investigation is to formulate and optimize oral sustained release matrix tablet of highly water soluble drug Tramadol HCl and to evaluate the effect of varying concentration of hydrophil...
Development and Optimization of Controlled Porosity Osmotic Tablets of Lamotrigine Solid Dispersion [0.03%]
拉莫三嗪固态分散体控制孔渗透片的开发与优化
Gayatri C Patel,Megha Kasarwala
Gayatri C Patel
Background: The purpose of this study was to investigate the application of a controlled porosity osmotic tablet (CPOT) utilizing solid dispersion (SD) of poorly soluble drug. The patents on Cyclobenzaprine HCl (US4968507...
Impact of Pluronic F-68 vs Tween 80 on Fabrication and Evaluation of Acyclovir SLNs for Skin Delivery [0.03%]
Pluronic F-68与Tween 80对阿昔洛韦SLN的制备及皮肤给药评价的影响比较研究
Kaur Bhupinder,Maria J Newton
Kaur Bhupinder
Introduction: The solid lipid nanoparticles (SLNs) of Acyclovir (ACV) were fabricated with Soya lecithin and Fractionated Coconut oil (medium chain glyceride) as a first time combination. ...
Ryan F Donnelly
Ryan F Donnelly
Quality by Design (QbD) Approach for Development of Co-Processed Excipient Pellets (MOMLETS) By Extrusion-Spheronization Technique [0.03%]
基于质量的设计（QbD）开发共处理辅料微丸（MOMLETs）的挤出- spheronization技术zych
Hetal Patel,Kishan Patel,Sanjay Tiwari et al.
Hetal Patel et al.
Background: Microcrystalline cellulose (MCC) is an excellent excipient for the production of pellets by extrusion spheronization. However, it causes slow release rate of poorly water soluble drugs from pellets. Co-process...
Hot Melt Extruded and Injection Moulded Dosage Forms: Recent Research and Patents [0.03%]
热熔挤出和注射成型剂型：近期研究与专利动态
Ian Major,Christopher McConville
Ian Major
Hot Melt Extrusion (HME) and Injection Moulding (IM) are becoming more prevalent in the drug delivery field due to their continuous nature and advantages over current pharmaceutical manufacturing techniques. Hot melt extrusion (HME) is a pr...
Pharmacological Effect of Berberine Chloride in Propyl Thiouracil Induced Thyroidal Dysfunction - A Time Bound Study in Female Rats [0.03%]
小檗碱氯化物对丙硫氧嘧啶所致实验性甲状腺功能低下大鼠的药理作用：雌性 rats的时间限制研究
Harikesh Maurya,Sheena Dhiman,Kamal Dua et al.
Harikesh Maurya et al.
Background: The present study is aimed at bringing out the information on the effect of berberine chloride in hyper and hypo thyroidal model with two dose levels. ...
Nanosized Drug Delivery Systems for Direct Nose to Brain Targeting: A Review [0.03%]
鼻黏膜给药纳米载体递送系统直接脑部定位效应及其机制研究进展
Kunjan Phukan,Marika Nandy,Rupanjali B Sharma et al.
Kunjan Phukan et al.
Background: Drug targeting to brain has always been problematic due to Blood-Brain Barrier (BBB), which, does not allow most of the drugs to pass through it as they are hydrophilic and macromolecular drugs. So, in order t...