Modulation of host cell nucleocytoplasmic trafficking during picornavirus infection [0.03%]
皮克病毒（Picorna）感染期间对宿主细胞核胞质转运的调节作用
Parisa Younessi,David A Jans,Reena Ghildyal
Parisa Younessi
Picornavirus infection is characterised by host cell shutoff, wherein host transcription and translation processes are severely impaired. Picornavirus proteins interact with host cell proteins, resulting in alterations in the host cell synt...
Subcellular trafficking in rhabdovirus infection and immune evasion: a novel target for therapeutics [0.03%]
瑞特病毒的亚细胞转运和免疫逃逸：潜在的新药理学靶点
Sibil Oksayan,Naoto Ito,Greg Moseley et al.
Sibil Oksayan et al.
Vesicular stomatitis virus (VSV) and Rabies Virus (RABV) are the prototypic members of the rhabdovirus family. These viruses have a particularly broad host range, and despite the availability of vaccines, RABV still causes more than 50,000 ...
Viral product trafficking to mitochondria, mechanisms and roles in pathogenesis [0.03%]
病毒感染产品的线粒体运输、机制及其在发病机理中的作用
Chad D Williamson,Roberta L DeBiasi,Anamaris M Colberg-Poley
Chad D Williamson
A wide variety of viruses cause significant morbidity and mortality in humans. However, targeted antiviral therapies have been developed for only a subset of these viruses, with the majority of currently licensed antiviral drugs targeting v...
Peter N Monk,Lynda J Partridge
Peter N Monk
The tetraspanins constitute a conserved superfamily of four-span membrane proteins that are widely distributed in multi-cellular organisms. A characteristic property of tetraspanins is their ability to form lateral associations with one ano...
Editorial: subcellular trafficking of pathogens: targeting for therapeutics [0.03%]
述评：病原体的亚细胞转运：药物研发的新靶点
Gregory W Moseley,David A Jans
Gregory W Moseley
Editorial: cytomegalovirus infection in the fetus, infant, child, and adolescent: an overview of virus genetics and pathogenesis, disease burden, prevention, diagnosis, treatment, antiviral resistance, and drug targets [0.03%]
述评：胎儿、婴儿、儿童和青少年巨细胞病毒感染：病毒遗传学及发病机制、疾病负担、预防、诊断、治疗、抗病毒耐药性及药物靶点概览
Robert W Tolan
Robert W Tolan
Joseph B Cantey,Pablo J Sanchez
Joseph B Cantey
Congenital infections are those that are acquired transplacentally by the fetus from an infected mother. They constitute a major public health burden, affecting millions of infants and children worldwide. Despite significant advances in med...
Sean P Elliott
Sean P Elliott
Cytomegalovirus (CMV) remains the most common cause of congenitally-acquired infection in the United States and is a leading infectious cause of sensorineural hearing loss, cognitive delay, and permanent neurologic sequelae. Although most c...
Marsha Y Russell,April Palmer,Marian G Michaels
Marsha Y Russell
Disease caused by cytomegalovirus (CMV) infection can clinically manifest in a variety of ways in the immunodeficient host and lead to significant morbidity and mortality. Infections can be primary, occur as a result of reactivation of late...
Congenital cytomegalovirus infection: molecular mechanisms mediating viral pathogenesis [0.03%]
先天性巨细胞病毒感染：病毒致病机制的分子机理
Mark R Schleiss
Mark R Schleiss
Human cytomegalovirus (CMV) is responsible for approximately 40,000 congenital infections in the United States each year. Congenital CMV disease frequently produces serious neurodevelopmental disability, as well as vision impairment and sen...