Milagros Rocha,R Herance,S Rovira et al.
Milagros Rocha et al.
Sepsis and septic shock are the major causes of death in intensive care units. Oxidative damage to mitochondria is involved in the development of organ dysfunction associated with sepsis. This syndrome is caused by an excessive defensive an...
Valerie L Sim
Valerie L Sim
Prion diseases, also known as transmissible spongiform encephalopathies, are invariably fatal neurodegenerative diseases for which there are no efficacious treatments. Thousands of compounds have been screened for anti-prion effect, and yet...
Yoshimasa Takahashi,Taishi Onodera,Kazuo Kobayashi et al.
Yoshimasa Takahashi et al.
Viruses form particulate structures possessing high-density B-cell epitopes and viral RNA/DNA, which are ligands for multiple Toll-like receptors (TLRs). B cells are able to sense these viral antigenic signatures through B-cell antigen rece...
David W Scott,Ai-Hong Zhang,Yan Su
David W Scott
The essence of the adaptive immune system is self tolerance, which is maintained by various central and peripheral check points. However, the tolerance mechanisms can be broken in autoimmune disease conditions due to genetic predisposition ...
Functional interactions between B lymphocytes and the innate immune system [0.03%]
B淋巴细胞与固有免疫系统之间的功能相互作用
Vicky Lampropoulou,Ping Shen,Ellen Hilgenberg et al.
Vicky Lampropoulou et al.
The immune system is composed of multiple cell types, which together improve the resistance of the organism against infections. The unfolding of a successful host response ensuring effective protection against pathogens requires an appropri...
Reprogramming of B cells into regulatory cells with engineered fusokines [0.03%]
利用工程化融合素将B细胞重编为调节性细胞
Jiusheng Deng,Jacques Galipeau
Jiusheng Deng
B cells play a pivotal role in host adaptive immunity against pathogenic microorganisms, but may also maladaptively contribute to the pathogenesis of autoimmune diseases. In contrast, distinct B cell subsets have the capacity to regulate ho...
Takeshi Tsubata
Takeshi Tsubata
B lymphocytes (B cells) express a variety of membrane molecules containing immunoreceptor tyrosine-based inhibition motifs (ITIMs) in the cytoplasmic region such as FcγRIIB, FCRLs, CD22, mouse Siglec-G/human Siglec-10, PECAM-1, mouse PIR-B...
Evolutionary and functional relationships of B cells from fish and mammals: insights into their novel roles in phagocytosis and presentation of particulate antigen [0.03%]
鱼类和哺乳动物B细胞的进化及功能关系：吞噬作用以及颗粒状抗原呈递的新角色的启示
J Oriol Sunyer
J Oriol Sunyer
The evolutionary origins of Ig-producing B cells appear to be linked to the emergence of fish in this planet. There are three major classes of living fish species, which from most primitive to modern they are referred to as agnathan (e.g., ...
Unraveling effector functions of B cells during infection: the hidden world beyond antibody production [0.03%]
揭示感染过程中B细胞的效应功能：超越抗体产生之外的隐藏世界
Beatriz León,André Ballesteros-Tato,Ravi S Misra et al.
Beatriz León et al.
Antibodies made by B cells are critically important for immune protection to a variety of infectious agents. However, it is becoming increasingly clear that B cells do more than make antibodies and that B cells can both enhance and suppress...
Tom A Barr,Mohini Gray,David Gray
Tom A Barr
B cells are once again gaining prominence as important programmers of CD4 T cell responses. With widespread use of B cell depletion therapy in the clinic, proving effective in treating diseases previously considered T cell-mediated, the tim...